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    Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma
    (JOHN LIBBEY EUROTEXT LTD, 2005) Ozdemir, M; Cengiz, SL; Gurbilek, M; Ogun, TC; Ustun, ME
    Objective. In the present study, the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels after spinal cord trauma (SCT) in rabbits were studied. Subjects. Thirty New Zeland rabbits. Interventions. The rabbits were divided equally into three groups: group I was the sham-operated group, group II suffered from SCT but received no treatment, group III was given a dose of 100 mg/kg of magnesium sulfate intravenously at 5(th) minute after SCT. Measurements. The lactate and MDA levels were measured in contused spinal cord tissue at 60 minutes after SCT. There was a significant increase of lactate and MDA levels in group II (p < 0.05) when compared with groups I and III, and a significant increase in the level of MDA in group III compared with group I, and also a significant decrease compared with group II, which was the trauma group without treatment (p < 0.05). Conclusion. The findings of this study showed that magnesium sulfate can attenuate the increase of tissue MDA and supply a normalization of lactate levels following SCT which may be related to the neuroprotective effects of (MgSO4).
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    Fibrous dysplasia - Response
    (AMER ASSOC NEUROLOGICAL SURGEONS, 2006) Arazi, M; Guney, O; Ozdemir, M; Uluoglu, O; Uzum, N
    [Abstract not Available]
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    Generalized idiopathic acanthosis nigricans treated with acitretin
    (TAYLOR & FRANCIS LTD, 2006) Ozdemir, M; Toy, H; Mevlitoglu, I; Demirkesen, C
    Generalized idiopathic acanthosis nigricans is a rare form of acanthosis nigricans. This form may be familial or nonfamilial and begins at birth or in early childhood. We report an 18-year-old boy with generalized idiopathic acanthosis nigricans who has no family history of acanthosis nigricans. The patient was treated with oral acitretin. Acitretin has been reported rarely as a therapeutic retinoid agent in the disease to date.
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    Monostotic fibrous dysplasia of the thoracic spine: clinopathological description and follow up - Case report
    (AMER ASSOC NEUROLOGICAL SURGEONS, 2004) Arazi, M; Guney, O; Ozdemir, M; Uluoglu, O; Uzum, N
    The authors report the case of a 53-year-old woman with monostotic fibrous dysplasia of the thoracic spine. The patient presented with a 1-month history of pain in the thoracic spinal region. En bloc resection of the lesion was successfully performed via a transthoracic approach, and a histopathological examination confirmed the diagnosis of fibrous dysplasia. At 24-month follow-up examination, pain and vertebral instability were absent. The findings in this case illustrate that, although very rare, monostotic fibrous dysplasia of the thoracic spine should be considered in the differential diagnosis of spinal tumors. Although a consensus for management of this disease has not been achieved, the authors recommend radical removal of all involved bone as well as internal fixation or bone graft-assisted fusion to achieve long-term stabilization.
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    Primary echinococcus infestation of the bone and muscles
    (LIPPINCOTT WILLIAMS & WILKINS, 2005) Arazi, M; Erikoglu, M; Odev, K; Memik, R; Ozdemir, M
    Hydatid diseases of the bone and muscles are rare, generally are incurable, and have a high level of recurrence. We attempted to ascertain whether the recurrence rate decreased in patients with hydatid disease infestation of the bone and skeletal muscle who were treated with current surgical techniques and antihelminthic chemotherapy, and whether the outcomes for bone infestation were different when compared with outcomes for muscular infestation. We retrospectively reviewed 15 patients with hydatid disease of the bone (eight patients) and muscle (seven patients). The average followup was 30 months (range, 6-69 months). Recurrence was observed in four patients with bone involvement. No patient with muscle involvement had a recurrence after excision. Hydatid disease of the bone often is recurrent and progressive despite using advanced diagnostic studies, improved surgical techniques, and newly developed antihelminthic drugs. The disease status also was not as good as for patients with bone lesions when compared with patients with muscular lesions.