The Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseases

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dc.contributor.authorBekçi, Taha
dc.contributor.authorKurtipek, Ercan
dc.contributor.authorKesli, Recep
dc.contributor.authorMaden, Emin
dc.contributor.authorTeke, Turgut
dc.date.accessioned2020-03-26T17:45:54Z
dc.date.available2020-03-26T17:45:54Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-? (TNF-?), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods: Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and sputum was induced. Results: There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-?, MPO levels is similar compared with pretreatment levels. Conclusion: In this study, anti-inflammatory effects of telithromycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings.en_US
dc.identifier.citationBekçi, T., Kurtipek, E., Kesli, R., Maden, E., Teke, T., (2009). The Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseases. European Journal of General Medicine, 6(4), 218-222.
dc.identifier.endpage222en_US
dc.identifier.issn1304-3889en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24201
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorMaden, Emin
dc.institutionauthorTeke, Turgut
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChronic obstructive pulmonary diseasesen_US
dc.subjectInterleukin-8en_US
dc.subjectMyeloperoxidaseen_US
dc.subjectTelithromycinen_US
dc.subjectTumor necrosis factor-alpha.en_US
dc.titleThe Effect of Telithromycin on Inflammatory Markers in Chronic Obstructive Pulmonary Diseasesen_US
dc.typeArticleen_US

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