Clinical efficiency of Doxorubicin and Cisplatin in treatment of transmissible venereal tumor of bitches
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ECOLE NATIONALE VETERINAIRE TOULOUSE
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to evaluate the clinical efficiency of doxorubicin and cisplatin, which are used successfully in treatments of genital organ tumors in humans and Transmissible Venereal Tumor (TVT) in bitches. Bitches with TVT (n=17) were included in the study and they were from different breeds, age groups and body weight. Doxorubicin (DOX, 30 mg/m(2), n=9) and cisplatin (CIS, 70 mg/m(2), n=8) were administered to bitches for TVT treatment. Treatment protocol was repeated for 5 times with intervals of 21 days. Hematology, blood gases and serum biochemistry analyses were performed on blood samples collected before and 24 hours after each chemotherapy. Tumor was completely regressed in the animals in DOX group following fifth treatment. Six bitches died in CIS group during treatment. There were no signs of tumor regression in the remaining 2 bitches after third treatment in CIS group. There were leucocytosis and normocytic-hypochromic anemia in all the dogs involved in the therapy. There were significant increases (P<0.05) in blood urea nitrogen (BUN), aspartate aminotransferase (AST) and triglyceride (TRI) concentrations of CIS group and BUN, AST and creatinine phosphokinase (CPK) concentrations of doxorubicin group. It was concluded that cisplatin is ineffective while doxorubicin is effective and can be used safely in treatment of TVT in bitches.
Açıklama
Anahtar Kelimeler
Transmissible venereal tumor, bitches, Doxorubicin, Cisplatin
Kaynak
REVUE DE MEDECINE VETERINAIRE
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
163
Sayı
11
