Elevated Tear Interleukin-6 and Interleukin-8 Levels in Patients With Conjunctivochalasis
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
LIPPINCOTT WILLIAMS & WILKINS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To determine the interleukin (IL)-6 and IL-8 levels in the tear samples of patients with conjunctivochalasis (CCh) and to correlate the severity of symptoms with tear IL levels. Methods: Fifty-one eves at different stages of CCh and 10 eves of healthy controls were recruited for this prospective Study undertaken at a single university-based hospital. CCh was graded based on the extent of interior lid margin involvement as follows: 1 = single (temporal) location. 2 = 2 locations, and 3 = whole lid. The presence of punctal occlusion and fluorescein clearance patterns were recorded. Enzyme-linked immunosorbent assay was used to determine IL levels. Severity of symptoms was assessed With the Ocular Surface disease index. Results: of the 5 1 study patients (mean age = 63.4 +/- 6.9 years), 16 had grade 1.21 had grade 2. and 14 had grade 3 CCh. Tear IL-6 and IL-8 levels were significantly higher in patients with CCh than in controls (P <= 0.001). Higher IL levels were observed in grades 2 and 3 CCh than in grade 1 CCh and control eyes (P < 0.001). Patients with CCh who also had punctal occlusion and delayed fluorescein clearance results had higher tear IL levels than those who did not (P <= 0.001). Tear IL levels were positively correlated with the clinical severity of CCh as evaluated with the ocular Surface disease index (r = 0.826. P < 0.001 for IL-6 and r = 0.726, P < 0.001 for IL-8). Conclusions: Inflammation may have a role in the pathogenesis of CCh. The clinical severity of CCh parallels the increased tear IL levels. Markers for inflammation are more pronounced in the advanced stages of this disease.
Açıklama
Anahtar Kelimeler
conjunctivochalasis, interleukin-6, interleukin-8, inflammation
Kaynak
CORNEA
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
28
Sayı
2
