Elevated Tear Interleukin-6 and Interleukin-8 Levels in Patients With Conjunctivochalasis

Basit Öğe Kaydı
dc.contributor.authorErdogan-Poyraz, Ceren
dc.contributor.authorMocan, Mehmet C.
dc.contributor.authorBozkurt, Banu
dc.contributor.authorGariboglu, Semra
dc.contributor.authorIrkec, Murat
dc.contributor.authorOrhan, Mehmet
dc.date.accessioned2020-03-26T17:38:33Z
dc.date.available2020-03-26T17:38:33Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To determine the interleukin (IL)-6 and IL-8 levels in the tear samples of patients with conjunctivochalasis (CCh) and to correlate the severity of symptoms with tear IL levels. Methods: Fifty-one eves at different stages of CCh and 10 eves of healthy controls were recruited for this prospective Study undertaken at a single university-based hospital. CCh was graded based on the extent of interior lid margin involvement as follows: 1 = single (temporal) location. 2 = 2 locations, and 3 = whole lid. The presence of punctal occlusion and fluorescein clearance patterns were recorded. Enzyme-linked immunosorbent assay was used to determine IL levels. Severity of symptoms was assessed With the Ocular Surface disease index. Results: of the 5 1 study patients (mean age = 63.4 +/- 6.9 years), 16 had grade 1.21 had grade 2. and 14 had grade 3 CCh. Tear IL-6 and IL-8 levels were significantly higher in patients with CCh than in controls (P <= 0.001). Higher IL levels were observed in grades 2 and 3 CCh than in grade 1 CCh and control eyes (P < 0.001). Patients with CCh who also had punctal occlusion and delayed fluorescein clearance results had higher tear IL levels than those who did not (P <= 0.001). Tear IL levels were positively correlated with the clinical severity of CCh as evaluated with the ocular Surface disease index (r = 0.826. P < 0.001 for IL-6 and r = 0.726, P < 0.001 for IL-8). Conclusions: Inflammation may have a role in the pathogenesis of CCh. The clinical severity of CCh parallels the increased tear IL levels. Markers for inflammation are more pronounced in the advanced stages of this disease.en_US
dc.identifier.doi10.1097/ICO.0b013e3181861d0cen_US
dc.identifier.endpage193en_US
dc.identifier.issn0277-3740en_US
dc.identifier.issue2en_US
dc.identifier.pmid19158563en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://dx.doi.org/10.1097/ICO.0b013e3181861d0c
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23509
dc.identifier.volume28en_US
dc.identifier.wosWOS:000262844100013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofCORNEAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectconjunctivochalasisen_US
dc.subjectinterleukin-6en_US
dc.subjectinterleukin-8en_US
dc.subjectinflammationen_US
dc.titleElevated Tear Interleukin-6 and Interleukin-8 Levels in Patients With Conjunctivochalasisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu