Reference ranges for serum immunoglobulin (IgG, IgA, and IgM) and IgG subclass levels in healthy children

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dc.contributor.authorBayram, Rumeysa Olcay
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorEmsen, Ayca
dc.contributor.authorDagi, Hatice Turk
dc.contributor.authorArtac, Hasibe
dc.date.accessioned2020-03-26T20:19:13Z
dc.date.available2020-03-26T20:19:13Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: The serum immunoglobulin levels are used routinely in clinical practice because they provide key information on the humoral immune status. This study aimed to determine the age-related reference values of serum immunoglobulin levels in healthy children. Materials and methods: A total of 330 healthy children, aged between 0 and 18 years, were included in this study. The serum immunoglobulin levels were measured using a nephelometric method in a total of 11 groups, each group consisting of 30 individuals, and IgG subclasses in 6 groups of children aged more than 2 years. Results: The serum IgG levels were high during the newborn period, decreased until the sixth month, and again increased to a maximum level at the age of 18 years. The level of IgA was found to be extremely low in the newborn period and then increased with age. While the lowest value was in the newborn period for serum IgM level, the highest value was in the 16- to 18-year-old period. The IgG subclasses varied depending on the age groups. Conclusion: The updated reference intervals of immunoglobulin levels in children may be used for the accurate diagnosis of immune deficiencies.en_US
dc.description.sponsorshipScientific Research Projects of Selcuk UniversitySelcuk University [15102034]en_US
dc.description.sponsorshipWe thank the children and their families for participating. The study was supported by the Scientific Research Projects of Selcuk University (Project No: 15102034).en_US
dc.identifier.citationBayram, R. O., Özdemir, H., Emsen, A., Türk Dağı, H., Artac, H. (2019). Reference Ranges For Serum İmmunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels İn Healthy Children. Turkish Journal Of Medical Sciences, 49,(2), 497-505.
dc.identifier.doi10.3906/sag-1807-282en_US
dc.identifier.endpage505en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue2en_US
dc.identifier.pmid30997788en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage497en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1807-282
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38153
dc.identifier.volume49en_US
dc.identifier.wosWOS:000465264700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBayram, Rumeysa Olcay
dc.institutionauthorOzdemir, Hulya
dc.institutionauthorEmsen, Ayca
dc.institutionauthorDagi, Hatice Turk
dc.institutionauthorArtac, Hasibe
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHealthy childrenen_US
dc.subjectIgG subclassesen_US
dc.subjectreference intervalen_US
dc.subjectserum immunoglobulinsen_US
dc.titleReference ranges for serum immunoglobulin (IgG, IgA, and IgM) and IgG subclass levels in healthy childrenen_US
dc.typeArticleen_US

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