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Öğe Chandler syndrome manifesting as ectropion uvea following laser in situ keratomileusis(ELSEVIER SCIENCE INC, 2008) Mocan, Mehmet C.; Bozkurt, Banu; Orhan, Mehmet; Irkec, MuratWe report the case of a 30-year-old woman with recent onset of unilateral iris distortion and glaucoma that was noticed following uneventful laser in situ keratomileusis (LASIK). The corneal endothelium in the right eye appeared normal with the slitlamp microscope, and LASIK-related anterior segment ischemia was initially considered in the differential diagnosis. However, in vivo confocal microscopy revealed abnormal endothelial cells, confirming the diagnosis of iridocorneal endothelial syndrome. In patients having refractive corneal procedures, in vivo confocal microscopy is recommended to diagnose preexisting corneal abnormalities that might otherwise remain undetected.Öğe Elevated Tear Interleukin-6 and Interleukin-8 Levels in Patients With Conjunctivochalasis(LIPPINCOTT WILLIAMS & WILKINS, 2009) Erdogan-Poyraz, Ceren; Mocan, Mehmet C.; Bozkurt, Banu; Gariboglu, Semra; Irkec, Murat; Orhan, MehmetPurpose: To determine the interleukin (IL)-6 and IL-8 levels in the tear samples of patients with conjunctivochalasis (CCh) and to correlate the severity of symptoms with tear IL levels. Methods: Fifty-one eves at different stages of CCh and 10 eves of healthy controls were recruited for this prospective Study undertaken at a single university-based hospital. CCh was graded based on the extent of interior lid margin involvement as follows: 1 = single (temporal) location. 2 = 2 locations, and 3 = whole lid. The presence of punctal occlusion and fluorescein clearance patterns were recorded. Enzyme-linked immunosorbent assay was used to determine IL levels. Severity of symptoms was assessed With the Ocular Surface disease index. Results: of the 5 1 study patients (mean age = 63.4 +/- 6.9 years), 16 had grade 1.21 had grade 2. and 14 had grade 3 CCh. Tear IL-6 and IL-8 levels were significantly higher in patients with CCh than in controls (P <= 0.001). Higher IL levels were observed in grades 2 and 3 CCh than in grade 1 CCh and control eyes (P < 0.001). Patients with CCh who also had punctal occlusion and delayed fluorescein clearance results had higher tear IL levels than those who did not (P <= 0.001). Tear IL levels were positively correlated with the clinical severity of CCh as evaluated with the ocular Surface disease index (r = 0.826. P < 0.001 for IL-6 and r = 0.726, P < 0.001 for IL-8). Conclusions: Inflammation may have a role in the pathogenesis of CCh. The clinical severity of CCh parallels the increased tear IL levels. Markers for inflammation are more pronounced in the advanced stages of this disease.Öğe In Vivo Confocal Microscopic Findings in Posterior Polymorphous Corneal Dystrophy(LIPPINCOTT WILLIAMS & WILKINS, 2013) Bozkurt, Banu; Irkec, Murat; Mocan, Mehmet C.Purpose: To describe the corneal findings in posterior polymorphous corneal dystrophy (PPCD) as imaged with laser scanning in vivo confocal microscopy (IVCM).Methods: IVCM images of 7 subjects with PPCD who had typical slit-lamp biomicroscopic findings of endothelial vesicular, band, and/or placoid lesions were evaluated.Results: Five women and 2 men aged 7 to 64 years were included in this study. Laser scanning IVCM (Heidelberg Retina Tomograph II, Rostock Cornea Module) revealed hyporeflective, round, vesicular lesions with diameters ranging between 20 and 200 mu m in 3 subjects, combined vesicular and curvilinear hyperreflective band-like lesions in 3 subjects, and combined vesicular and placoid hyperreflective lesions in 1 subject at the level of Descemet membrane (DM), endothelial cell layer, and posterior stroma adjacent to DM. One subject had coassociated epithelial basement membrane dystrophy. Additional findings included posterior stromal keratocytes with elongated spindle-like nucleus, giant and nucleated endothelial cells, endothelial deposits, and guttae-like dark spots. The mean endothelial cell density was 1485.7 +/- 486.3 cells per square millimeter (range, 990-2365 cells/mm(2)). The mean central corneal thickness was 585.3 +/- 37.17 m (range, 534-643 m).Conclusions: Laser scanning IVCM is able to highlight the characteristic microstructural alterations at the level of endothelium and DM in the setting of PPCD and may have diagnostic utility in equivocal cases with borderline biomicroscopic findings. The possible association of PPCD with epithelial basement membrane dystrophy warrants further investigation.Öğe New Treatment Option for Adult-Onset Limbal Xanthogranuloma(LIPPINCOTT WILLIAMS & WILKINS, 2010) Mocan, Mehmet C.; Bozkurt, Banu; Orhan, Diclehan; Kuzey, Gamze; İrkeç, Murat[Abstract not Available]
