The Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseases
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-? (TNF-?), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods: Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and sputum was induced. Results: There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-?, MPO levels is similar compared with pretreatment levels. Conclusion: In this study, anti-inflammatory effects of telithromycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings.
Açıklama
Anahtar Kelimeler
Chronic obstructive pulmonary diseases, Interleukin-8, Myeloperoxidase, Telithromycin, Tumor necrosis factor-alpha.
Kaynak
European Journal of General Medicine
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
6
Sayı
4
Künye
Bekçi, T., Kurtipek, E., Kesli, R., Maden, E., Teke, T., (2009). The Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseases. European Journal of General Medicine, 6(4), 218-222.
