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Öğe Analysis of chromosomes 8 and 17 aneuploidies in laryngeal squamous cell carcinoma by fluorescence in situ hybridization(WILEY, 2004) Öztürk, Kayhan; Acar, Hasan; Durmuş, Ercan; Öztürk, Adnan; Mutlu, NecipObjectives/Hypothesis: The objectives were to investigate chromosomes 8 and 17 numerical aberrations by using fluorescence in situ hybridization in laryngeal squamous cell carcinoma and also to determine whether there is any association between chromosomes 8 and 17 aneuploidies and TNM classification and subgroups of laryngeal squamous cell carcinomas. Study Design: Descriptive study. Methods: Tumor and control samples were taken from 23 patients with LSCC by surgical operation. Fluorescence in situ hybridization analysis with chromosomes 8- and 17-specific a-satellite DNA probes was performed on the interphase nuclei. Results. The percentages for chromosomes 8 and 17 aneuploidies were 33% (SD = 25.7%) (median value, 26.2%; range, 3.5-81.8%) and 19.2% (SD = 15.8%) (median value, 9.8%; range, 3.6%-63.7%), respectively. There was a significant difference between stage 2 and stage 3 (P < .05) and between stage 2 and stage 4 for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 aneuploidy (P > .05). There was also a significant difference for the T classification for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 (P > .05). Conclusion: Chromosome 8 aneuploidy may be related to stage and T classification of laryngeal squamous cell carcinoma and its progression.Öğe Analysis of chromosomes 8 and 17 aneuploidies laryngeal squamous cell carcinoma by fluorescence in situ hybridization(2004) Öztürk, Kayhan; Acar, Hasan; Durmuş, Ercan; Öztürk, Adnan; Mutlu, NecipObjectives/Hypothesis: The objectives were to investigate chromosomes 8 and 17 numerical aberrations by using fluorescence in situ hybridization in laryngeal squamous cell carcinoma and also to determine whether there is any association between chromosomes 8 and 17 aneuploidies and TNM classification and subgroups of laryngeal squamous cell carcinomas. Study Design: Descriptive study. Methods: Tumor and control samples were taken from 23 patients with LSCC by surgical operation. Fluorescence in situ hybridization analysis with chromosomes 8- and 17-specific ?-satellite DNA probes was performed on the interphase nuclei. Results: The percentages for chromosomes 8 and 17 aneuploidies were 33% (SD = 25.7%) (median value, 26.2%; range, 3.5%-81.8%) and 19.2% (SD = 15.8%) (median value, 9.8%; range, 3.6%-63.7%), respectively. There was a significant difference between stage 2 and stage 3 (P < .05) and between stage 2 and stage 4 for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 aneuploidy (P > .05). There was also a significant difference for the T classification for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 (P > .05). Conclusion: Chromosome 8 aneuploidy may be related to stage and T classification of laryngeal squamous cell carcinoma and its progression.Öğe Effects of Mandibular Symphyseal Distraction Osteogenesis on Mandibular Structures(Mosby-Elsevier, 2006) Malkoç, Sıddık; İşeri, Haluk; Karaman, Ali İhya; Mutlu, Necip; Küçükkolbaşı, HasanIntroduction: The purpose of this study was to evaluate the effects of mandibular symphyseal distraction osteogenesis on dental and mandibular skeletal structures with a tooth- and bone- borne distraction device. Methods: The sample comprised 20 patients, ranging in age from 15.8 to 23.3 years (mean, 20.1 +/- 2.3 years) at the start of treatment. The distraction device was activated 1 mm per day. The device was usually maintained in position about 90 days after surgery. Records were obtained at the start of treatment, at the end of distraction (11.4 +/- 2.2 days after surgery), and at follow-up periods (24.1 +/- 4.2 months after surgery). The records included posteroanterior cephalograms and study casts. The data were analyzed statistically by using the repeated measure analysis of variance and paired t test. Results: Posteroanterior cephalometric analysis demonstrated no significant changes in bigonial widths and ramal angles at the end of distraction period. On the other hand, bimolar widths were significantly increased, whereas bicondylar widths were markedly decreased. The dental cast analysis indicated that the maximum amount of increase was found between the mandibular canines, and the widening effect gradually decreased from the mandibular canines to the second molars. The follow-up data confirmed that the treatment results were stable. Conclusions: The long-term findings indicate that mandibular symphyseal distraction osteogenesis is an efficient nonextraction treatment alternative for mandibular dental crowding to increase mandibular skeletal and dental arch widths.Öğe Evaluation of the Prevalence of Temporomandibular Joint Disorder Syndrome in Dental School Students With Psychometric Analysis(2002) Mutlu, Necip; Herken, Hasan; Güray, Enis; Öz, Fatih; Kalaycı, AbdullahAim: Despite the increasing volume of evidence implicating psychological factors in patients with temporomandibular joint (TMJ) disorder syndrome, these aspects of management are frequently neglected. In the diagnosis and treatment of this syndrome, clinical examination must be accompanied by an evaluation of the patients' emotional condition. In our study, the prevalence of TMJ disorders of dental students and the relation between TMJ disorder syndrome and the emotional condition of the patient were evaluated. Methods: The study group consisted of 156 males and 105 females: a total of 261 students. For the psychometric analysis the Minnesota Multiphasic Personality Inventory (MMPI), Symptom Checklist 90-Revised (SCL 90-R), Beck Depression Scale (BDS), Rosenberg Self-Esteem Scale (RSS), and State Trait Anxiety Inventory I and II (STAI-I and II) tests were used. Standard clinical examination protocol was followed. Results: Psychometric measurements revealed significant psychological differences between subjects with the following TMJ disorder syndrome symptoms: hypochondria, hysteria (MMPI), somatization, and anger (SCL 90-R). In both groups, there were no significant differences between the scales of BDS, RSS and STAI-I and II. Clinical examination revealed internal derangement of 18 male and 18 female students and external derangement of 6 male and 1 female students. Conclusion: In terms of the relation to TMJ disorder syndrome, where it affects the patient's emotional condition, psychiatric support can be very useful in the evaluation and treatment of patients with these complaints.Öğe Histological evaluation of the effects of bioglass, hydroxyapatite, or demineralized freeze-dried bone, grafted alone or as composites, on the healing of tibial defects in rabbits(SAUDI MED J, 2009) Kucukkolbasi, Hasan; Mutlu, Necip; Isik, Kubilay; Celik, Ilhami; Oznurlu, YaseminObjectives: To compare the effectiveness of bioactive glass (BG), natural hydroxyapatite (HA), and demineralized freeze-dried bone (DFDB) in bone defects. Methods: All animal experiments were conducted in Faculty (if Veterinary Medicine, Selcuk University, Konya, Turkey, under the Selcuk University Guidelines for Animal Experimentation, in 2005. Eighteen New Zealand rabbits were used for the experiment. Four cavities were prepared on right and left tibias. The cavities on the right tibia were filled with either BG, HA or DFDB. One cavity was left empty as a control. The cavities on the other tibia] bone were grafted with HA+BG, DFA+DFDB, BG+DFDB and HA+BG+DFDB composites. Histological examinations were performed at first, third, and sixth postoperative months. Results: According to histomorphometric findings, the mixture containing HA+BG+DFDB obtained the best histological results (P<0.05). Conclusion: The composite graft of HA, BG and DFDB is more effective than when used as individual agents.Öğe Mandibular midline distraction using a simple device(MOSBY-ELSEVIER, 2006) Uckan, Sina; Guler, Nurhan; Arman, Ayca; Mutlu, NecipObjective. Mandibular midline distraction osteogenesis represents a new option for creation of intra-arch space in the mandibular arch. The aim of this paper is to introduce a simple device (hyrax expander) and method for mandibular midline distraction. Study design. The sample consisted of 24 patients (mean age: 18.07 years) treated with mandibular midline distraction. Hyrax expanders were used as symphyseal distractors, and distraction procedure was carried out with a rate of I mm and rhythm of twice daily. Results. Mandibular midline distraction was completed successfully in all patients and the distraction amount was 7.01 mm. No major complication other than mild mucosal irritation and gingival recession was observed. Conclusion. The presented method is a viable option for mandibular midline distraction osteogenesis.Öğe Possible Association of Temporomandibular Joint Pain and Dysfunction with a Polymorphism the Serotonin Transporter Gene(MOSBY, INC, 2001) Herken, Hasan; Erdal, Emin; Mutlu, Necip; Barlas, Ömer; Çataloluk, Osman; Öz, Fatih; Güray, EnisThe purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P > .05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P = .003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P = .017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P < .05). The patients who were homozygous for STin 2.10 genotype were also homozygous for "L" genotype (P = .019). However, this was not the condition in the control subjects. This study does not provide evidence to support the involvement of 5-HTT gene-linked polymorphic region in temporomandibular joint pain and dysfunction. Our findings indicated that only the presence of the homozygous STin 2.10 genotype of variable-number tandem-repeat is likely to play a substantial role in the genetic predisposition to temporomandibular joint pain and dysfunction and that the STin 2.12/12 genotype may have a protective role against temporomandibular joint pain and dysfunction.Öğe Six Year Follow-Up of a Patient Treated with Mandibular Symphyseal Distraction Osteogenesis(CHURCHILL LIVINGSTONE, 2010) Şukurica, Yusuf; Gürel, Hakan Gürcan; Mutlu, NecipIn this report, treatment and long term effects of mandibular symphyseal distraction osteogenesis (MSDO) on dentofacial structures are presented. The distraction device used in the present case was a custom made tooth- and bone-borne distractor. Post-treatment records revealed elimination of mandibular anterior crowding, no temporomandibular joint (TMJ) disorder, no periodontal pathology and no root resorption. Follow-tip records taken 6 years after the completion of the treatment indicated no mandibular anterior crowding or TMJ disorder. Treatment and long term results of this case suggest that mandibular widening with distraction osteogenesis is an efficient, safe and stable treatment modality for patients presenting transverse mandibular deficiency and/or mandibular anterior dental crowding. However, large sample studies are required to draw substantial conclusions about the long term effects of the MSDO on dentofacial structures.
