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Öğe ANTHRAX IN UPPER EYELID(NOBEL ILAC, 2013) Koktekir, Bengu Ekinci; Sumer, Sua; Gedik, Sansal; Okudan, SuleymanAnthrax is an acute infection caused by Bacillus anthracis. Although it is a zoonotic disease that mainly affects herbivorous animals, it might also be contagious to humans by infected animals. The most common type is skin anthrax. When eyelid is involved; echymosis, bulla formation and necrosis can be observed. We report a 75 years old woman presenting with bilateral extensive lid echymosis and edema and diagnosed as anthrax. The clinical findings resolved with appropriate systemic and topical antibiotic treatment, and the lesions on the eyelid resulted with scatrizating ectropion. In failure of early diagnosis and treatment, there is a high risk of mortality and sequela with this particular disease which rarely involves eyelids.Öğe Assessment of capsular block syndrome with Scheimpflug camera(CANADIAN OPHTHAL SOC, 2009) Kamis, Umit; Ozturk, Banu Turgut; Sahin, Alparslan; Kerimoglu, Hurkan; Okudan, Suleyman[Abstract not Available]Öğe Association of Apolioprotein E Polymorphism with Intravitreal Ranibizumab Treatment Outcomes in Age-Related Macular Degeneration(KARGER, 2014) Bakbak, Berker; Ozturk, Banu Turgut; Zamani, Ayse Gul; Gonul, Saban; Gedik, Sansal; Yildirim, Selman; Okudan, Suleyman[Abstract not Available]Öğe Bilateral acute iris transillumination following a fumigation therapy: a village-based traditional method for the treatment of ophthalmomyiasis(TAYLOR & FRANCIS LTD, 2015) Gonul, Saban; Bozkurt, Banu; Okudan, Suleyman; Tugal-Tutkun, IlknurBilateral acute iris transillumination (BAIT) is a relatively new clinical entity characterized by bilateral acute loss of iris pigment epithelium, iris transillumination, pigment dispersion in the anterior chamber and atonic pupilla. We report herein a 50-year-old female who presented with bilateral ocular pain, severe photophobia and red eyes. One month ago, a fly hit her eye, and she instantly complained of a discomfort and sensation of a foreign body in both eyes. She used a fumigation therapy, a traditional method for the treatment of ophthalmomyiasis. During follow-up examinations, intraocular pressures increased over 40 mmHg bilaterally despite maximal medical therapy, which necessitated trabeculectomy surgery with mitomycin. This is a typical BAIT case with no antecedent fluoroquinolone use or viral disease, but a fumigation therapy. There might be a possible relationship between BAIT and traditional fumigation therapy or this association might be coincidental, both of which need further evaluation.Öğe Bilateral rhegmatogenous retinal detachment repaired with simultaneous bilateral pneumatic retinopexy(CANADIAN OPHTHAL SOC, 2009) Keimoglu, Hurkan; Ozkagnici, Ahmet; Okudan, Suleyman[Abstract not Available]Öğe Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract(TURKISH OPHTHALMOLOGICAL SOC, 2015) Bozkurt, Banu; Guzel, Huseyin; Kamis, Umit; Gedik, Sansal; Okudan, SuleymanObjectives: To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with pseudoexfoliation (PEX) syndrome and senile cataract. Materials and Methods: The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract were compared with 51 age-and gender-matched control subjects with cataract using optical low-coherence reflectometry (OLCR, Lenstar LS 900; Haag Streit AG, Switzerland) and in-vivo confocal microscopy (Confo Scan 4, Nidek Co. Ltd, Osaka, Japan). Nineteen subjects with PEX syndrome had glaucoma and were using anti -glaucoma medications. Only one eye of the subjects was used in statistical analysis and a p value less than 0.05 was considered statistically significant. Results: None of the OLCR parameters reached statistically significant differences among the 3 groups (ANOVA p>0.05). The percentage of eyes with ACD <2.5 mm was 13.7% in the control group, 24.2% in PEX eyes without glaucoma and 21.1% in PEX eyes with glaucoma, with no statistically significant differences (p=0.45). There was a significant difference in mean ECD among the 3 groups (ANOVA p=0.02), whereas no differences could be found in respect to polymegathism and pleomorphism (p>0.05). Mean ECD was significantly lower in the PEX glaucoma group (2,199.5 +/- 176.8 cells/mm(2)) than the control group (2,363 +/- 229.3 cells/mm(2)) (p = 0.02), whereas no difference was found in mean ECD of PEX eyes without glaucoma and the control group (p=0.42). ECD was less than 2,000 cells/mm(2) in 15.8% of PEX subjects with glaucoma, 9.8% of control subjects and 6.1% of PEX eyes without glaucoma, with no statistically significant difference (p=0.52). Conclusion: As eyes with both PEX glaucoma and cataract seem to be associated with decreased endothelial cell number, specular or confocal microscopy screening should be done for the patients scheduled for intraocular surgery.Öğe Comparison of Intravitreal Bevacizumab and Ranibizumab Treatment for Diabetic Macular Edema(MARY ANN LIEBERT, INC, 2011) Ozturk, Banu Turgut; Kerimoglu, Hurkan; Bozkurt, Banu; Okudan, SuleymanAim: The aim of this study was to compare the effects of bevacizumab and ranibizumab on visual function and macular thickness in patients with diabetic macular edema (DME). Methods: The data of diabetic patients who had been treated with bevacizumab for DME were reviewed. Those patients who received 1 injection of intravitreal bevacizumab and ranibizumab with at least 6-month interval were considered for enrollment. The best-corrected visual acuity (BCVA) assesment with Early Treatment Diabetic Retinopathy Study (ETDRS) chart and central subfield macular thickness (CSMT) measurement using optical coherence tomography-3 before and after the injections were recorded as outcome measures. Results: The study included 29 eyes of 29 patients with a mean age of 56.18 +/- 3.07 years. The median BCVA was 59 ETDRS letters and the median CSMT was 411 mu m preceeding the bevacizumab injection. At the 4th-6th week control after the injection, median BCVA increased to 61.50 ETDRS letters and the median CSMT decreased to 373 mu m. This change in BCVA and CSMT was found to be statistically significant (P = 0.029 and P = 0.011, respectively). The mean interval between bevacizumab and ranibizumab treatment was 9.54 +/- 2.64 months. Ranibizumab treatment increased the median BCVA from 53 to 66 ETDRS letters and decreased the median CSMT from 428 mu m to a level of 279 mu m, which were statistically significant (P < 0.001 and P < 0.001, respectively). The median change in BCVA was 4.5 ETDRS letters in the bevacizumab group and 6 ETDRS letters in the ranibizumab group (P = 0.58), whereas the median changes in CSMT were 41 and 100 mu m after bevacizumab and ranibizumab injections, respectively (P = 0.005). Conclusions: Bevacizumab and ranibizumab are both effective antivascular endothelial growth factor drugs preferred in the treatment of DME. Our comparison of both therapies on the same patients suggested that the effect on BCVA was not statistically different, but ranibizumab provided more decrease in CSMT.Öğe Corneal specular microscopy findings in Behcet's disease(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014) Ozturk, Banu Turgut; Bozkurt, Banu; Beyoglu, Abdullah; Gonul, Saban; Okudan, Suleyman[Abstract not Available]Öğe Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus(TURKISH OPHTHALMOLOGICAL SOC, 2017) Bozkurt, Banu; Yilmaz, Mevlut; Mesen, Ali; Kamis, Umit; Koktekir, Bengu Ekinci; Okudan, SuleymanObjectives: To examine changes in corneal endothelial cell density (ECD) in different stages of keratoconus and evaluate its correlation with corneal tomographic parameters. Materials and Methods: Two hundred six patients with keratoconus were enrolled in the study. Corneal topography was performed by Sirius (CSO, Italy), which has a rotating Scheimpflug camera and a Placido disc topographer. Automatic endothelial analysis was done with the non-contact endothelial microscope (20x probe) of Confoscan-4 (NIDEK, Japan). The eyes were classified into stages based on steepest keratometric value as follows: mild <45 D; moderate 45-52 D; severe >52 D and according to thinnest cornea thickness (TCT) as <400 mu m, 400-450 mu m, and >450 mu m. Tomographic and endothelial cell parameters were compared among the groups using Kruskal-Wallis test and the correlations between them were analyzed using Spearman correlation. Results: The study included 391 eyes of 100 male (24.29 +/- 7.7 years, range 11-47 years) and 106 female (26.26 +/- 7.5 years, range 13-45 years) patients (p=0.07). Mean ECD values were 2628 +/- 262 cells/mm(2), 2541.9 +/- 260.4 cells/mm(2), and 2414.6 +/- 384.3 cells/mm(2) in mild, moderate, and severe keratoconus, respectively (p<0.001) and 2592.3 +/- 277 cells/mm(2), 2502 +/- 307 cells/mm(2) and 2348 +/- 296 cells/mm(2) in corneas with TCT values >450 mu m, 400-450 mu m, and <400 mu m, respectively (p<0.001). ECD showed significant negative correlation with keratometric and elevation parameters and positive correlation with pachymetric parameters (p<0.05). Conclusion: As endothelial cell numbers seem to decrease with the progression of keratoconus, specular/confocal microscopy screening should be carried out, especially in eyes with advanced stages and corneas with TCT <400 mu m.Öğe Diurnal Variation of Anterior Chamber Flare(TURKISH OPHTHALMOLOGICAL SOC, 2015) Adam, Mehmet; Okka, Mehmet; Ozturk, Banu Turgut; Bozkurt, Banu; Kerimoglu, Hurkan; Pekel, Hamiyet; Okudan, SuleymanObjectives: To investigate the ideal time and reproducibility of anterior chamber flare measurements. Materials and Met-hods: Anterior chamber flare measurements were performed with laser flaremetre device at 8 am to 45 volunteers and these measurements were repeated on the same day at 12 pm and 4 pm. Results: Twenty- five (55.5%) of the volunteers were women and 20 (44.5%) were men; mean age was 28.67 +/- 7.40 (18- 49) years. The mean anterior chamber flare measurements taken following the ophthalmologic examination were 5.94 +/- 1.41 foton/msn at 8 am, 5.65 +/- 1.45 foton/msn at 12 pm, and 5.79 +/- 1.20 foton/msn at 4 pm. No statistical difference was found between the measurements (p=0.08). Subgroup analysis according to eye color, revealed no significant difference between flare measurements in brown, hazel, and green eyes (p=0.21). Correlation analysis demonstrated association between age and all flare measurements within the day (r=0.24, p=0.03; r=0.41, p=0.01, r=0.27, p=0.01). Conclusion: No significant diurnal change was detected in the flare measurements of our study subjects but positive correlation with age was observed. Hence, all flare measurements within a day are reliable and have high repeatability in healthy subjects.Öğe Does cataract surgery simulation correlate with real-life experience?(TURKISH OPHTHALMOLOGICAL SOC, 2018) Oflaz, Ayse Bozkurt; Koktekir, Bengu Ekinci; Okudan, SuleymanObjectives: To evaluate the correlation of cataract surgical simulator and real-life surgical experience and its contribution to surgical training. Materials and Methods: Sixteen doctors in our department were divided into three groups based on their surgical experience. After being familiarized with the device, the participants were evaluated while performing the navigation, forceps, bimanual practice, anti-tremor and capsulorhexis stages. The capsulorhexis stage was repeated five times. Participants were also assessed while performing capsulorhexis again with their non-dominant hand. The influence of repetition and surgical experience on the recorded points was evaluated. P values below 0.05 were considered statistically significant. Results: There was correlation between the participants' surgical experience and their scores in the capsulorhexis module. Their dominant hand was more successful than the non-dominant hand in capsulorhexis (p=0.004). Capsulorhexis scores increased with repetition (p=0.001). Conclusion: Results achieved with the cataract surgery simulation device correlate with surgical experience. The increase in performance upon repeated practice indicates that the simulator supports surgical training.Öğe Does lens status affect the course of early intraocular pressure and anterior chamber changes after intravitreal injection?(WILEY-BLACKWELL, 2011) Kerimoglu, Hurkan; Ozturk, Banu T.; Bozkurt, Banu; Okka, Mehmet; Okudan, SuleymanPurpose: This study aimed to observe changes in anterior chamber parameters and the course of intraocular pressure (IOP) after injection of 0.1 ml intravitreal triamcinolone acetonide (TA) and to determine differences between phakic and pseudophakic eyes without vitreous reflux. Methods: A prospective observational clinical trial was conducted with 89 patients who received an intravitreal injection of TA and did not display vitreous reflux. Intraocular pressure measurements were made before injection and at 3, 10, 20, 30 and 40 mins after injection. Pentacam measurements were made before injection and at 5, 15, 30 and 45 mins after injection. Results: Anterior chamber depth (ACD) and anterior chamber volume (ACV) were significantly greater in pseudophakic eyes than in phakic eyes at all measurement time-points (p < 0.001). There was a decrease in both ACD and ACV at 5 mins after injection, and a gradual increase to normal values was observed at 15, 30 and 45 mins after injection in all study eyes. Compared with pre-injection measurements, changes in ACD and ACV were statistically significant at each time-point in both phakic and pseudophakic eyes (p < 0.001). A significant increase in IOP within 3 mins of injection was observed in both groups and a more rapid decrease 10 mins after injection was observed in pseudophakic eyes. The differences in IOP between phakic and pseudophakic eyes at all measurement time-points, except baseline and 3 mins after injection, were statistically significant (p < 0.001). Intraocular pressure < 30 mmHg and < 24 mmHg was recorded in all pseudophakic eyes at 10 and 20 mins after intravitreal injection, respectively. Conclusions: Following intravitreal injection of 0.1 ml TA, without vitreous reflux, IOP decreased to safe levels more quickly in pseudophakic eyes than in phakic eyes. Although there were more pronounced changes in anterior chamber parameters in pseudophakic eyes, these changes were reversible without any residual clinical significance.Öğe Effect of Religious Fasting on Tear Osmolarity and Ocular Surface(LIPPINCOTT WILLIAMS & WILKINS, 2014) Koktekir, Bengu Ekinci; Bozkurt, Banu; Gonul, Saban; Gedik, Sansal; Okudan, SuleymanObjective: To evaluate the effects of religious fasting on tear secretion, tear osmolarity, corneal topography, and ocular aberrations. Methods: This prospective controlled study comprised 29 eyes of 29 healthy men. Before ophthalmologic examination, all subjects underwent corneal topography by a placido disc corneal topography and aberrometry device (OPD Scan II). Tear osmolarity was measured using OcuSense TearLab osmometer. Ocular surface disease index (OSDI) scores, tear break-up time (BUT), Schirmer I test, and lissamine green staining were evaluated. The measurements taken before and during Ramadan at the same hours between 4.00 and 5.00 PM were compared using paired sample t test, and a P value less than 0.05 was accepted as statistically significant. Results: The mean age of the study group was 27.8 +/- 5.9 years (range, 20-47 years). The mean tear osmolarity values were measured as 285.6 +/- 8.2 mOsm/L and 293.3 +/- 16.0 mOsm/L, whereas the mean Schirmer I values were 14.8 +/- 6.0 mm and 10.6 +/- 5.3 mm in nonfasting and fasting periods, respectively. Tear osmolarity, OSDI, and Oxford grading scores significantly increased (P=0.02, P=0.002, P=0.003, respectively), whereas Schirmer I values and intraocular pressure decreased (both, P<0.001) during the fasting period compared with the nonfasting period. There were no significant differences in tear BUT, keratometry values, and corneal aberration measurements between nonfasting and fasting periods (P>0.05, for all). Conclusion: Fasting significantly decreases tear production and increases tear osmolarity; however, it does not deteriorate corneal topographic parameters and ocular aberrations in healthy subjects.Öğe Evaluation of aneuploidy frequency for chromosomes 6 and 17 in eyelid tumours using the FISH technique(WILEY, 2007) Ozkagnici, Ahmet; Acar, Hasan; Zengin, Nazmi; Okudan, SuleymanAlthough basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are very common skin tumours, the incidence of chromosome aneuploidy with regard to the eyelid has not been investigated. We aimed to find the frequency of chromosome 6 and 17 aneuploidies in eyelid tumours' interphase nuclei with fluorescence in situ hybridization (I-FISH) with chromosome specific DNA probes. I-FISH with chromosome 6 and 17 centromere specific DNA probes was used in the eyelids of 10 patients with BCC or SCC and the peripheral blood cells of 10 healthy donors as controls. The frequency of chromosome 6 and 17 aneuploidies was significantly higher in 7 out of 10 patients and 5 out of 10 patients, respectively, than in controls, indicating a higher frequency of aneuploidy in BCC than in SCC of the eyelid. Distribution of hybridization signals for chromosome 6 and 17 was wide ranging, indicating heterogeneity of cell populations with aneuploidy between patients. These findings indicate that acquisition of chromosome aneuploidies in eyelid tumours may have an important pathogenic role in both BCC and SCC of the eyelid area. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.Öğe Evaluation of Choroidal Thickness in Non-arteritic Anterior Ischaemic Optic Neuropathy at the Acute and Chronic Stages(TAYLOR & FRANCIS AS, 2016) Gonul, Saban; Gedik, Sansal; Koktekir, Bengu Ekinci; Yavuzer, Kamil; Okudan, SuleymanThe objective of this study was to evaluate the measurements of choroidal thickness (CT) in patients with non-arteritic anterior ischaemic optic neuropathy (NAION) at the acute and chronic stages. This case-control study compares three groups: Group 1 included 23 eyes of 23 patients with chronic NAION, Group 2 consisted of 24 eyes of 24 patients with acute NAION, and Group 3 included 24 eyes of 24 age-matched control subjects. The average CTs for Group 1, Group 2, and Group 3 were 261.24 +/- 50.04, 280.05 +/- 74.94, and 254.74 +/- 50.11 mu m, respectively. For all measurements, no statistical significance was found between the groups (p = 0.319, 0.357, 0.680, and 0.178 for the CTs as average, foveal, superior, and inferior, respectively). Similarly, there was no difference between the CT measurements of the affected and unaffected eyes in Group 1 and Group 2 (p = 0.571, 0.741 for average, respectively). The amount of time after the onset of the disease ranged from 6.0 to 48 months (23.86 +/- 16.70 months) in Group 1 and from 1 to 30 days (7.45 +/- 8.86 days) in Group 2. There was no correlation between the CTs and follow-up times in Group 1 (p = 0.768 for average) and no association between the CTs and the thicknesses of the retinal nerve fibre layers in Group 2 (p = 0.453 for average). CT is not directly influenced by NAION at either the acute or the chronic stage of the disease. These results may also demonstrate that the changes of CT do not increase the risk of experiencing a NAION attack.Öğe Glucose regulation influences treatment outcome in ranibizumab treatment for diabetic macular edema(ELSEVIER SCIENCE INC, 2011) Ozturk, Banu Turgut; Kerimoglu, Hurkan; Adam, Mehmet; Gunduz, Kemal; Okudan, SuleymanPurpose: To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME). Methods: This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the change in best corrected visual acuity (BCVA), the central subfield macular thickness (CSMT) recorded with optical coherence tomography (OCT), and its correlation with the serum hemoglobin A(1c) values (HbA(1c)). Results: The study included 24 (36.9%) female and 41(63.1%) male patients with a mean age of 58.90 +/- 9.45 years. The mean HbA(1c) of the enrolled patients was 8.25 +/- 1.74% (range 5.7-12.7%). The median value of BCVA at baseline examination was 20/80 (52 letters), and the median CSMT was 468 pm (range 255-964 mu m). In the final control after 4-6 weeks following injection, the median value of BCVA increased to 20/50 (59.50 letters) and the median CSMT decreased to 310 pin (range 129-652 mu m). This change in BCVA and macular thickness was found to be significant (P<.001 for both). There was no correlation between BCVA and the change in macular thickness (coefficient=0.04, P=.78). The serum HbA(1c) values were found to be negatively correlated with the change in CSMT (coefficient=-0.50, P<.001). Conclusions: The results of intravitreal ranibizumab injection for DME demonstrated a beneficial effect on visual acuity and a decrease in CSMT which is inversely correlated with the serum HbA(1c), level. (C) 2011 Elsevier Inc. All rights reserved.Öğe Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography(CONSEL BRASIL OFTALMOLOGIA, 2015) Gonul, Saban; Ozturk, Banu Turgurt; Okudan, Suleyman[Abstract not Available]Öğe Metallic corneal foreign bodies: an occupational health hazard(CONSEL BRASIL OFTALMOLOGIA, 2014) Gonul, Saban; Bozkurt, Banu; Okudan, Suleyman[Abstract not Available]Öğe Posterior Corneal Steepening in Posterior Polymorphous Corneal Dystrophy(LIPPINCOTT WILLIAMS & WILKINS, 2015) Bozkurt, Banu; Ozkan, Fehmi; Yilmaz, Mevlut; Okudan, SuleymanPurpose The aim was to evaluate the anterior and posterior corneal topographic characteristics of three patients with posterior polymorphous corneal dystrophy (PPCD) using a rotating Scheimpflug camera combined with a Placido disc system (Sirius, CSO, Italy). Case Reports Two children with unilateral PPCD and a 53-year-old woman with bilateral PPCD were diagnosed by the presence of vesicles and railroad track lesions at the level of the Descemet membrane with slitlamp biomicroscopy and in vivo confocal microscopy. Anisometropic and/or meridional amblyopia was detected in both children. In the 16-year-old child, there was unilateral anterior corneal steepening with high astigmatism (plano -7.00 x170) in the eye with PPCD. The 5-year-old boy had unilateral axial myopia and against-the-rule corneal astigmatism (-12.00 -2.00 x90). Corneal topography of the woman revealed with-the-rule astigmatism and thin corneas (464 m OD and 445 m OS) in both eyes. Posterior corneal steepening greater than 25 m either in a vertical or in a horizontal pattern changing with the orientation of the railroad track band lesions was detected in all subjects. Conclusions Besides anterior corneal changes, PPCD seems to cause posterior corneal elevation, which necessitates corneal tomographic evaluation. In unilateral or highly asymmetric cases, children with PPCD should be screened for amblyopia.Öğe Postoperative fungal endophthalmitis caused by Trichosporon asahii treated with voriconazole(CONSEL BRASIL OFTALMOLOGIA, 2015) Gonul, Saban; Gedik, Sansal; Ozturk, Banu Turgut; Bakbak, Berker; Koktekir, Bengu Ekinci; Okudan, Suleyman; Dagi, Hatice TurkPostoperative fungal endophthalmitis is a rare but devastating complication of cataract surgery. Vitrectomy and intravitreal amphotericin B injection as well as administration of systemic antifungal agents have been suggested as optimal treatments for fungal endophthalmitis. However, this therapy may fail to eliminate fungal species resistant to current antifungal agents. The saprophytic fungus Trichosporon asahii is frequently observed as a cause of endogenous endophthalmitis in immunosuppressed patients. We report a case of postoperative endophthalmitis caused by T. asahii, resistant to amphotericin B. To the best of our knowledge, this is the first report of T. asahii endophthalmitis successfully treated with intravitreal and systemic voriconazole, pars plana vitrectomy, and removal of the intraocular lens and entire lens capsule.
