Assessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytes

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dc.contributor.authorLiman, Recep
dc.contributor.authorKurşunlu, Ahmed Nuri
dc.contributor.authorCiğerci, İbrahim Hakkı
dc.contributor.authorÖzmen, Mustafa
dc.contributor.authorAçıkbaş, Yaser
dc.date.accessioned2020-03-26T20:20:37Z
dc.date.available2020-03-26T20:20:37Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn this study pillar[5]arene (P5) and a quinoline-functionalized pillar[5]arene (P5-6Q) which is used for detecting radioactive element, gas adsorption and toxic ions were synthesized. These materials were characterized by Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), elemental analysis, melting point, Mass Spectroscopy, Scanning Electron Microscopy (SEM) and Zeta Potential. The cytotoxic and genotoxic potential of P5 and P5-6Q at distinct concentrations of 12.5, 25, 50, and 100 ?g/mL were also investigated by Allium ana-telophase and comet assays on Allium cepa roots and Drosophila melanogaster haemocytes. P5 and P5-6Q showed dose dependent cytotoxic effect by decreasing mitotic index (MI) and genotoxic effect by increasing chromosomal aberrations (CAs such as disturbed anaphase-telophase, polyploidy, stickiness, chromosome laggards and bridges) and DNA damage at the exposed concentrations. These changes in P5-6Q were lower than P5. Further research is necessary to clarify the cytotoxic and genotoxic action mechanisms of P5 and P5-6Q at molecular levels.en_US
dc.description.sponsorshipBAP-192019en_US
dc.description.sponsorshipWe are thankful to Research Foundation of Selcuk University ( BAP-192019 ) for partially supporting. The authors express their appreciation to Prof. J.-F. Nierengarten and Dr. I. Nierengarten for helpful discussions.en_US
dc.identifier.citationLiman, R., Kurşunlu, A. N., Ciğerci, İ. H., Özmen, M., Açıkbaş, Y. (2020). Assessment Of The Cytotoxic And Genotoxic Potential Of Pillar[5]Arene Derivatives By Allium Cepa Roots And Drosophila Melanogaster Haemocytes. Ecotoxicology and Environmental Safety, 192.
dc.identifier.doi10.1016/j.ecoenv.2020.110328en_US
dc.identifier.issn0147-6513en_US
dc.identifier.pmid32078840en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ecoenv.2020.110328
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38629
dc.identifier.volume192en_US
dc.identifier.wosWOS:000518502300028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurşunlu, Ahmed Nuri
dc.institutionauthorÖzmen, Mustafa
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAllium cepaen_US
dc.subjectCometen_US
dc.subjectDNA damageen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectPillar[5]areneen_US
dc.titleAssessment of the cytotoxic and genotoxic potential of pillar[5]arene derivatives by Allium cepa roots and Drosophila melanogaster haemocytesen_US
dc.typeArticleen_US

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