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Öğe The Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish population(ELSEVIER, 2014) Arikoglu, Hilal; Ozdemir, Hulya; Kaya, Dudu Erkoc; Ipekci, Suleyman Hilmi; Arslan, Ahmet; Kayis, Seyit Ali; Gonen, Mustafa SaitAdiponectin, an adipose tissue specific protein encoded by the Adiponectin gene, modulates insulin sensitivity and plays an important role in regulating energy homeostasis. Many studies have shown that single nucleotide polymorphisms (SNPs) in the Adiponectin gene are associated with low plasma Adiponectin levels, insulin resistance and an increased risk of type 2 diabetes mellitus. The aim of the present study was to evaluate the contribution of the Adiponectin gene polymorphisms in genetic background of type 2 diabetes in a Turkish population. In total, 169 unrelated and non-obese diabetic patients and 119 age- and BMI-matched nondiabetic individuals with no family history of diabetes were enrolled in this study. We detected a significant association between type 2 diabetes and two SNPs: SNP - 11391G>A. which is located in the promoter region of the Adiponectin gene, and SNP + 276G > T, which is found in intron 2 of the gene (P < 0.05). The silence SNP G15G ( + 45T > G) in exon 1 and SNP + 349A > G in intron 2 also showed a weak association with type 2 diabetes (P = 0.06 and P = 0.07, respectively), while SNPs - 3971A>G in intron 1 and Y111H, R112C and H241P in exon 3 showed no association (P > 0.05). In conclusion, these findings suggest that Adiponectin gene polymorphisms might be effective on susceptibility for type 2 diabetes development which emerged from the interactions between multiple genes, variants and environmental factors. (C) 2013 Elsevier B.V. All rights reserved.Öğe ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS)+276 AND+349 IN THE ADIPONECTIN GENE WITH TYPE 2 DIABETES MELLITUS IN TURKISH POPULATION(JOHN WILEY & SONS INC, 2009) Arikoglu, Hilal; Kaya, Dudu Erkoc; Ozdemir, Hulya; Gotten, Mustafa Sait; Ipckci, Suleyman; Arslan, Ahmet; Hepdogru, Melda Aksoy[Abstract not Available]Öğe A CASE WITH ABSENCE OF B LYMPHOCYTES(SPRINGER/PLENUM PUBLISHERS, 2014) Ozdemir, Hulya; Artac, Hasibe; Ural, Onur; Karabagli, Hakan; Caliskaner, A. Zafer[Abstract not Available]Öğe The Correlation between the Level of Doxorubicin-Induced Cardiac Damage and Serum Soluble Fas in an Experimental Rat Model(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2018) Kose, Dogan; Ozdemir, Hulya; Celik, Zeliha Esin; Unlu, Ali; Artac, Hasibe; Koksal, YavuzAim: This study was planned to research the relationship between doxorubicin cardiomyopathy and the soluble Fas (sFas) level. Materials and Methods: Two groups of rats were included in the study. The control group was given physiological saline, while the study group was given doxorubicin. The rats, whose blood samples were taken weekly, were sacrificed and their myocardial tissues were removed. The tissues were examined in terms of morphological changes and surface Fas expression, while the blood samples were examined in terms of sFas level. Results: In the study group, the sFas levels at 2nd-9th weeks were higher than those found at 1st week before administrating the drug, and the increase at 2nd-7th weeks was meaningful. In addition, sFas levels were gradually increased each week during 1st-5th weeks when compared to the values of a previous week, and the increase during the first 4 weeks was meaningful. After the 5th week, the values gradually decreased each week. The mean values of the study group at 1st-8th weeks were higher than those of the control group, and the increases at 2nd-8th weeks were meaningful. The severe forms of interfibrillar hemorrhage, vascular dilatation, myocardial necrosis, inflammatory infiltration, and splitting of muscle fibers occurred with 15, 15, 17.5, 20, and 22.5 mg/kg dose of medicine, respectively. Conclusions: As the tissue injury increased, the increasing cell-surface Fas expression and sFas plasma level at the acute phase of doxorubicin-related cardiotoxicity decreased. The sFas level determined at acute phase may be helpful in predicting the existing injuries and possible late-term problems.Öğe Effects of Single Nucleotide Polymorphisms in K-ATP Channel Genes on Type 2 Diabetes in a Turkish Population(ELSEVIER SCIENCE INC, 2012) Gonen, Mustafa Sait; Arikoglu, Hilal; Kaya, Dudu Erkoc; Ozdemir, Hulya; Ipekci, Suleyman Hilmi; Arslan, Ahmet; Kayis, Seyit AliBackground and Aims. ATP-sensitive potassium (K-ATP) channels of pancreatic beta-cells play a key role in glucose-stimulated insulin secretion mechanism. The Kir6.2 protein, forming the K-ATP channel pore inwardly, and the SUR1 protein that surrounds it forming the outside part of the channel were encoded by ABCC8 and KCNJ11 genes, respectively. Recent studies reported that the single nucleotide polymorphisms (SNPs) established in these genes are associated with defects in insulin secretion and type 2 diabetes mellitus (T2DM). We aimed to investigate the allele profiles and the risk alleles of the ABCC8 and KCNJ11 genes and to highlight the associations with the disease in patients in Konya region of Turkey where T2DM is common. Methods. In this study, 169 patients with T2DM and 119 healthy controls were included. A total of 29 SNPs in ABCC8 and KCNJ11 genes were screened by PCR-SSCP technique and sequenced. Biochemical parameters and genotype-phenotype relationships were analyzed using variance analysis. Results. R1273R silent substitution in exon 31 and 16/-3t -> c substitution in noncoding region of exon 16 of ABCC8 gene showed a significant association (OR 4.8 [95% CI 2.41-9.77], p < 0.001 and OR 3.5 [95% CI 1.64-7.40], p < 0.001 under dominant and recessive models, respectively). We detected a significant association between E/K heterozygote genotype and reduced plasma insulin level in patients with T2DM (p < 0.05). Conclusions. ABCC8 exons 16 and 31 variants increase susceptibility to T2DM and KCNJ11 E23K decreases insulin secretion in a Turkish population (C) 2012 MISS. Published by Elsevier Inc.Öğe Reference ranges for serum immunoglobulin (IgG, IgA, and IgM) and IgG subclass levels in healthy children(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2019) Bayram, Rumeysa Olcay; Ozdemir, Hulya; Emsen, Ayca; Dagi, Hatice Turk; Artac, HasibeBackground/aim: The serum immunoglobulin levels are used routinely in clinical practice because they provide key information on the humoral immune status. This study aimed to determine the age-related reference values of serum immunoglobulin levels in healthy children. Materials and methods: A total of 330 healthy children, aged between 0 and 18 years, were included in this study. The serum immunoglobulin levels were measured using a nephelometric method in a total of 11 groups, each group consisting of 30 individuals, and IgG subclasses in 6 groups of children aged more than 2 years. Results: The serum IgG levels were high during the newborn period, decreased until the sixth month, and again increased to a maximum level at the age of 18 years. The level of IgA was found to be extremely low in the newborn period and then increased with age. While the lowest value was in the newborn period for serum IgM level, the highest value was in the 16- to 18-year-old period. The IgG subclasses varied depending on the age groups. Conclusion: The updated reference intervals of immunoglobulin levels in children may be used for the accurate diagnosis of immune deficiencies.Öğe Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis(TAYLOR & FRANCIS INC, 2018) Bozkurt, Banu; Artac, Hasibe; Ozdemir, Hulya; Unlu, Ali; Bozkurt, Mete Kaan; Irkec, MuratPurpose: To evaluate serum 25-hydroxyvitamin D [25(OH)D3] levels of vernal keratoconjunctivitis (VKC) children.Methods: A total of 62 non-atopic healthy children (64.5% male, mean age 10.79 3.3 years) and 29 VKC children (75.9%, mean age 12.17 2.7 years) were included in the study. Serum 25(OH)D3 levels measured by HPLC were compared between the two groups and a p value of <0.05 was considered as statistically significant.Results: The mean serum 25(OH)D3 level of VKC group was significantly lower than in the control group (11.02 +/- 5.16 ng/mL and 15.99 +/- 7.36 ng/mL, respectively) (p = 0.002). Severe vitamin D deficiency (<10 ng/mL) was detected in 48.3% of VKC children and 22.6% of the controls (p = 0.017). Time spent outdoors during daylight was higher in the control group (229.5 +/- 101.2 min) compared with the VKC group (160.7 +/- 65.9 min) (p = 0.008), and showed a significant correlation with serum 25(OH)D3 levels (Spearman rho = 0.812) (p<0.001).Conclusions: Children with VKC should be evaluated for vitamin D deficiency, which might occur secondary to sun avoidance.
