A Case of Familial Mediterranean Fever After Renal Transplantation: From Phenotype II to I
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH LEAGUE AGAINST RHEUMATISM
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Familial Mediterranean fever (FMF) is the prototype of autoinflammatory syndromes. Several factors may trigger the disease including physical and emotional stress, fat-rich diet, and menstruel cycle. Infections and some drugs such as cisplatin may result in a change in cytokine levels and may precipitate attacks. Most cases of FMF presents with typical self-limited attacks including fever and abdominal pain. However, a minority of patients, called as phenotype II, presents with amyloidosis AA-type and/or end-stage renal disease in the absence of clinically recognizable attacks. Immunosupression may precipitate a typical FMF attack, possibly through a change in cytokine balance. Initiation of colchicine treatment in these patients is of utmost importance to prevent amyloidosis involvement of the newly transplanted graft. In this article, we present a rare case of FMF who transformed from phenotype II to phenotype I after renal transplantation, most probably due to the effect of immunosuppressants.
Açıklama
Anahtar Kelimeler
Familial Mediterranean Fever, immunosuppression, phenotype I, phenotype II, renal transplantation
Kaynak
TURKISH JOURNAL OF RHEUMATOLOGY
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
27
Sayı
2
