Reference ranges for serum immunoglobulin (IgG, IgA, and IgM) and IgG subclass levels in healthy children
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: The serum immunoglobulin levels are used routinely in clinical practice because they provide key information on the humoral immune status. This study aimed to determine the age-related reference values of serum immunoglobulin levels in healthy children. Materials and methods: A total of 330 healthy children, aged between 0 and 18 years, were included in this study. The serum immunoglobulin levels were measured using a nephelometric method in a total of 11 groups, each group consisting of 30 individuals, and IgG subclasses in 6 groups of children aged more than 2 years. Results: The serum IgG levels were high during the newborn period, decreased until the sixth month, and again increased to a maximum level at the age of 18 years. The level of IgA was found to be extremely low in the newborn period and then increased with age. While the lowest value was in the newborn period for serum IgM level, the highest value was in the 16- to 18-year-old period. The IgG subclasses varied depending on the age groups. Conclusion: The updated reference intervals of immunoglobulin levels in children may be used for the accurate diagnosis of immune deficiencies.
Açıklama
Anahtar Kelimeler
Healthy children, IgG subclasses, reference interval, serum immunoglobulins
Kaynak
TURKISH JOURNAL OF MEDICAL SCIENCES
WoS Q DeÄŸeri
Q4
Scopus Q DeÄŸeri
Q3
Cilt
49
Sayı
2
Künye
Bayram, R. O., Özdemir, H., Emsen, A., Türk Dağı, H., Artac, H. (2019). Reference Ranges For Serum İmmunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels İn Healthy Children. Turkish Journal Of Medical Sciences, 49,(2), 497-505.
