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Öğe Amitraz Poisoning in Children(Springer-Verlag, 2002) Aydin, Kürşad; Per, Hüseyin; Kurtoğlu, Selim; Poyrazoğlu, Muammer Hakan; Narin, Nazmi; Aslan, DuranThere is no information available in the general paediatric literature about amitraz poisoning. In the present study, which is the largest series in the literature, we report 24 children with amitraz poisoning.Öğe Arterial Wall Thickening and Stiffening in Children and Adolescents with Type 1 Diabetes(Elsevier Ireland Ltd, 2006) Atabek, Mehmet Emre; Kurtoğlu, Selim; Pirgon, Özgür; Baykara, MuratObjective: We evaluated structural and functional characteristics of the common carotid artery (CCA), a marker of early carotid atherosclerosis, and investigated their relation to metabolic and anthropometric parameters in children and adolescents with type 1 diabetes. Materials and methods: Non-invasive ultrasonographic measurements were made in 45 type I diabetic patients and 33 controls. Age, sex, and body mass index were matched between patients and controls. We investigated intima-media thickness (IMT), compliance, distensibility, diastolic wall stress (DWS) and incremental elastic modulus (IEM) of the CCA. Metabolic and anthropometric parameters such as serum lipids, plasma glycated haemoglobin, body mass index, waist-hip ratio and blood pressure were assessed. Results: The diabetic patients had significantly higher CCA-IMT than the controls (0.48 +/- 0.06 mm versus 0.33 +/- 0.07 mm; p < 0.001). The diabetic children had significantly higher values than the controls for DWS (1.18 +/- 0.29 mmHg x 102 versus 0.81 +/- 0.25 mmHg x 10(2); p < 0.001) and for IEM (1.26 +/- 0.57 mmHg x 10(3) versus 0.77 +/- 0.28 mmHg x 10(3); P < 0.001). The difference was not significant between patients and controls for arterial compliance and for distensibility (p > 0.05). In a multivariate regression model for all subjects, diabetic state was the best predictor of IMT (p < 0.001), DWS (p < 0.001) and IEM (p = 0.001). Conclusion: Our results suggested that children and adolescent patients with type I diabetes are associated with early impairment of CCA structure and function and that diabetic state may be the main risk factor for CCA wall stiffening and thickening, which are of considerable concern as possible early events in the genesis of atheroma.Öğe Assessment of Abnormal Glucose Homeostasis and İnsulin Resistance in Turkish Obese Children and Adolescents(Karger, 2007) Atabek, Mehmet Emre; Pirgon, Özgür; Kurtoğlu, SelimBackground: The worldwide increase in the prevalence of childhood obesity is reaching epidemic proportions and is associated with a dramatic rise in cases of type 2 diabetes. We determined the prevalence of impaired glucose regulation and insulin resistance in obese children and adolescents. Methods: A total of 196 obese children [SD score (SDS) of body mass index (BMI): 2.17 0.03], aged 7–18 years, including 86 male subjects, underwent an oral glucose tolerance test (1.75 g glucose/kg body weight). We used the modified WHO criteria adapted for children for abnormal glucose homeostasis. Homeostasis model assessment was used to estimate insulin resistance in all subjects. The insulin sensitivity index was also determined in subjects. Results: Of the total of 196 obese children, 15 (6.6%) had an abnormal fasting glucose level. Of the 196 obese children, 35 (18%) had impaired glucose tolerance (IGT) and 83 (43%) had insulin resistance. Of the 196 obese children were six (3%) diagnosed with type 2 diabetes. Insulin resistance indices were correlated well with the degree of abnormal glucose tolerance. Conclusions: IGT, insulin resistance and type 2 diabetes are far more common in obese Turkish children than previously thought. Early treatment in obese children and adolescents with IGT constitutes a strategy of reversing the progression to b-cell failure and preventing type 2 diabetes.Öğe Effects of Phototherapy on the Growth Plate in Newborn Rats(Lippincott Williams & Wilkins, 2006) Atabek, Mehmet Emre; Pirgon, Özgür; Kurtoğlu, Selim; Tavlı, Lema; Esen, H. Hasan; Köylü, Öznur; Erkul, İbrahimThe aim of the present study was to evaluate the effect of phototherapy and oxidative stress on the growth plate of newborn rats. Forty newborn Sprague-Dawley rats were randomized into a phototherapy group and a control group. Twenty of the rats received phototherapy for 7 days. All zones of the growth plate were assessed with quantitative histomorphometric analysis. Individual zonal lengths were measured for the reserve zone (RZ), the proliferative zone (PZ), the hypertropbic zone (HZ), ossifying cartilage (OC), and total zone (TZ) of the growth plate. Levels of plasma malondialdehyde (MDA), an index of oxidative stress, were also evaluated. Compared with zonal lengths on day 7 after phototherapy between the two groups, the phototherapy group had significantly lower values than those of controls for RZ (5.13 +/- 0.36 vs. 6.4 +/- 0.85 mm X 10(-2); P < 0.001), PZ (20.6 +/- 3.0 vs. 29.25 +/- 1.68 mm X 10(-2); p < 0.001), HZ (15.4 +/- 1.44 vs. 20.87 +/- 1.12 mm X 10(-1); P < 0.001), OC (47.08 +/- 4.25 vs. 62.06 +/- 3.7 mm X 10(-2); p < 0.001), and TZ (88.15 +/- 6.56 vs. 118.48 +/- 4.50 mm X 10(-2); p < 0.001). Plasma MDA levels were correlated with the size of the PZ in the phototherapy group (r = -0.53, P = 0.01). In a multivariate regression model for all rats, being in the phototherapy group was the best predictor of the size of the TZ (beta = -0.94, P < 0.001), with the total variance explained being 88%. These results suggest that in newborn rats, receiving phototherapy is associated with early impairment of growth plate structure, and oxidative stress may be the main risk factor for growth plate injury.Öğe Growth Retardation in Children With Iga Deficiency(Freund Publishing House Ltd, 2002) Patıroğlu, Türkan; Aydın, Kürşad; Kurtoğlu, Selim; Poyrazoğlu, HakanWe evaluated the clinical and immunological manifestations of 14 children with IgA deficiency. Four of the patients were asymptomatic, and ten were symptomatic, with recurrent sino-pulmonary infections, allergic disease, recurrent intestinal giardiasis or celiac disease. Growth retardation was the second important feature in our patients. One of the seven patients with growth retardation had partial growth hormone deficiency. The levels of serum IgG and IgM were high in five and three patients, respectively. Cellular immunity was normal.Öğe Insulin-like Growth Factor-i and Insulin-like Growth Factor Binding Protein-3 Levels of Children Living in an Iodine- and Selenium-deficient Endemic Goiter Area(HUMANA PRESS INC, 2002) Aydın, Kürşad; Bideci, Aysun; Kendirci, Mustafa; Cınaz, Peyami; Kurtoğlu, SelimSerum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels were investigated in 31 children living in an endemic goiter area and 33 healthy subjects living in an nonendemic area. Serum lGF-I and IGFBP-3 levels of iodine- and selenium deficient children were found to be lower than those of control subjects (p<0.001). There was a positive correlation between the IGF-I with chronological age and body mass index. There was also positive correlation between the lGF-I and IGFBP-3. No significant difference was found between the goitrous and nongoitrous children. These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter.Öğe Iodine and Selenium Deficiency in School-Children in an Endemic Goiter Area in Turkey(FREUND PUBLISHING HOUSE LTD, 2002) Aydın, Kürşad; Kendirci, Mustafa; Kurtoğlu, Selim; Karaküçük, E. İnci; Kırış, AdemEndemic goiter is one of the most important health problems in Turkey. However, there are not enough studies associated with iodine and selenium status. This study was carried out to establish the effects of iodine and selenium levels on thyroid gland size and thyroid functions in 73 healthy school-children, 7-12 years old (mean 9.56 +/- 1.77 years), 38 girls (52%) and 35 boys (48%), living in an endemic goiter area. Goiter was found in 32 of the children (43.8%) by palpation, and 56 of the children (76.7%) by ultrasonography. Mean serum T-3 and TSH levels were in the upper limit of normal, and mean serum T-4 levels were within the normal limits, but mean serum thyroglobulin levels were higher than the normal limits. Mean serum selenium level was 30.84 +/- 23.04 mug/l, and mean urinary iodine level was 3.91 +/- 3.77 mug/dl, appropriate for moderate iodine and selenium deficiency. Thyroid volumes of the children were negatively correlated with serum selenium levels, but there was no correlation with urinary iodine levels and thyroid hormones. In conclusion, school-children in this area had significant goiter problems, probably due to the iodine and selenium deficiencies.Öğe The Role of Umbilical Cord Blood Insulin Like Growth Factor-1 Levels in the Assessment of Bone Maturation in Term Neonates(2009) Kurtoğlu, Selim; Atabek, Mehmet Emre; Pirgon, Özgür; Hatipoğlu, NihalPurpose: In this study, we aimed to investigate the relation of anthropometric data and knee epiphyseal area with cord blood Insulin Like Growth Factor-1 (IGF-1) levels at birth in term neonates. Material and Method: Twenty-six term neonates were recruited. Anthropometric measures and the knee epiphyseal area were recorded and umbilical cord blood samples were collected at birth. The knee epiphyseal area was calculated by the addition of [width x height x 3.1415/4] of the distal femoral epiphysis and proximal tibia epiphysis. Results: Mean concentrations of IGF-1 levels of cord blood and the knee epiphyseal area were 45.2 ± 36.8 ng/ml and 29.0 ± 18.4 mm2 in term neonates, respectively. IGF-1 levels correlated significantly with knee epiphyseal area (r: 0.45, p: 0.018). In a multiple regression model, IGF-1 emerged as independent correlates for mean knee epiphyseal area in term neonates with the total variance being 18 %. Although IGF-1 level had significantly positive correlations with body surface area, birth weight, midarm circumference did not correlate with gestational age, birth length, head circumference, ponderal index and skinfold thickness. Conclusion: Cord blood IGF-1 level is useful for assessing the bone maturation in neonates, because a changes in IGF-1 correlates with the change in epiphyseal area.
