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    Evaluation the early effects of single high dose radioiodine therapy on lacrimal gland function
    (IJRR-IRANIAN JOURNAL RADIATION RES, 2014) Gedik, G. K.; Gedik, S.; Koktekir, B. E.; Kebapcilar, L.; Kara, P. O.
    Background: The therapeutic administration of I-131 for thyroid remnant ablation and for metastases comes up with some adverse effects. This study was conducted to investigate whether single high dose radioiodine therapy affects lacrimal gland functions or not. Materials and Methods: Seventy-eight eyes of 39 patients, who were diagnosed as differentiated thyroid carcinoma, were objectively tested with Schiermer's test and tear film break-uptime test; before and 1 and 6 months after high dose (>= 3700 MBq) I-131 therapy. Results: The median values of pre-treatment Schiermer's test were 10.00 mm and 9.60 mm for right and lefteyes, respectively. At the post-treatment first and sixth months, no significant change was observed in the median values of Schiermer's test in both eyes (p= 0.189 and p= 0.085, respectively, Friedman test). The median values of pre-treatment tear film break-uptime test were 9.15 sn and 9.20 sn for right and lefteyes, respectively. The median values of post-treatment tear film break-uptimes reduced at first and sixth months and the difference between the pre-treatment and post-treatment values were significant in both eyes (p=0.020 and p=0.022 for right and lefteyes, respectively, Friedman test). Conclusion: Impairment of goblet cell function occurs early after administration of single high dose I-131 application. However, reduction in tear secretion from lacrimal gland is not observed.
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    In Vivo Confocal Microscopy of Corneal Endothelium in Patients With Retinitis Pigmentosa
    (Saudi Med J, 2012) Gedik, S.; Gonul, S.; Koktekir, B. E.; Bakbak, B.
    Objectives: To evaluate corneal endothelium in patients with retinitis pigmentosa using confocal microscopy, and compare their results with those of healthy controls. Methods: This comparative study took place between June 2009 and June 2011 in the Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya, Turkey. We evaluated both eyes of 17 patients with retinitis pigmentosa (group 1), and the eyes of 17 age- and gender- matched control subjects (group 2). Corneal endothelium of all participants was evaluated using confocal microscopy (ConfoScan 3, Nidek Co. Ltd, Osaka, Japan). Endothelial cell density, polymegethism, and pleomorphism values were noted. Mann-Whitney U test was used to compare the results of these 2 groups. Results: The values for mean endothelial cell density was 2440 +/- 451 cell/mm(2) (range: 1438-3037 cell/mm(2)), 48.3%+/- 8.3 (range: 35.9-81.3%) for polymegethism, and 40.3%+/- 6.8 (range 24.7-53.8%) for pleomorphism in group 1; while in group 2, these values were 2344 +/- 317 cell/mm(2) (range: 1445-2903 cell/mm(2)) for the mean endothelial cell density, 45.3%+/- 9.2 (range: 26.5-80.2%) for polymegethism, and 42.4%+/- 5.3 (range between 24.8-49.5%) for pleomorphism. No statistically significant difference was found between endothelial cell density (p=0.15), polymegethism (p=0.15), and pleomorphism (p=0.16) values of the 2 groups. Conclusion: The endothelial cell density, polymegethism and pleomorphism values in patients with retinitis pigmentosa do not differ from those of healthy individuals. Since retinitis pigmentosa is a heterogeneous group of diseases, further studies with larger number and more homogeneous groups of patients are needed. Saudi Med J 2012; Vol. 33 (12): 1330-1333