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Öğe Acute-Phase Proteins, Oxidative Stress and Enzyme Activities of Blood Serum and Peritoneal Fluid in Cattle with Abomasal Displacement(WILEY, 2012) Maden, M.; Ozturk, A. S.; Bulbul, A.; Avci, G. E.; Yazar, E.Background Blood serum and peritoneal fluid acute-phase proteins, oxidative stress indicators, and some enzymes could be used for evaluation of abomasal tissue damage because of displacement in displaced abomasum (DA) cases. Objectives The aim of this study was to investigate the concentrations of acute-phase proteins, oxidative stress indicators, and activities of enzymes in blood serum and peritoneal fluid in cattle with right displaced abomasum (RDA) and left displaced abomasum (LDA) and in healthy cows. Animals A total of 60 Holstein Friesian cows in early lactation were used, 31 with left and 9 with right displaced abomasum without volvulus diagnosis and no other postpartum disease, and 20 healthy cows as a control. Materials and Methods DA diagnosis in dairy cows consisted of physical examination, laboratory, and specific DA tests. Acute-phase proteins, oxidative stress indicators, and enzyme activities were measured in blood serum and peritoneal fluid. Results In the RDA group, serum haptoglobin (HPG), serum amyloid A (SAA), malondialdehyde (MDA), adenosine deaminase (ADA), myeleperoxidase (MPO), aspartate aminotransferase (AST), creatine kinase (CK, creatine kinaseMB (CK-MB), and gamma-glutamyl transferase (GGT) activity increased significantly, and serum HPG, MDA, ADA, and AST concentrations increased significantly in the LDA group (P < .05). Peritoneal fluid HPG, MDA, ADA, MPO, ALP, GGT, and LDH concentrations increased significantly, whereas NO concentrations reduced significantly in the RDA group, and HPG, MDA, ADA, and TP concentrations increased significantly, whereas concentrations of NO reduced significantly in the LDA group (P < .05). Conclusions and Clinical Importance There are acute-phase responses, oxidative stress, and abomasal tissue damage because of displacement in DA cases. Especially, HPG, MDA, ADA, and MPO concentrations can provide specific information to help in understanding these changes.Öğe Clinical efficiency of Doxorubicin and Cisplatin in treatment of transmissible venereal tumor of bitches(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2012) Cizmeci, S. U.; Kose, A. M.; Aydin, I.; Dinc, D. A.; Maden, M.; Kose, S. I.The aim of this study was to evaluate the clinical efficiency of doxorubicin and cisplatin, which are used successfully in treatments of genital organ tumors in humans and Transmissible Venereal Tumor (TVT) in bitches. Bitches with TVT (n=17) were included in the study and they were from different breeds, age groups and body weight. Doxorubicin (DOX, 30 mg/m(2), n=9) and cisplatin (CIS, 70 mg/m(2), n=8) were administered to bitches for TVT treatment. Treatment protocol was repeated for 5 times with intervals of 21 days. Hematology, blood gases and serum biochemistry analyses were performed on blood samples collected before and 24 hours after each chemotherapy. Tumor was completely regressed in the animals in DOX group following fifth treatment. Six bitches died in CIS group during treatment. There were no signs of tumor regression in the remaining 2 bitches after third treatment in CIS group. There were leucocytosis and normocytic-hypochromic anemia in all the dogs involved in the therapy. There were significant increases (P<0.05) in blood urea nitrogen (BUN), aspartate aminotransferase (AST) and triglyceride (TRI) concentrations of CIS group and BUN, AST and creatinine phosphokinase (CPK) concentrations of doxorubicin group. It was concluded that cisplatin is ineffective while doxorubicin is effective and can be used safely in treatment of TVT in bitches.Öğe Evaluation of different chemotherapy agents on well-being of bitches with transmissible venereal tumor (TVT)(WILEY-BLACKWELL, 2011) Cizmeci, S. U.; Kose, M.; Dinc, D.; Maden, M.; Aydin, I.; Kose, S.[Abstract not Available]Öğe The evaluation of hemostatic dysfunction and disseminated intravascular coagulation in dairy cows with abomasal displacement(POLSKA AKAD NAUK, POLISH ACAD SCIENCES, UNIV WARMIA & MAZURY OLSZTYN, 2018) Maden, M.; Yildiz, R.; Col, R.; Arican, M.; Ider, M.; Garip, M.; Tras, B.Disseminated intravascular coagulation (DIC) is a complex, dynamic and hemostatic disorder which develops secondarily to a disease characterized with an imbalance in the pro-coagulant and anti-coagulant components of hemostasis. The aim of the study is to evaluate hemostatic dysfunction and the DIC syndrome in cattle with displaced abomasum (DA), with using the hematologic analyses and an extensive coagulation profile in the 96 hour-period including before and after surgery. The animal material of the study consisted of 12 dairy cows diagnosed with displaced abomasum (9 LDA and 3 RDA without volvulus) in the 2-4 week period after parturation and with no other post-partum disease. In dairy cows diagnosed with DA, hematological, coagulometric (PT, APTT, Fibrinogen) and coagulation factor analyses [D-Dimer, TAT (thrombin-antithrombin complex), ATIII (antithrombin III), PAI-1 (plazminogen activator inhibitor-1] were performed in blood samples obtained before the operation as well as 30 minutes, 60 minutes and 2, 5, 10, 24, 48, 72 and 96 hours after the operation. In the DA cases, abnormalities were found in 6 of the 8 coagulation parameters. In the LDA and RDA groups, prolonged PT (sec), PT (INR) and APTT, hypofibrinogenemia, an increase in serum D-Dimer concentration at 72 and 96 hours after the operation and an increase in serum ATIII concentrations before and 30, 60 minutes and 2, 5, 72 and 96 hours after the operation was found (p<0.05). Hemostatic dysfunction and the risk of DIC developing in DA cases and continuing in the post-operative period was determined.Öğe Idioventricular Rhythm in A Calf Suffering From Diarrhea(Scientific and Technical Research Council of Turkey, 1996) Başoğlu, A.; Sevinç, M.; Maden, M.Electrocardiographic examination of a seven-day-old Holstein calf suffering from diarrhea revealed evidence of idioventricular rhythm with wide aberrant QRS complexes and T waves. In the present case, which involved severe metabolic acidosis and hyperkalemia, after the acid-base and electrolyte imbalance were corrected solely by fluid therapy (physiologic sodium Chlorid and dextrose solutions with bicarbonate), sinus rhythm was recorded.Öğe Investigation of Biochemical and Haematological Side-Effects of Enrofloxacin in Dogs(BLACKWELL WISSENSCHAFTS-VERLAG GMBH, 2001) Traş, B.; Maden, M.; Baş, A. L.; Elmas, M.; Yazar, E.; Civelek, T.In the present study, effects of enrofloxacin on biochemical, haematological and blood gas parameters were investigated. Changes in laboratory parameters were monitored during the treatment period. Enrofloxacin was administered (5 mg/kg intramuscularly, once daily) to 10 healthy dogs for 14 days. Acidosis and temporary increases in aspartate aminotransferase, indirect bilirubin, sodium, partial pressure of CO2 and mean corpuscular volume levels as well as decreased levels of inorganic phosphorus, ionized calcium, potassium, partial pressure of O-2 and standard bicarbonate were observed. The results of this study suggest that these observed effects of enrofloxacin on blood gas parameters should be taken into consideration in long-term use of the drug.Öğe Ultrasonographic Evaluation of Kidney Damage in Dog with Gentamicin Nephrotoxicity(1996) Turgut, K.; Maden, M.; Şen, I.; Çiftçi, M. KemalAcute tubular necrosis was induced by experimental gentamicin nephrotoxicity to follow and describe the changes in ultrasonographic appearance of the kidney. Sonograms were evaluated for information on size, shape and renal structure, specifically including focal, multifocal, or diffuse alterations in renal cortical, medullar, sinusal and perinephric echogenity and intensity (compared to that of the splenic and hepatic paranchmys). Following 12 hours of no feeding, clinical, biochemical and ultrasonographic examinations were conducted and then gentamicin sulphate (10 mg/kg body weight, t.i.d.) was injected for 10 consecutive days. The clinical states of the dogs were observed, and urine dip stick examinations, microscopic examination of urine sediment biochemical [blood: BUN, serum creatinine (CR), albumin PO4-,Na+,K+ concentrations; urine: total protein (TP) and creatinine concentrations, N-acetyl-?-D-glucosaminidase (NAG), ?-glutamly transferase (GGT), alkaline phosphates (ALP) activities and their creatinine rations, fractional clearences of Ca2+, PO4-, Na+,K+] analysis and ultrasonographic examinations of the kidneys were performed every other day for 15 days. Heamaturia, proteinuria, glucosuria and granular casts in the microscopic examination of urine sediment were first determined on the 8th day of the experiment BUN, serum CR and PO4- and K+ concentrations were significantly increased on the 3rd, 9th, and 13th days of the experiment respectively (p<0.01). Significant decreases in serum albumin and Na+ concentrations were respectively determined on the 7th and 9th days of te experiment (p<0.01). The urine TP/CR rate had significantly increased on the 9th day of the experimet (p<0.01). Significant increases in the GGT/CR (p<0.01). NAG/CR (p<0.01) and ALP/CR (p<0.05) rates were respectively observed on the 7th and 13th days of the experiment. Significant increases in the fractional clearances of PO4-, Ca2+, K+ and Na+ were respectively determined on the 7th, 9th and 13th days of the experiment (p<0.01). Characteristic ultrasonographic changes were observed in all dogs after the 8th day of the experiment The longitudinal and transversal length of both kidneys increased respectively from 5.79±0.18 cm and 3.05±0.15 cm for the left kidney, and 6.09±0.35 cm and 3.28±0.19 cm for the right kidney before the experiment, to 6.84±0.46 cm and 3.93±0.18 cm for the left and 6.34±0.53 cm and 3.99±0.49 cm for the right on the 11th day of the experiment. Hyperechoic cortex (compared to that spleen and liver) with distinguishable normal hypoechoic medullar papilla was determined. There was an enhancement in corticomedullar demarcation No focal or multifocal alterations were observed. On the basis of this study, nephrosonography seems to be a reliable method for detecting diffuse renal alterations (tubular nephrosis) and diagnosing diffuse renopathies in clinical cases.
