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Öğe A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I(TURKISH LEAGUE AGAINST RHEUMATISM, 2012) Solak, Yalcin; Atalay, Huseyin; Polat, Ilker; Biyik, Zeynep; Gaipov, Abduzhappar; Kucuk, Adem; Turk, SuleymanFamilial Mediterranean fever (FMF) is the prototype of autoinflammatory syndromes. Several factors may trigger the disease including physical and emotional stress, fat-rich diet, and menstruel cycle. Infections and some drugs such as cisplatin may result in a change in cytokine levels and may precipitate attacks. Most cases of FMF presents with typical self-limited attacks including fever and abdominal pain. However, a minority of patients, called as phenotype II, presents with amyloidosis AA-type and/or end-stage renal disease in the absence of clinically recognizable attacks. Immunosupression may precipitate a typical FMF attack, possibly through a change in cytokine balance. Initiation of colchicine treatment in these patients is of utmost importance to prevent amyloidosis involvement of the newly transplanted graft. In this article, we present a rare case of FMF who transformed from phenotype II to phenotype I after renal transplantation, most probably due to the effect of immunosuppressants.Öğe Epicardial Adipose Tissue and Atherosclerosis In Patients With Familial Mediterranean Fever(WILEY-BLACKWELL, 2013) Kucuk, Adem; Solak, Yalcin; Akilli, Hakan; Yildirim, Oguzhan; Guler, Ibrahim; Ucar, Ramazan; Aribas, Alpay[Abstract not Available]Öğe Evaluation of frequency of irritable bowel syndrome in patients with chronic urticaria(2018) Unal, Mehmet; Kucuk, Adem; Akyürek, Fatma Tunçez; Kaya, Zeynep Gizem İslamoğluAim: Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder. Urticaria is a disease with papules and plaques accompanied by pruritus and edema. In this study, the relationship between these two diseases, which have many common features, was evaluated.Material and Methods: Patients with urticaria and volunteers who did not have any dermatologic disease were included in the study. Participants were assessed for diagnosis of IBS according to Rome III diagnostic criteria. In addition, findings supporting IBS diagnosis, and fecal shape and consistency were evaluated.Results: Fifty urticaria patients (18 males - 36% and 32 females - 64%) and 70 volunteers (38 males - 54.3% and 32 females - 45.7%) were evaluated. The mean age of the urticaria group was 34.8 15.0; the mean age of the control group was 25.8 10.9. IBS was detected in 34 (68%) patients in the urticaria group; and in 22 (31.4%) controls (p 0.001). Diagnosis-supporting findings were more frequently detected in the group of urticaria (p values respectively: 0.037; 0.001; 0.036; 0.050). It was observed that the higher the serum IgE level, the higher the incidence of IBS in chronic urticaria patients ( p: 0.02; eta: 0.206).Conclusion: IBS was observed more frequently in urticaria patients. Diagnosis-supporting findings for IBS were found more frequently in urticaria patients. Serum IgE values also seem to be associated with IBS. These results indicate an association between chronic urticaria and IBS. For this reason, the presence of IBS in patients with chronic urticaria diagnosis should be questioned.Öğe EVALUATION OF THE SLEEP QUALITY IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER(CARBONE EDITORE, 2015) Kucuk, Adem; Albayrak, Ilknur; Bagcaci, Sinan; Karpuz, Savas; Kucuksen, Sami; Tunc, RecepBackground: Familial Mediterranean Fever (FMF) is a hereditary autoimmune disorder characterised by acute attacks of fever and serosal inflammation. This study aimed to investigate sleep quality in patients with familial Mediterranean fever (FMF). Methods The study involved 86 patients. The patients were enrolled in the study during an attack-free period. The sleep quality of all the patients. was evaluated by the Pittsburgh Sleep Quality Index (PSQ1). Results: The PSQ1 total score was 6.5 +/- 4 and the prevalence of poor sleepers was 50% (43/86) according the PSQ1 total score in this study. Women with a higher number of attacks per year and patients resistant to the colchicine treatment had a. poorer sleep quality (p<0.05)., Conclusions: This study underlines the need to assess and manage sleep problems in patients with FMF. Poor sleep quality cause other symptoms of the disease to aggravate. So, the physician must also assess the sleep quality when questioning the routine complaints Of the patients with FMF.Öğe Pain, depression levels, fatigue, sleep quality, and quality of life in elderly patients with rheumatoid arthritis(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2017) Albayrak Gezer, Ilknur; Balkarli, Ayse; Can, Beray; Bagcaci, Sinan; Kucuksen, Sami; Kucuk, AdemBackground/aim: The aim of this study was to evaluate and determine the relationships (if any) among pain, depression levels, fatigue, sleep quality, and quality of life in patients with rheumatoid arthritis (RA) aged 65 years and over, and to compare the results with those of RA patients under 65 years of age. Materials and methods: The study included 52 patients with RA aged 65 years and over (Group 1) and 84 patients with RA under 65 years of age (Group 2). Pain, depression levels, fatigue, sleep quality, quality of life, and disease activity of all of the participants were evaluated using a visual analog scale (VAS), the Beck Depression Inventory (BDI), the Checklist Individual Strength (CIS), the Pittsburgh Sleep Quality Index (PSQI), the Short Form-36 (SF-36), and the Disease Activity Score-28, respectively. Results: When the two groups were compared, higher scores for the VAS, BDI, total CIS, and PSQI were found in Group 1 compared to Group 2 (P = 0.003, P = 0.003, P = 0.007, and P = 0.001, respectively). The SF-36 subscales of the physical component summary and mental component summary were not statistically significantly different between the two groups (P > 0.05). Conclusion: This study evaluated the situation in elderly patients with RA and showed that pain, depression level, fatigue, and sleep quality worsen with age.Öğe Sexual dysfunction, mood, anxiety, and personality disorders in female patients with fibromyalgia(DOVE MEDICAL PRESS LTD, 2016) Kayhan, Fatih; Kucuk, Adem; Satan, Yilmaz; Ilgun, Erdem; Arslan, Sevket; Ilik, FaikBackground: We aimed to investigate the current prevalence of sexual dysfunction (SD), mood, anxiety, and personality disorders in female patients with fibromyalgia (FM). Methods: This case-control study involved 96 patients with FM and 94 healthy women. The SD diagnosis was based on a psychiatric interview in accordance with the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Mood and anxiety disorders were diagnosed using the Structured Clinical Interview. Personality disorders were diagnosed according to the Structured Clinical Interview for DSM, Revised Third Edition Personality Disorders. Results: Fifty of the 96 patients (52.1%) suffered from SD. The most common SD was lack of sexual desire (n=36, 37.5%) and arousal disorder (n=10, 10.4%). Of the 96 patients, 45 (46.9%) had a mood or anxiety disorder and 13 (13.5%) had a personality disorder. The most common mood, anxiety, and personality disorders were major depression (26%), generalized anxiety disorder (8.3%), and histrionic personality disorder (10.4%). Conclusion: SD, mood, and anxiety disorders are frequently observed in female patients with FM. Pain plays a greater role in the development of SD in female patients with FM.