Cytokeratin 18 and h-FABP levels in intestinal ischemia-reperfusion injury: role of coenzyme Q10

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorGokbel, Hakki
dc.contributor.authorKiyici, Aysel
dc.contributor.authorOz, Mehmet
dc.contributor.authorKumak, Ayse
dc.date.accessioned2020-03-26T18:41:25Z
dc.date.available2020-03-26T18:41:25Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemia reperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemia-reperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to laparotomy without clamping the SMA; 4) CoQ10 plus IR: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days and thereafter animals were exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period. Blood samples were taken by cardiac puncture for the analysis of serum h-FABP and M30 levels. Results: There was no difference among the groups for serum h-FABP and M30 antigen levels. Conclusion: Neither intestinal ischemia-reperfusion injury nor CoQ10 supplementation affect serum h-FABP and M30 levels in rats.en_US
dc.identifier.doi10.3906/sag-1205-29en_US
dc.identifier.endpage11en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1205-29
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29345
dc.identifier.volume43en_US
dc.identifier.wosWOS:000321227400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectintestineen_US
dc.subjectcoenzyme Q10en_US
dc.subjectM30en_US
dc.subjecth-FABPen_US
dc.titleCytokeratin 18 and h-FABP levels in intestinal ischemia-reperfusion injury: role of coenzyme Q10en_US
dc.typeArticleen_US

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