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Öğe The Changes Associated with Fasting and Acute Heat Stress on Body Temperature Blood Acid-Base Balance and Some Parameters of Japanese Quail(INDIAN VETERINARY ASSOC, 1998) Durgun, Z; Keskin, E[Abstract not Available]Öğe Concentrations of sulfadoxine and trimethoprim in plasma, lymph fluids and some tissues 24 H after intramuscular administration to angora goats(TAYLOR & FRANCIS LTD, 1998) Tras, B; Elmas, M; Yazar, E; Bas, AL; Keskin, E; Dasci, ZThis study was carried out to determine the concentrations of sulfadoxine and trimethoprim in plasma, lymph, and some tissues in goats after administration of a single recommended therapeutic dose. Five healthy, adult Angora goats were used. The drug combination, containing 200 mg sulfadoxine and 40 mg trimethoprim per millilitre, was given as a single IM injection at the recommended dose level, 15 mg/kg body weight for sulfadoxine and 3 mg/kg body weight for trimethoprim. The goats were slaughtered 24 hours after drug administration and samples were taken from liver, bone marrow, pelvic limb muscles, hepatic, thoracic duct, and the pelvic limb lymph fluids for analysis of drug concentrations by HPLC. The concentrations of trimethoprim in bone marrow, liver, pelvic limb muscles, hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were found to be 6, 5, 4, 2, 5 and 15 times higher than those of plasma, respectively. Although the sulfadoxine concentrations in bone marrow, pelvic limb muscles, and liver were 2, 3 and 2 times higher than the plasm concentrations, respectively, the sulfadoxine concentrations in hepatic lymph, the pelvic limb lymph, and thoracic duct lymph were lower than those of plasma. The results show that the trimethoprim concentrations in lymph fluids were quite similar to those in tissues. However, the sulfadoxine concentrations in lymph fluids were different in each tissue.Öğe Effect of garlic oil on erythrocyte membrane phospholipid fractions in hypercholesterolaemic dogs(LIPPINCOTT WILLIAMS & WILKINS, 1997) Keskin, E; Durgun, Z; Kocabatmaz, M; Tras, B; Eryavuz, A; Donmez, NWe studied the effects of a cholesterol diet alone and of a cholesterol diet plus garlic oil on erythrocyte membrane phospholipid fractions in 10 adult mongrel dogs. The animals were fed the control diet plus 0.5% cholesterol for 6 weeks and the control diet containing 5% cholesterol plus garlic oil at 20 mg kg(-1) body weight daily for the last 3 weeks of the experiment. Feeding with the cholesterol-rich diet resulted in significant (p < 0.05) increases in erythrocyte membrane lipids. The administration of garlic oil not only prevented the increases but also reduced the levels of phospholipid and cholesterol, though not significantly. Although phospholipid (PL) fractions showed fluctuations with the cholesterol feeding and garlic oil administration, there was no significant difference between the sampling times. In conclusion, further studies are necessary on the effect of garlic on the membrane PL fractions because of the importance of PL in all aspects of membrane physiology from anion transport to regulation of cell structure.Öğe Effect of garlic oil on plasma, erythrocyte and erythrocyte membrane total lipids, cholesterol and phospholipid levels of hypercholesterolaemic dogs(LIPPINCOTT WILLIAMS & WILKINS, 1997) Kocabatmaz, M; Keskin, E; Durgun, Z; Eryavuz, A30 Adult mongrel dogs were assigned randomly to three groups with 10 animals each. Group 1 served as normal controls and were fed a standard control diet for 9 weeks. Group 2 animals received the control diet plus 0.5% cholesterol powder for 9 weeks and Group 3 animals were fed the control diet plus 0.5% cholesterol for 6 weeks and received the control diet containing 5% cholesterol plus garlic oil at the rate of 20 mg kg(-1) body weight daily for the last 3 weeks of the experiment. The cholesterol-rich diet significantly increased plasma total lipid, total cholesterol and phospholipid levels in Groups 2 and 3 as compared with normally fed dogs' pre-experiment values of Groups 2 and 3 (p < 0.05). Also, erythrocyte and erythrocyte membrane total lipid, cholesterol and phospholipid levels were significantly elevated by the cholesterol-rich diet in Groups 2 and 3 animals (p < 0.05). After 3 weeks of garlic oil administration in Group 3, plasma, erythrocyte and erythrocyte membrane total lipid, total cholesterol and phospholipid levels significantly decreased (p < 0.05) as compared to those in animals receiving cholesterol diet alone. However, their levels were still higher than in this group before the experiment and than those in control dogs. A comparison between Groups 2 and 3 shows that garlic oil had a reducing effect on plasma and erythrocytes and their membrane lipids, and prevents the alimentary hyperlipidaemia.Öğe Effect of pentoxifylline on antioxidant status of healthy and endotoxemic New Zealand white rabbits(VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO, 2005) Keskin, E; Oztekin, E; Col, R; Sivrikaya, A; Uney, K; Yazar, EIn this study, effect of pentoxifylline on antioxidant status of healthy and endotoxemic rabbits was investigated. Endotoxemia was induced with E. coli lipopolysaccharide in New Zealand white rabbits. Forty rabbits were randomly divided into four equal groups. Group 1 served as control. Animals in Group 2 were given lipopolysaccharide (400 mu g/kg) intravenously, in Group 3 pentoxifylline (50 mg/kg) was injected intraperitoneally. In Group 4; pentoxifylline (50 mg/kg intraperitoneally) and lipopolysaccharide (400 mu g/kg, intravenously) were injected simultaneously. Animals were killed, and liver, heart and kidney samples were taken at 6 hours after administrations. Malondialdehyde, superoxide dismutase, glutathione peroxidase and reduced glutathione levels of heart, liver and kidney tissues were measured. Lipopolysaccharide caused significant increases (p < 0.05) in hepatic malondialdehyde, and cardiac, hepatic and renal glutathione peroxidase activities. It however, caused significant (P < 0.05) decrease in hepatic superoxide dismutase activity when compared to control group. Pentoxifylline caused significant (p < 0.05) increases of cardiac and hepatic malondialdehyde levels, cardiac superoxide dismutase and renal glutathione peroxidase activities, and cardiac, hepatic and renal reduced glutathione levels when compared to control group. As a result, pentoxifylline has no exactly beneficial effect on the antioxidant status of healthy and endotoxaemic New Zealand white rabbits at the administered dose and route. Although it was stated that pentoxifylline may be beneficial in endotoxaemia, its antioxidant effect may be dependent on dose, administration route and animal species. For this reason, when pentoxifylline is used in endotoxaemia, a treatment protocol should be done for each animal species.Öğe Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits(AKADEMIAI KIADO, 2005) Col, R; Keskin, E; Atalay, BPentoxifylline (PTX, a methylxanthine derivative) has been found to interrupt early gene activation for tumour necrosis factor, interleukin-1, interleukin-6 and tissue factor production and to improve survival from experimental sepsis. During endotoxaemia, lipopolysaccharide (LPS, endotoxin) and proinflammatory cytokines trigger the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation. The present study was undertaken to determine whether pentoxifylline could prevent coagulation disturbances in LPS-treated rabbits. Endotoxaemia was induced with E. coli lipopolysaccharide in New Zealand White rabbits. Forty rabbits were used and divided into four equal groups. Group I served as a control group; Group 2: lipopolysaccharide was injected intravenously, Group 3: pentoxifylline was injected intraperitoneally, Group 4: lipopolysaccharide and pentoxifylline were injected simultaneously. Blood samples were collected 6 h after the treatments. In rabbits with endotoxin-induced DIC, platelet count, leukocyte count, percentage of differential leukocyte values, fibrinogen level, antithrombin III (AT-III) and protein C (PC) activity were decreased. Moreover, activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged when compared to the control group. In conclusion, haemostatic disturbances associated with endotoxin-induced DIC were moderately suppressed by the administration of PTX.Öğe Effect of sorted anions on the acid-base balance and growing in Japanese quails(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY, 1997) Durgun, Z; Keskin, E; Kocabatmaz, M; Kececi, TIn the study, sixty, 3 weeks old Japanese quail chicks were used and divided equally to four groups. The control groups (I) were fed basal diet and group II, III, IV were fed diet containing 120 meq/kg NaHCO3, CaSO4 and CaHPO4 respectively. Blood samples were taken far measurement of pH, pCO(2), HCO3- and certain electrolytes levels at 0.th, 5.th. and 10.th. days and all chicks were weighed and feed intake was calculated at 0.th and 10. th. days of experimental period. Bicarbonate evidently increased blood pH, pCO(2), HCO3- and plasma Na Values and decreased plasma K values whereas sulfate consistently depressed blood pH, pCO(2), HCO3- and increased plasma K and Ca levels. CaHPO4 did not affect acid-base balance as much as CaSO4. In the study, the highest feed intake and the lowest weight gain were determined in control group although there were no striking differences among the other groups in respect of weight gain and feed intake.Öğe Selected haematological and biochemical values in ostrich chicks and growers(EUGEN ULMER GMBH CO, 2005) Durgun, Z; Keskin, E; Col, R; Atalay, BIn this study, some haematological and biochemical parameters were determined in healthy ostriches (Struthio camelus) of different ages. For this purpose 15 chicks and 13 growers obtained from a commercial hatchery in Konya environment were used. In blood samples, red blood cell counts, haemoglobin amount, haematocrit value, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, red blood cell size (mean corpuscular diameter), thrombocyte counts, white blood cell counts and percentage of leukocyte types were determined. Additionally, cholesterol, triacylglycerol, creatinine, creatinine kinase, glucose, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, total protein and albumin levels were measured in plasma samples. Although the red blood cell counts, haematocrit values, glucose levels and lymphocyte percentage of the chicks were lower than for growers, the heterophil percentage, total protein, cholesterol, triacylglycerol and creatinine kinase were higher than in growers. There was no significant difference in the other parameters investigated between chicks and growers. Based on the results, it was concluded that selected haematological and biochemical values were influenced by the age differences of the ostriches and the data obtained in the study could be useful to establish some baseline values for haematological and biochemical parameters in different ages of the ostriches.
