Cytokeratin 18 and h-FABP levels in intestinal ischemia-reperfusion injury: role of coenzyme Q10

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Date

2013

Journal Title

Journal ISSN

Volume Title

Publisher

TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY

Access Rights

info:eu-repo/semantics/closedAccess

Abstract

Aim: The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemia reperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemia-reperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to laparotomy without clamping the SMA; 4) CoQ10 plus IR: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days and thereafter animals were exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period. Blood samples were taken by cardiac puncture for the analysis of serum h-FABP and M30 levels. Results: There was no difference among the groups for serum h-FABP and M30 antigen levels. Conclusion: Neither intestinal ischemia-reperfusion injury nor CoQ10 supplementation affect serum h-FABP and M30 levels in rats.

Description

Keywords

Ischemia-reperfusion injury, intestine, coenzyme Q10, M30, h-FABP

Journal or Series

TURKISH JOURNAL OF MEDICAL SCIENCES

WoS Q Value

Q3

Scopus Q Value

Q3

Volume

43

Issue

1

Citation