Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH OPHTHALMOLOGICAL SOC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: To examine changes in corneal endothelial cell density (ECD) in different stages of keratoconus and evaluate its correlation with corneal tomographic parameters. Materials and Methods: Two hundred six patients with keratoconus were enrolled in the study. Corneal topography was performed by Sirius (CSO, Italy), which has a rotating Scheimpflug camera and a Placido disc topographer. Automatic endothelial analysis was done with the non-contact endothelial microscope (20x probe) of Confoscan-4 (NIDEK, Japan). The eyes were classified into stages based on steepest keratometric value as follows: mild <45 D; moderate 45-52 D; severe >52 D and according to thinnest cornea thickness (TCT) as <400 mu m, 400-450 mu m, and >450 mu m. Tomographic and endothelial cell parameters were compared among the groups using Kruskal-Wallis test and the correlations between them were analyzed using Spearman correlation. Results: The study included 391 eyes of 100 male (24.29 +/- 7.7 years, range 11-47 years) and 106 female (26.26 +/- 7.5 years, range 13-45 years) patients (p=0.07). Mean ECD values were 2628 +/- 262 cells/mm(2), 2541.9 +/- 260.4 cells/mm(2), and 2414.6 +/- 384.3 cells/mm(2) in mild, moderate, and severe keratoconus, respectively (p<0.001) and 2592.3 +/- 277 cells/mm(2), 2502 +/- 307 cells/mm(2) and 2348 +/- 296 cells/mm(2) in corneas with TCT values >450 mu m, 400-450 mu m, and <400 mu m, respectively (p<0.001). ECD showed significant negative correlation with keratometric and elevation parameters and positive correlation with pachymetric parameters (p<0.05). Conclusion: As endothelial cell numbers seem to decrease with the progression of keratoconus, specular/confocal microscopy screening should be carried out, especially in eyes with advanced stages and corneas with TCT <400 mu m.
Açıklama
Anahtar Kelimeler
Keratoconus, cornea endothelial cell density, corneal tomography, specular microscopy, morphological changes
Kaynak
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
47
Sayı
5
