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Öğe The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia(COMENIUS UNIV, 2019) Oc, B.; Arun, O.; Taylan, S. B.; Oc, M.; Bariskaner, H.; Duman, A.OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine. METHODS: The response of human IMA and SV strips with (E+) and without (E-) endothelium subjected to cumulative concentrations of (10(-9), 0(-6) M) dexmedetomidine were recorded at 37 degrees C and at 28 degrees C. OnE-way ANOVA was used for analysis. A p < 0.05 was considered significant. RESULTS: At 37 degrees C dexmedetomidine resulted in similar signifi cant concentration-dependent contractions in both E+ and E-SV strips (p < 0.05). At 37 degrees C dexmedetomidine resulted in signifi cant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E-compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E-at 37 degrees C and also E-28 degrees C groups compared to SV (p < 0.05). CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV graftsÖğe EFFECTS OF UNCONTROLLED DIABETES ON LDL LEVELS OF PATIENTS UNDERGOING CAROTID ENDARTERECTOMY ON AND OFF STATIN THERAPY: PRELIMINARY STUDY(ELSEVIER, 2015) Oc, M.; Duman, I.; Oc, B.; Simsek, M.; Vatansev, H.; Arun, O.; Duman, A.[Abstract not Available]Öğe Prospective ECG-gated high-pitch dual-source cardiac CT angiography in the diagnosis of congenital cardiovascular abnormalities: Radiation dose and diagnostic efficacy in a pediatric population(ELSEVIER MASSON, CORP OFF, 2016) Koplay, M.; Kizilca, O.; Cimen, D.; Sivri, M.; Erdogan, H.; Guvenc, O.; Oc, M.Purpose: The goal of this study was to investigate the radiation dose and diagnostic efficacy of cardiac computed tomography angiography (CCTA) using prospective ECG-gated high-pitch dual-source computed tomography (DSCT) in the diagnosis of congenital cardiovascular abnormalities in pediatric population. Materials and methods: One hundred five pediatric patients who were clinically diagnosed with congenital heart disease with suspected extracardiac vascular abnormalities were included in the study. All CCTAs were performed on a 128 x 2-section DSCT scanner. CCTA findings were compared with surgical and/or conventional cardiac angiography findings. Dose-length product (DLP) and effective doses (ED) were calculated for each patient. Patients were divided into 4 groups by age, and ED and DLP values were compared among groups. The image quality was evaluated using a five-point scale. Results: CCTA showed 173 abnormalities in 105 patients. There were 2 patients with false positive and 3 with false negative findings. The sensitivity and specificity of CCTA were 98.3% and 99.9%, respectively. The positive predictive value and negative predictive value of CCT were 98.9% and 99.9%, respectively. The average DLP and ED values were 15.6 +/- 9.6 (SD) mGy.cm and 0.34 +/- 0.10 (SD) mSv, respectively. The mean image quality score was 4.8 +/- 0.5 (SD) in all patients. The inter-observer agreement for the image quality scores was good (kappa = 0.80). Conclusion: CCTA is an excellent imaging modality for evaluation of cardiovascular abnormalities and provides excellent image quality with very low radiation exposure when low-dose prospective ECG-triggered high-pitch DSCT is used. (C) 2016 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.
