Correlation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconus

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dc.contributor.authorBozkurt, Banu
dc.contributor.authorYilmaz, Mevlut
dc.contributor.authorMesen, Ali
dc.contributor.authorKamis, Umit
dc.contributor.authorKoktekir, Bengu Ekinci
dc.contributor.authorOkudan, Suleyman
dc.date.accessioned2020-03-26T19:34:39Z
dc.date.available2020-03-26T19:34:39Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To examine changes in corneal endothelial cell density (ECD) in different stages of keratoconus and evaluate its correlation with corneal tomographic parameters. Materials and Methods: Two hundred six patients with keratoconus were enrolled in the study. Corneal topography was performed by Sirius (CSO, Italy), which has a rotating Scheimpflug camera and a Placido disc topographer. Automatic endothelial analysis was done with the non-contact endothelial microscope (20x probe) of Confoscan-4 (NIDEK, Japan). The eyes were classified into stages based on steepest keratometric value as follows: mild <45 D; moderate 45-52 D; severe >52 D and according to thinnest cornea thickness (TCT) as <400 mu m, 400-450 mu m, and >450 mu m. Tomographic and endothelial cell parameters were compared among the groups using Kruskal-Wallis test and the correlations between them were analyzed using Spearman correlation. Results: The study included 391 eyes of 100 male (24.29 +/- 7.7 years, range 11-47 years) and 106 female (26.26 +/- 7.5 years, range 13-45 years) patients (p=0.07). Mean ECD values were 2628 +/- 262 cells/mm(2), 2541.9 +/- 260.4 cells/mm(2), and 2414.6 +/- 384.3 cells/mm(2) in mild, moderate, and severe keratoconus, respectively (p<0.001) and 2592.3 +/- 277 cells/mm(2), 2502 +/- 307 cells/mm(2) and 2348 +/- 296 cells/mm(2) in corneas with TCT values >450 mu m, 400-450 mu m, and <400 mu m, respectively (p<0.001). ECD showed significant negative correlation with keratometric and elevation parameters and positive correlation with pachymetric parameters (p<0.05). Conclusion: As endothelial cell numbers seem to decrease with the progression of keratoconus, specular/confocal microscopy screening should be carried out, especially in eyes with advanced stages and corneas with TCT <400 mu m.en_US
dc.identifier.doi10.4274/tjo.22800en_US
dc.identifier.endpage260en_US
dc.identifier.issn1300-0659en_US
dc.identifier.issn2147-2661en_US
dc.identifier.issue5en_US
dc.identifier.pmid29109893en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://dx.doi.org/10.4274/tjo.22800
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34932
dc.identifier.volume47en_US
dc.identifier.wosWOS:000424255000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH OPHTHALMOLOGICAL SOCen_US
dc.relation.ispartofTURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectKeratoconusen_US
dc.subjectcornea endothelial cell densityen_US
dc.subjectcorneal tomographyen_US
dc.subjectspecular microscopyen_US
dc.subjectmorphological changesen_US
dc.titleCorrelation of Corneal Endothelial Cell Density with Corneal Tomographic Parameters in Eyes with Keratoconusen_US
dc.typeArticleen_US

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