Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE BV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the pharmacokinetic profile of enrofloxacin (EF) and its major metabolite, ciprofloxacin (CF), were investigated in brown trout (Salmo trutta fario) (n = 150) after intravenous (i.v.) and oral (p.o.) administrations of a single dose of 10 mg kg(-1) body weight (b.w.) at 10 degrees C. The plasma concentrations of the drugs were determined by high-performance liquid chromatography (HPLC-UV) from 0.08 to 120 h. Pharmacokinetic parameters were described by the two-compartment open model for intravenous and oral administrations, respectively. After intravenous administration, the elimination half-life (t(1/2 beta)), apparent volume of distribution at steady-state (V(ss)) and total body clearance (Cl(tot)) of enrofloxacin were 19.14 +/- 1.51 h, 3.40 +/- 0.18 L kg(-1) and 0.14 +/- 0.01 L kg h(-1), respectively. After oral administration, the maximum plasma concentration (C(max)), time of maximum concentration (t(max)) and bioavailability (F%) were 2.30 +/- 0.08 mu g mL(-1), 8 h and 78 +/- 4%, respectively. Ciprofloxacin was not detected in the present study. The elimination half-life for enrofloxacin following oral administration was longer than values calculated for other animals. After oral administration, the mean plasma concentration was well above the minimum inhibitory concentrations (MICs)-that is, >0.5 mu g mL(-1) at 36 h-for most gram-negative fish pathogens. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in brown trout (S. trutta fario) using oral administration of 10 mg kg(-1) body weight; therefore, it may be effective in the therapy for brown trout diseases. (C) 2009 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Pharmacokinetic, Enrofloxacin, Fish, Plasma, Antibiotic
Kaynak
AQUACULTURE
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
295
Sayı
01.02.2020
