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Öğe Complex-valued wavelet artificial neural network for Doppler signals classifying(ELSEVIER SCIENCE BV, 2007) Ozbay, Yuksel; Kara, Sadik; Latifoglu, Fatma; Ceylan, Rahime; Ceylan, MuratObjective: In this paper, the new complex-valued wavelet artificial neural network (CVWANN) was proposed for classifying Doppler signals recorded from patients and healthy volunteers. CVWANN was implemented on four different structures (CVWANN-1, -2, -3 and -4). Materials and methods: In this study, carotid arterial Doppler ultrasound signals were acquired from left carotid arteries of 38 patients and 40 healthy volunteers. The patient group had an established diagnosis of the early phase of atherosclerosis through coronary or aortofemoropopliteal angiographies. In implemented structures in this paper, Haar wavelet and Mexican hat wavelet functions were used as real and imaginary parts of activation function on different sequence in hidden layer nodes. CVWANN-1, -2 -3 and -4 were implemented by using Haar-Haar, Mexican hat-Mexican hat, Haar-Mexican hat, Mexican hat-Haar as real-imaginary parts of activation function in hidden layer nodes, respectively. Results and conclusion: In contrast to CVWANN-2, which reached classification rates of 24.5%, CVWANN-1, -3 and -4 classified 40 healthy and 38 unhealthy subjects for both training and test phases with 100% correct classification rate using leave-one-out cross-validation. These networks have 100% sensitivity, 100% specifity and average detection rate is calculated as 100%. In addition, positive predictive value and negative predictive value were obtained as 100% for these networks. These results shown that CVWANN-1, -3 and -4 succeeded to classify Doppler signals. Moreover, training time and processing complexity were decreased considerable amount by using CVWANN-3. As conclusion, using of Mexican hat wavelet function in real and imaginary parts of hidden Layer activation function (CVWANN-2) is not suitable for classifying healthy and unhealthy subjects with high accuracy rate. The cause of unsuitability (obtaining the poor results in CVWANN-2) is tack of harmony between type of activation function in hidden layer and type of input signals in neural network. (c) 2007 Elsevier B.V. All rights reserved.Öğe Diagnosis of atherosclerosis from carotid artery Doppler signals as a real-world medical application of artificial immune systems(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Latifoglu, Fatma; Sahan, Seral; Kara, Sadik; Gunes, SalihIn this study, we have employed the maximum envelope of the carotid artery Doppler sonograms derived from Fast Fourier Transformation-Welch Method and artificial immune systems in order to distinguish between atherosclerosis and healthy subjects. In this classification problem, the used artificial immune system has reached to 99.33% classification accuracy using 10-fold Cross Validation (CV) method with only two system units which reduced classification time considerably. This success shows that whereas artificial immune systems is a new research area, one can utilize from this new field to reach high performance for his problem. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Medical application of artificial immune recognition system (AIRS): Diagnosis of atherosclerosis from carotid artery Doppler signals(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Latifoglu, Fatma; Kodaz, Halife; Kara, Sadik; Gunes, SalihThis study was conducted to distinguish between atherosclerosis and healthy subjects. Hence, we have employed the maximum envelope of the carotid artery Doppler sonogrants derived from Fast Fourier Transformation-Welch method and Artificial Immune Recognition System (AIRS). The fuzzy appearance of the carotid artery Doppler signals makes physicians suspicious about the existence of diseases and sometimes causes false diagnosis. Our technique gets around this problem using AIRS to decide and assist the physician to make the final judgment in confidence. AIRS has reached 99.29% classification accuracy using 10-fold cross validation. Results show that the proposed method classified Doppler signals successfully. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Medical diagnosis of atherosclerosis from Carotid Artery Doppler Signals using principal component analysis (PCA), k-NN based weighting pre-processing and Artificial Immune Recognition System (AIRS)(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008) Latifoglu, Fatma; Polat, Kemal; Kara, Sadik; Guenes, SalihIn this study, we proposed a new medical diagnosis system based on principal component analysis (PCA), k-NN based weighting preprocessing, and Artificial Immune Recognition System (AIRS) for diagnosis of atherosclerosis from Carotid Artery Doppler Signals. The suggested system consists of four stages. First, in the feature extraction stage, we have obtained the features related with atherosclerosis disease using Fast Fourier Transformation (FFT) modeling and by calculating of maximum frequency envelope of sonograms. Second, in the dimensionality reduction stage, the 61 features of atherosclerosis disease have been reduced to 4 features using PCA. Third, in the pre-processing stage, we have weighted these 4 features using different values of k in a new weighting scheme based on k-NN based weighting pre-processing. Finally, in the classification stage, AIRS classifier has been used to classify subjects as healthy or having atherosclerosis. Hundred percent of classification accuracy has been obtained by the proposed system using 10-fold cross validation. This success shows that the proposed system is a robust and effective system in diagnosis of atherosclerosis disease. (C) 2007 Elsevier Inc. All rights reserved.Öğe A new supervised classification algorithm in artificial immune systems with its application to carotid artery Doppler signals to diagnose atherosclerosis(ELSEVIER IRELAND LTD, 2007) Ozsen, Seral; Kara, Sadik; Latifoglu, Fatma; Gunes, SalihBecause of its self-regulating nature, immune system has been an inspiration source for usually unsupervised learning methods in classification applications of Artificial Immune Systems (AIS). But classification with supervision can bring some advantages to AIS like other classification systems. Indeed, there have been some studies, which have obtained reasonable results and include supervision in this branch of AIS. In this study, we have proposed a new supervised AIS named as Supervised Affinity Maturation Algorithm (SAMA) and have presented its performance results through applying it to diagnose atherosclerosis using carotid artery Doppler signals as a real-world medical classification problem. We have employed the maximum envelope of the carotid artery Doppler sonograms derived from Autoregressive (AR) method as an input of proposed classification system and reached a maximum average classification accuracy of 98.93% with 10-fold cross-validation method used in training-test portioning. To evaluate this result, comparison was done with Artificial Neural Networks and Decision Trees. Our system was found to be comparable with those systems, which are used effectively in literature with respect to classification accuracy and classification time. Effects of system's parameters were also analyzed in performance evaluation applications. With this study and other possible contributions to AIS, classification algorithms with effective performances can be developed and potential of AIS in classification can be further revealed. (C) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Pattern detection of atherosclerosis from Carotid Artery Doppler Signals using fuzzy weighted pre-processing and Least Square Support Vector Machine (LSSVM)(SPRINGER, 2007) Polat, Kemal; Kara, Sadik; Latifoglu, Fatma; Gunes, SalihCarotid Artery Doppler Signals were recorded from 114 subjects, 60 of whom had Atherosclerosis disease while the rest were healthy controls. Diagnosis of Atherosclerosis from Carotid Artery Doppler Signals was conducted using Fuzzy weighted pre-processing and Least Square Support Vector Machine (LSSVM). First, in order to determine the LSSVM inputs, spectral analysis of Carotid Artery Doppler Signals was performed via Autoregressive (AR) modeling. Then, fuzzy weighted pre-processing based is proposed expert system, applied to inputs obtained from spectral analysis of Carotid Artery Doppler Signals. LSSVM was used to detect Atherosclerosis from Carotid Artery Doppler Signals. All data set were obtained from Carotid Artery Doppler Signals of healthy subjects and subjects suffering from Atherosclerosis disease. The employed expert system has achieved 100% classification accuracy using a 10-fold Cross Validation (CV) method.Öğe Usage of a novel, similarity-based weighting method to diagnose atherosclerosis from carotid artery Doppler signals(SPRINGER HEIDELBERG, 2008) Polat, Kemal; Latifoglu, Fatma; Kara, Sadik; Guenes, SalihIn this paper, we have proposed a novel similarity-based weighting method (SBWM), which combines similarity measure and weighting based on trend association (WBTA) method proposed by Sun Yi et al. (ICNN&B international conference, vol 1, pp 266-269, 2005). The aim of this study is to improve the classification accuracy of atherosclerosis, which is a common disease among the public. The proposed method consists of three parts: (1) feature extraction part related with atherosclerosis disease using fast Fourier transformation (FFT) modeling and calculation of maximum frequency envelope of sonograms, (2) data pre-processing part using SBWM, including different similarity measures such as cosine amplitude method, max-min method, absolute exponential method, and exponential similarity coefficient, and (3) classification part using artificial immune recognition system (AIRS) and Fuzzy-AIRS classifier algorithms. While AIRS and Fuzzy-AIRS algorithms obtained 71.92 and 78.94% success rates, respectively, the combination of SBWM with classifier algorithms including AIRS and Fuzzy-AIRS obtained 100% success rate on all the similarity measures. These results show that SBWM has produced very promising results in the classification of atherosclerosis from carotid artery Doppler signals. In future, we will use a larger dataset to test the proposed method.