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Öğe Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis(CAMBRIDGE UNIV PRESS, 2016) Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Oz, MehmetObjective Quercetin, one of the most potent flavonol in the family of flavonoids, has been shown to have benefits against diabetes and its complications. In the present study, we investigated effects of quercetin on depression-like behaviours and hypothalamic-pituitary-adrenal (HPA) axis in diabetic rats. Methods Experimental diabetes was induced by using streptozotocin, and either 50 or 100 mg/kg quercetin was intraperitoneally administered for 21 days. Following the last treatment, animals were subjected to the forced swim test, and subsequently, the blood was obtained by cardiac puncture to measure plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels. Results A significant increase of the total immobile time, accompanied by a decrease in the immobility latency, which suggests a depressive status, was observed in diabetic animals that was reversed by the treatment of 50 mg/kg quercetin. However, the higher dose of quercetin (100 mg/kg) was ineffective in alleviating depression-like behaviours. The plasma concentrations of ACTH, and total- and free-CORT were not affected by both doses of quercetin. Conclusion Therefore, we concluded that the antidepressant-like effects of quercetin in diabetes are independent of the HPA axis.Öğe Cytokeratin 18 and h-FABP levels in intestinal ischemia-reperfusion injury: role of coenzyme Q10(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2013) Belviranli, Muaz; Okudan, Nilsel; Gokbel, Hakki; Kiyici, Aysel; Oz, Mehmet; Kumak, AyseAim: The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemia reperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemia-reperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to laparotomy without clamping the SMA; 4) CoQ10 plus IR: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days and thereafter animals were exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period. Blood samples were taken by cardiac puncture for the analysis of serum h-FABP and M30 levels. Results: There was no difference among the groups for serum h-FABP and M30 antigen levels. Conclusion: Neither intestinal ischemia-reperfusion injury nor CoQ10 supplementation affect serum h-FABP and M30 levels in rats.Öğe The Effect of Alpha Lipoic Acid on the Hypothalamic-pituitary-adrenal Axis and Cholinergic System in an Experimental Alzheimer's Model(WILEY-BLACKWELL, 2016) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar[Abstract not Available]Öğe The Effects of Electrocautery on Peripheral Nerve: An Experimental Study(THIEME MEDICAL PUBL INC, 2016) Karalezli, Nazim; Koktekir, Ender; Yildirim, Serhat; Toy, Hatice; Oz, Mehmet; Yuceturk, AydinBackground The aim of this study was to assess the usability of an electrocautery device as nerve stimulator and to investigate histopathologically the adverse effects of electrocautery at low power on rat sciatic nerves. Methods A total of 36 female Sprague-Dawley albino rats were divided into six groups according to the power applied to their sciatic nerves (1, 2, 3, 4, 5 and 6 W, respectively). Pathologic changes were studied by microscopic examination and scored (no change = 0, mild = 1, moderate = 2, severe = 3). Multiple comparisons were provided for all groups by the Bonferroni test (one-way analysis of variance). A p value < 0.05 was accepted as statistically significant. Results The average scores were 2.66 +/- 0.51, 3.66 +/- 0.51, 5.83 +/- 1.83, 10.0 +/- 1.78, 11.0 +/- 1.54, and 13.8 +/- 0.89 in groups 1 to 6, respectively. Significant differences were found between all groups (p < 0.01), except between groups 1 and 2, groups 2 and 3, and groups 4 and 5 (p > 0.05) Variable motor responses and foot deformities were observed at the different power levels. Conclusion Although electrocautery devices provoke motor responses if getting in contact with peripheral nerves as do nerve stimulators, their use induces histopathologically adverse effects even at the lowest power. Their use around peripheral nerves should be avoided.Öğe Effects of Exercise Training and Coenzyme Q10 Supplementation on Oxidative Stress and Antioxidant Defense Markers in Heart Tissue of Aged Rats(WILEY-BLACKWELL, 2015) Okudan, Nilsel; Belviranli, Muaz; Ozdemir, Ayse; Oz, Mehmet[Abstract not Available]Öğe Effects Of Exercise Training And Coenzyme Q10 Supplementation On Pentraxin-3 And Paraoxonase Activities In Aged Rats(LIPPINCOTT WILLIAMS & WILKINS, 2013) Belviranli, Muaz; Okudan, Nilsel; Kumak, Ayse; Nurullahuglu-Atalik, Kismet Esra; Oz, Mehmet[Abstract not Available]Öğe Effects of Quercetin in IL-6 and TNF-alpha Levels in Diabetic Rats(FEDERATION AMER SOC EXP BIOL, 2015) Gergerlioglu, Hasan; Demir, Enver; Alp, Muhammed; Oz, Mehmet[Abstract not Available]
