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Öğe The association between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in the early phase of acute myocardial infarction(OXFORD UNIV PRESS, 2006) Ulgen, M. S.; Ozturk, O.; Yazici, M.; Kayrak, M.; Soylu, A.; Duzenli, M.; Koc, F.[Abstract not Available]Öğe Does estimated glomerular filtration rate affect left ventricular function after ST elevation myocardial infarction?(OXFORD UNIV PRESS, 2013) Vatankulu, M. A.; Bacaksiz, A.; Sonmez, O.; Koc, F.; Ayhan, S.; Demir, K.; Yazici, H. U.[Abstract not Available]Öğe The influence of homocysteine levels on endothelial function and their relation with microvascular complications in T2DM patients without macrovascular disease(SPRINGER-VERLAG ITALIA SRL, 2007) Karabag, T.; Kaya, A.; Temizhan, A.; Koc, F.; Yavuz, S.; Cam, S.The aim of this study was to investigate the influence of homocysteine (hcy) levels on endothelial function by the method of brachial artery ultrasonography and their relation with microvascular complications in type 2 diabetes mellitus (T2DM) patients without macrovascular disease. Fifty-nine T2DM patients with a mean age of 53.4 +/- 8.6 years and diabetes duration of 8.1 +/- 6.2 years and 16 healthy controls with a mean age of 47 +/- 14.5 years were included in the study. Endothelial-dependent and endothelium-independent flow-mediated dilatation (FMD) were evaluated via brachial artery ultrasonography. Fasting plasma glucose (FPG), glycosylated haemoglobin (A1c), lipid profile, hey, B12 and folic acid levels were measured. Diabetic patients and control group individuals were compared with regard to the laboratory values and brachial artery vascular reactivity. Factors influencing endothelium-dependent FMD were investigated with linear regression analysis. Age, gender, body mass index, lipid profiles and hey levels were similar in both groups (p > 0.05). Endothelium-dependent FMD percentages were significantly lower in diabetics than in the control group (7.7 +/- 5.9 vs. 11.7 +/- 7.1%, p < 0.05). Endothelial-independent FMD percentage was similar for both groups (p > 0.05). The upper limit of the reference hcy value was found to be 12.6 mu mol/l in the control group. In the diabetic group, hcy levels were high in 33 patients and normal in 26 patients. No difference was detected between the patients with high hcy levels and those with a normal level with regard to endothelium-dependent and endothelium-independent FMD values (p > 0.05). Mean hcy levels were 16 +/- 1.7 and 13.3 +/- 4.3 mu mol/l in T2DM patients with microvascular complication and those with no microvascular complication, respectively (p < 0.05). Regression analysis revealed that the main factors influencing the endothelial-dependent FMD were FPG, total cholesterol (TC), triglycerides (TG) and high-density lipoprotein (HDL-C) levels (p < 0.05, p=0.05, p=0.05, p=0.02, respectively). Hcy, folic acid and B 12 values did not influence endothelium-dependent FMD (p > 0.05). Diabetes duration and Ale levels were close to being significant although they did not reach statistical significance (p=0.07 and p=0.08 respectively). Hey levels have no effect on endothelium-dependent and endothelium-independent FMD in T2DM patients without macrovascular complications. The influence of classical atherogenic factors (such as FPG, TC, TG and HDL-C levels) on endothelium functions, detected with endothelium-dependent FMD, is greater.Öğe Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations(ELSEVIER SCIENCE BV, 2009) Koc, F.; Uney, K.; Atamanalp, M.; Tumer, I.; Kaban, G.In this study, the pharmacokinetic profile of enrofloxacin (EF) and its major metabolite, ciprofloxacin (CF), were investigated in brown trout (Salmo trutta fario) (n = 150) after intravenous (i.v.) and oral (p.o.) administrations of a single dose of 10 mg kg(-1) body weight (b.w.) at 10 degrees C. The plasma concentrations of the drugs were determined by high-performance liquid chromatography (HPLC-UV) from 0.08 to 120 h. Pharmacokinetic parameters were described by the two-compartment open model for intravenous and oral administrations, respectively. After intravenous administration, the elimination half-life (t(1/2 beta)), apparent volume of distribution at steady-state (V(ss)) and total body clearance (Cl(tot)) of enrofloxacin were 19.14 +/- 1.51 h, 3.40 +/- 0.18 L kg(-1) and 0.14 +/- 0.01 L kg h(-1), respectively. After oral administration, the maximum plasma concentration (C(max)), time of maximum concentration (t(max)) and bioavailability (F%) were 2.30 +/- 0.08 mu g mL(-1), 8 h and 78 +/- 4%, respectively. Ciprofloxacin was not detected in the present study. The elimination half-life for enrofloxacin following oral administration was longer than values calculated for other animals. After oral administration, the mean plasma concentration was well above the minimum inhibitory concentrations (MICs)-that is, >0.5 mu g mL(-1) at 36 h-for most gram-negative fish pathogens. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in brown trout (S. trutta fario) using oral administration of 10 mg kg(-1) body weight; therefore, it may be effective in the therapy for brown trout diseases. (C) 2009 Elsevier B.V. All rights reserved.Öğe Pharmacokinetics of florfenicol in the plasma of Japanese quail(NEW ZEALAND VETERINARY ASSOC INC, 2009) Koc, F.; Uney, K.; Ozturk, M.; Kadioglu, Y.; Atila, A.AIM: To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica). METHODS: Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration. Concentrations of florfenicol in plasma were determined using high-performance liquid chromatography (HPLC). RESULTS: A naive pooled data analysis approach for the plasma concentration-time profile of florfenicol was found to fit a non-compartmental open model. After I/V administration, the mean residence time (MRT), mean volume of distribution at steady state (V(ss)), and total body clearance of florfenicol were 12.0 (SD 0.37) h, 8.7 (SD 0.22) L/kg, and 1.3 (SD 0.08) L/h/kg, respectively. After I/M injection, the MRT, mean absorption time (MAT), and bioavailability were 12.3 (SD 0.37) h, 0.2 (SD 0.02) h, and 79.1 (SD 1.79)%, respectively. CONCLUSIONS: The time for the concentration of florfenicol to fall below the probable effective concentration of 1 mu g/ml of approximately 10 h is sufficient for the minimum inhibitory concentration needed for many bacterial isolates. Further pharmacodynamic studies in quail are needed to evaluate a suitable dosage regimen.Öğe Thyrotoxic hypokalemic periodic paralysis in a Caucasian population: Not too much, not too low - Three new case reports and meta-analysis of 38 Turkish cases(KARGER, 2007) Cesur, M.; Bayram, F.; Temel, M. Akcil; Ozkaya, M.; Kocer, A.; Ertorer, M. E.; Koc, F.[Abstract not Available]
