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Öğe O-alkylation of pyridine aldo- and ketoximes with dihalohydrins under phase-transfer conditions(TAYLOR & FRANCIS INC, 2007) Kocak, Abmet; Kurbanli, Sultan; Malkondu, SaitPhase-transfer-catalyzed alkylation of (E)-pyridine aldo- and (E)-ketoximes with dihalohydrins in the benzene (or DMSO)/10% aq. NaOH system in the presence of tetradecylammonium bromide proceeds regiospecifically to afford the corresponding O-halohydrins in good yields. In this study, first O-halohydrin derivatives were converted into glycidyl ether derivatives, and then a new series of amino alcohols were synthesized by the condensation of amines with these glycidyl ethers.Öğe Synthetic Access to New Carbamate and Thiocarbamate Derivatives from Pyridinecarbaldehyde Oximes and Hydroxypyridines(TAYLOR & FRANCIS INC, 2011) Kocak, Ahmet; Ahmetli, Gulnare; Kocak, Nuriye; Malkondu, Sait; Yaylaci, Aysegul; Kurbanli, Sultan[image omitted] The synthesis of pyridine carbamate and thiocarbamate derivates is described. A series of oxime carbamate and thiocarbamate derivatives were synthesized by the addition of 2-, 3-, and 4-pyridinecarbaldehyde oximes to isocyanates and isothiocyanates. Furthermore, carbamate and thiocarbamate derivatives of pyridine were synthesized by the addition of 2-, 3-, and 4-hydroxy pyridine to isocyanates and isothiocyanates. Their structures were confirmed by both analytical and spectral data.Öğe Synthetic access to new pyridone derivatives through the alkylation reactions of hydroxypyridines with Epoxides(TAYLOR & FRANCIS INC, 2007) Kocak, Ahmet; Kurbanli, Sultan; Malkondu, SaitGeneral methods for the preparation of a variety of pyridone and oxypyridine derivatives are described. 2-,3-,4-Hydroxy pyridine and 2-pyridinemethanol were alkylated with ethylene-, propylene-, and stryrene-oxide and epichlorohydrin in the presence of different Lewis acids as a catalyst. The best yield of 3a was achieved in the presence of CdI2/BF3 -OEt2. The corresponding pyridone derivatives (3a-d, 7a-d) were obtained from the reaction of 2- and 4-hydroxypyridine with oxiranes in good yields, whereas oxypyridine derivatives (5a-d, 9a,b) were obtained from reactions of 3-hydroxypyridine and 2-pyridinemethanol with oxiranes. Chlorohydrines (3d, 5d, 7d) were easily converted to corresponding epoxy derivatives (10, 11, 12) in basic medium; then amino alcohols (13-17) were obtained from the reaction of these epoxy derivatives with amines.