Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marcel Dekker Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The present study was conducted to investigate how pinealectomy and zinc deficiency separately or in combination affected thyroid hormones in rats. The study was carried out on 40 Sprague-Dawley male rats. The rats were equally allocated to four groups: Group 1 (control group), Group 2 (zinc-deficient group), Group 3 (pinealectomized group) and Group 4 (pinealectomized and zinc-deficient group). At the end of a 4-week study period, the rats were decapitated and blood samples were taken. The samples were examined in terms of plasma zinc, melatonin, free and total T-3, T-4, and TSH. It was found that free T-3 and T-4 levels in the pinealectomized group (Group 3) were higher than all others (p < 0.01) while free T-3, T-4, and TSH levels in the zinc-deficient group (Group 2) were lower than all others (p < 0.01). Free T3 and T4 levels in the pinealectomized zinc-deficient group (Group 4) were lower than those in Groups I and 3 and higher than those in Group 2 (p < 0.01). The findings obtained at the end of the study period show that pinealectomy has a stimulating and zinc deficiency has a suppressing effect on thyroid hormones and that the suppressing effect caused by zinc deficiency is partially balanced by pinealectomy.
Açıklama
Anahtar Kelimeler
Pinealectomy, Zinc Deficiency, Thyroid Hormones, Rat
Kaynak
Endocrine Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
29
Sayı
4
Künye
Baltacı, A. K., Moğulkoç, R., Bediz, C. Ş., Kul, A., Uğur, A., (2003). Pinealectomy and Zinc Deficiency Have Opposite Effects on Thyroid Hormones in Rats. Endocrine Research, 29(4), 473-481. Doi: 10.1081/ERC-120026953
