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Öğe Akut Yüzme Egzersizi Yaptırılan Ratlarda Çinko Eksikliği ve Uygulamasının Bazı Hematolojik Parametrelere Etkisi(2002) Baltacı, Abdülkerim Kasım; Özyürek, Kürşat; Moğulkoç, Rasim; Kurtoğlu, Erdal; Öztekin, Esma; Kul, AylinAmaç: Bu çalışma akut yüzme egzersizi yaptırılan ratlarda çinko eksikliğinin ve çinko uygulamasının bazı hematolojik parametreleri nasıl etkilediğinin ortaya konulabilmesi amacıyla gerçekleştirildi. Yöntem: Araştırma çinko eksik yüzme grubu (grup I, n10), çinko takviyeli yüzme grubu (grup II, n10), yüzme kontrol grubu (grup III, n10), genel kontrol grubu (grup IV, n10) olmak üzere toplam 40 adet Spraque-Dawley cinsi erişkin erkek rat üzerinde gerçekleştirildi. Dört hafta süren çalışmanın bitiminde deney hayvanlarından dekapitasyonla alınan kan örneklerinde eritrosit, hemoglobin, hematokrit, lökosit, lenfosit, trombosit parametreleri (otomatik kan sayım cihazı ile) ve plazma çinko düzeyleri (atomik absorpsiyon spektrofotometresi ile) tayin edildi. Bulgular: Grup 1'in eritrosit, Hb, Hct ve lenfosit değerleri en düşük, Grup 2'nin aynı değerleri en yüksekti. Grup 2'nin trombosit sayısı diğer gruplardan düşüktü. Sonuç: Bulgularımız çinko eksikliğinin belirtilen parametreleri olumsuz, çinko uygulamasının ise olumlu olarak etkilediğini düşündürmektedir. Sonuç olarak çinko uygulaması fiziksel performansı artırıcı yönde etki gösterebilir.Öğe Effect of testosterone supplementation on leptin release in rats after castration and/or unilateral surrenalectomy(VIA MEDICA, 2012) Kul, Aylin; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimIntroduction: The objective of this study was to examine the effect of testosterone supplementation on leptin release in rats which underwent castration and unilateral surrenalectomy. Material and methods: The study was conducted on 80 adult male Wistar albino rats. Animals were divided into eight groups, with ten animals in each group. Group 1 was the Control group, Group 2 the Testosterone group, Group 3 the Castration group, Group 4 the Surrenalectomy group, Group 5 the Castration and Surrenalectomy group, Group 6 the Castration and Testosterone group, Group 7 the Surrenalectomy and Testosterone group, and Group 8 the Castration, Surrenalectomy and Testosterone group. The animals in Groups 2, 6, 7 and 8 were administered 5 mg/kg/day intramuscular testosterone propionate for four weeks. Blood samples were collected for analyses of leptin, LH, FSH and free and total testosterone levels in plasma. Results: Groups 3 and 5 had the highest leptin and LH levels of all the groups (p<0.01). Leptin and LH levels in Groups 1 and 4 were higher than those in Groups 2, 6, 7 and 8 (p<0.01). A comparison of groups with regard to plasma FSH levels showed that the concerned parameter was significantly higher in Groups 3 and 5 than in the other groups (p<0.01). FSH levels in Groups 1 and 4 were lower than those in all other group (p<0.01). The highest testosterone levels were obtained in Groups 2, 6, 7 and 8 (p<0.01). Testosterone levels in Groups 1 and 4 were higher than those in Groups 3 and 5 (p<0.01). Conclusions: This study demonstrates that unilateral surrenalectomy in rats does not have a significant effect on leptin release, while plasma LH levels, rather than testosterone, may be more effective on plasma leptin. (Pol J Endocrinol 2012; 63 (2): 119-124)Öğe Effects of Zinc Deficiency and Supplementation on Malondialdehyde and Glutathione Levels in Blood and Tissues of Rats Performing Swimming Exercise(Humana Press Inc, 2003) Öztürk, Ahmet; Baltacı, Abdülkerim Kasım; Moğulkoç, Rasim; Öztekin, Esma; Sivrikaya, Abdullah; Kurtoğlu, Erdal; Kul, AylinThe aim of the study was to investigate the effects of zinc deficiency and supplementation on lipid peroxidation and glutathione levels in blood and in some tissues of rats performing swimming exercise. Forty adult male Sprague-Dawley rats were divided into four groups: group 1, zinc-deficient consisted of swimming rats; group 2 consisted of zinc-supplemented swimming rats; groups 3 and 4 were the swimming and nonswimming controls, respectively. The levels of malondialdehyde and glutathione were measured after 4 wk of zinc-deficient or zinc-supplemented diet and 30 min of swimming exercise daily. The erythrocyte glutathione levels of groups 2 and 4 were significantly higher than those of groups 1 and 3 (p<0.01). The plasma malondialdehyde level of group 1 was significantly higher than all other groups. The glutathione levels in liver, kidney, striated muscle, and testes of group 2 were higher than in the other groups (p<0.01) and higher in kidney and striated muscle of group 3 than in groups 1 and 4 (p<0.01). The tissue malondialdehyde levels of striated muscle, liver, kidney, and testes of group 1 were significantly higher than for all other groups (p<0.01). Our findings suggest that both swimming exercise and zinc deficiency result in an increase of lipid peroxidation in tissues and that zinc supplementation prevents these alterations by the activation of the antioxidant system.Öğe Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats(Marcel Dekker Inc, 2003) Baltacı, Abdülkerim Kasım ; Moğulkoç, Rasim; Bediz, Cem Şeref; Kul, Aylin; Uğur, AyşegülThe present study was conducted to investigate how pinealectomy and zinc deficiency separately or in combination affected thyroid hormones in rats. The study was carried out on 40 Sprague-Dawley male rats. The rats were equally allocated to four groups: Group 1 (control group), Group 2 (zinc-deficient group), Group 3 (pinealectomized group) and Group 4 (pinealectomized and zinc-deficient group). At the end of a 4-week study period, the rats were decapitated and blood samples were taken. The samples were examined in terms of plasma zinc, melatonin, free and total T-3, T-4, and TSH. It was found that free T-3 and T-4 levels in the pinealectomized group (Group 3) were higher than all others (p < 0.01) while free T-3, T-4, and TSH levels in the zinc-deficient group (Group 2) were lower than all others (p < 0.01). Free T3 and T4 levels in the pinealectomized zinc-deficient group (Group 4) were lower than those in Groups I and 3 and higher than those in Group 2 (p < 0.01). The findings obtained at the end of the study period show that pinealectomy has a stimulating and zinc deficiency has a suppressing effect on thyroid hormones and that the suppressing effect caused by zinc deficiency is partially balanced by pinealectomy.
