Yazar "Kurşunlu, Ahmed Nuri" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Assessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytes
    (Academic Press, 2020) Liman, Recep; Kurşunlu, Ahmed Nuri; Ciğerci, İbrahim Hakkı; Özmen, Mustafa; Açıkbaş, Yaser
    In this study pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) which is used for detecting radioactive element, gas adsorption and toxic ions were synthesized. These materials were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), elemental analysis, melting point, Mass Spectroscopy, Scanning Electron Microscopy (SEM) and Zeta Potential. The cytotoxic and genotoxic potential of P5 and P5-6Q at distinct concentrations of 12.5, 25, 50, and 100 ?g/mL were also investigated by Allium ana-telophase and comet assays on Allium cepa roots and Drosophila melanogaster haemocytes. P5 and P5-6Q showed dose dependent cytotoxic effect by decreasing mitotic index (MI) and genotoxic effect by increasing chromosomal aberrations (CAs such as disturbed anaphase-telophase, polyploidy, stickiness, chromosome laggards and bridges) and DNA damage at the exposed concentrations. These changes in P5-6Q were lower than P5. Further research is necessary to clarify the cytotoxic and genotoxic action mechanisms of P5 and P5-6Q at molecular levels.
  • Küçük Resim
    Öğe
    Bazı klorlu Schiff bazlarının sentezi ve immobilizasyon uygulamaları
    (Selçuk Üniversitesi Fen Bilimleri Enstitüsü, 2008) Kurşunlu, Ahmed Nuri; Güler, Ersin
    Bu çalışmanın birinci aşamasında, klor ihtiva eden üç adet Schiff bazı ligandı sentezlendi ve bunların bazı metallerle kompleks oluşturma yetenekleri denendi. Bu Schiff bazı ligandları; (E)-2-[(2-kloroetilimino)metil)fenol , (E)-4-[(2-kloroetilimino)metil)fenol, N,N'-[1,4-fenilendi(E)metiliden]bis(2-kloroetanamin) ligandlarıdır. Çalışmanın ikinci aşamasında ise 180 o C sıcaklıkta aktif hale getirilen silika jelin (3-aminopropil)metoksisilan ile modifikasyonu gerçekleştirildi. Modifiye edilmiş bu silika yapısının fonksiyonel ucuna (NH2 ) çalışmanın birinci aşamasında sentezlenen klor uçlu Schiff bazı ligandları immobilize edildi. Elde edilen Schiff bazı esaslı silika yapıların bazı metalleri tutabilme yetenekleri denendi. Daha sonra bu Schiff bazlarının immobilizasyon öncesi ve sonrası metal tutabilme (metal kompleksi oluşturabilme) yetenekleri karşılaştırıldı. Elde edilen Schiff bazları, metal kompleksleri, aktif silika jel ve modifiye silika jel 1H-NMR, FT-IR, TGA, AAS, elementel analiz, manyetik süsseptibilite teknikleri kullanılarak karakterize edildi.
  • Küçük Resim
    Öğe
    Bor-dipirin'den türeyen yeni liganların metal komplekslerinin sentezi ve lüminesans özelliklerinin incelenmesi
    (Selçuk Üniversitesi Fen Bilimleri Enstitüsü, 2014-03-10) Kurşunlu, Ahmed Nuri; Güler, Ersin
    Bu tez çalışması temel olarak iki aşamada gerçekleştirilmiş olup bileşiklerin sentezi ve onların spektroskopik uygulamalardan oluşmuştur. Ticari veya sentez aldehit bileşikleri ve açil halojenürler pirol veya 2,4-dimetil-3-etil pirol bileşikleri ile uygun şartlarda reaksiyona tabi tutulmuş ve istenilen çıkış-Bodipy grupları elde edilmiştir. Amaca bağlı olarak daha sonraki sentez işlemlerinde iki farklı metot kullanılmıştır. Bunlardan ilki; çıkış-Bodipy bileşiğine kompleks oluşturabilecek uygun organik grupların bağlanmasıdır. Diğeri ise; klasik metotla hazırlanmış olan metal kompleks bileşiklerin yine Bodipy yapısına bağlanmasını içermektedir. Tez çalışmasının ikinci aşamasında gerçekleştirilen spektroskopik çalışmalar yapılan iki farklı sentez metoduna bağlı olarak; birinci metotla hazırlanan fonksiyonel Bodipy gruplarının metal katyon hassasiyeti çözelti ortamında Uv-vis ve florimetrik metotlarla tespit edilmiştir. İkinci metotla hazırlanan kompleks bileşikler ise benzer şekilde Uv-vis ve florimetrik değerlerdeki değişmelerin yorumlanması esasına dayanmaktadır. Spektroskopik uygulamaların sonunda hazırlanan ligandların floresan katyon sensörü veya kemosensör olarak kullanılıp kullanamayacağının değerlendirilmesi yapılmıştır.
  • Küçük Resim
    Öğe
    Haloalkanes and aromatic hydrocarbons sensing using Langmuir-Blodgett thin film of pillar[5]arene-biphenylcarboxylic acid
    (ELSEVIER SCIENCE BV, 2019) Kurşunlu, Ahmed Nuri; Açıkbaş, Yaser; Özmen, Mustafa; Erdoğan, Matem; Çapan, Rıfat
    Here, a pillar [5]arene derivative including biphenylcarboxylic acid groups was designed for obtaining a macrocycle with an ideal cavity for volatile organic compounds. The pillar[5]arene -biphenylcarboxylic acid (P5-BPCA) based Langmuir-Blodgett (LB) thin films were produced onto 50 nm thick gold-coated glass and 3.5 MHz quartz crystal substrates to form a thin film chemical sensor element. Surface plasmon resonance (SPR) and Quartz crystal microbalance (QCM) techniques were employed to characterize all the P5-BPCA LB thin film layers. The mass of LB film layer loaded onto a quartz crystal and the resonance frequency shifts per layer were determined to be 711.71 ng per layer (2.68 ng mm(-2)) and 48.24 Hz per layer, respectively. The P5-BPCA LB thin film sensor element was exposed to various haloalkane and aromatic hydrocarbon vapors. The sensitivities of the P5-BPCA LB film sensor were determined between 1.776 and 3.976 Hz ppm(-1). Sensitivity with detection limits were obtained between 0.754 and 1.689 ppm against organic vapors. The results showed that P5-BPCA LB thin film was highly selective with a large response to chloromethane vapor.
  • Küçük Resim
    Öğe
    Investigation of environmentally volatile pollutants sensing using pillar[5]arene-based macrocycle Langmuir-Blodgett film
    (SPRINGER HEIDELBERG, 2020) Özmen, Mustafa; Kurşunlu, Ahmed Nuri; Açıkbaş, Yaser; Erdoğan, Matem; Çapan, Rıfat
    This study presented that a novel pillar[5]arene-appended salicylaldehyde (P5-S) was structured in a suitable cavity, which plays an important role in macrocyclic host-guest interactions. P5-S thin films were fabricated and characterized via Langmuir-Blodgett (LB), UV-vis spectrophotometer and quartz crystal microbalance (QCM) techniques, respectively. A QCM sensor deposited with an LB thin film of P5-S macrocyclic molecule was used as a sensitive material for the detection of aliphatic chlorinated hydrocarbons and aromatic hydrocarbons such as carbon tetrachloride, chloroform, dichloromethane and benzene, toluene and m-xylene vapors, respectively. These harmful organic vapors are a source of danger to the environment and are a group of important environmental pollutants. Similar tests were performed with surface plasmon resonance (SPR) technique, and SPR kinetic results were obtained in good agreement with QCM kinetic results. Also, the sensitivity and detection performance of the P5-S QCM chemical sensor to six different pollutants were determined.
  • Küçük Resim Yok
    Öğe
    Preparation of pillar[5] arene-quinoline Langmuir-Blodgett thin films for detection of volatile organic compounds with host-guest principles
    (ROYAL SOC CHEMISTRY, 2017) Kurşunlu, Ahmed Nuri; Açıkbaş, Yaser; Özmen, Mustafa; Erdoğan, Matem; Çapan, Rıfat
    In this study, a novel pillar[5] arene-quinoline (P5-Q) as an organic material is used to fabricate LangmuirBlodgett (LB) thin films and its organic vapor sensing properties have been investigated. The LB deposition process is characterized by UV-visible spectroscopy, atomic force microscopy (AFM), scanning electron microscopy (SEM) and quartz crystal microbalance (QCM) techniques. The typical frequency shift per layer is obtained as 31.75 Hz per layer and the deposited mass onto a quartz crystal is calculated to be 539.69 ng per layer (2.03 ng mm(-2)). The fitted surface plasmon resonance (SPR) data were utilized to calculate the film thickness of this material. The thickness of a single layer is calculated to be 1.26 +/- 0.09 nm. QCM and SPR systems are used to investigate gas sensing performance of macrocyclic LB films during exposure to Volatile Organic Compounds (VOCs). The macrocyclic LB thin films are more sensitive to dichloromethane than that of other vapors used in this study. The sensitivity and detection limit performance of the P5-Q QCM sensor to dichloromethane vapor were calculated to be 14.751 Hz ppm(-1) and 0.203 ppm, respectively. These results demonstrated that the P5-Q material is promising as an organic vapor sensing device at room temperature. Despite Langmuir-Blodgett being a traditional technique in colloid and interface science, this study presents the first gas sensor application for pillararene LB films. Because of the unique symmetric pillar architecture of P5-Q, self-assembly of pillar[5] arene molecules should afford various characteristic nanometer-scale architectures such as micelles, vesicles, and tubes.