Assessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytes
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) which is used for detecting radioactive element, gas adsorption and toxic ions were synthesized. These materials were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), elemental analysis, melting point, Mass Spectroscopy, Scanning Electron Microscopy (SEM) and Zeta Potential. The cytotoxic and genotoxic potential of P5 and P5-6Q at distinct concentrations of 12.5, 25, 50, and 100 ?g/mL were also investigated by Allium ana-telophase and comet assays on Allium cepa roots and Drosophila melanogaster haemocytes. P5 and P5-6Q showed dose dependent cytotoxic effect by decreasing mitotic index (MI) and genotoxic effect by increasing chromosomal aberrations (CAs such as disturbed anaphase-telophase, polyploidy, stickiness, chromosome laggards and bridges) and DNA damage at the exposed concentrations. These changes in P5-6Q were lower than P5. Further research is necessary to clarify the cytotoxic and genotoxic action mechanisms of P5 and P5-6Q at molecular levels.
Açıklama
Anahtar Kelimeler
Allium cepa, Comet, DNA damage, Drosophila melanogaster, Pillar[5]arene
Kaynak
Ecotoxicology and Environmental Safety
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
192
Sayı
Künye
Liman, R., Kurşunlu, A. N., Ciğerci, İ. H., Özmen, M., Açıkbaş, Y. (2020). Assessment Of The Cytotoxic And Genotoxic Potential Of Pillar[5]Arene Derivatives By Allium Cepa Roots And Drosophila Melanogaster Haemocytes. Ecotoxicology and Environmental Safety, 192.
