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Öğe The effect of cognitive functions on the ability to learn how to use a Diskus device in patients with chronic obstructive pulmonary disease(TURKISH RESPIRATORY SOC, 2018) Tulek, Baykal; Atalay, Nart Bedin; Kurtipek, Ercan; Yildirim, Gulfem; Kanat, Fikret; Suerdem, MecitOBJECTIVE: Dry powder inhalers are a group of inhaled medications commonly used for the treatment of chronic obstructive pulmonary disease (COPD). Although they can be more easily administered than metered dose inhalers, there is a high rate of errors in device use. The present study aims to evaluate the relationship between the ability to learn how to use a Diskus device and cognitive functions in patients with COPD. MATERIALS AND METHODS: The study included 30 inhaler-naive patients who were newly diagnosed with COPD. During their first visit, patients were administered a broad array of standardized neuropsychological tests and given a training on inhaler use. During the second visit, patients were divided into two groups according to their performance in the use of Diskus device: effective and ineffective. RESULTS: Twenty-nine patients who completed the study showed a negative correlation between the cognitive test scores and Diskus training parameters. The number of errors and duration of training increased as the cognitive scores decreased. In Visit 2, a comparison between patients with ineffective and effective use of the Diskus device showed that cognitive function scores were higher in those with effective use. CONCLUSIONS: Evaluation of cognitive functions in COPD patients is important in establishing an effective inhalation treatment.Öğe The Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseases(2009) Bekçi, Taha; Kurtipek, Ercan; Kesli, Recep; Maden, Emin; Teke, TurgutAim: To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-? (TNF-?), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods: Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and sputum was induced. Results: There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-?, MPO levels is similar compared with pretreatment levels. Conclusion: In this study, anti-inflammatory effects of telithromycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings.Öğe Relationship between the ability to learn dry-powder inhaler use and the cognitive functions in patients with COPD(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2015) Tulek, Baykal; Atalay, Nart Bedin; Kurtipek, Ercan; Yildirim, Gulfem; Kanat, Fikret; Suerdem, Mecit[Abstract not Available]
