Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
JOHN LIBBEY EUROTEXT LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective. In the present study, the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels after spinal cord trauma (SCT) in rabbits were studied. Subjects. Thirty New Zeland rabbits. Interventions. The rabbits were divided equally into three groups: group I was the sham-operated group, group II suffered from SCT but received no treatment, group III was given a dose of 100 mg/kg of magnesium sulfate intravenously at 5(th) minute after SCT. Measurements. The lactate and MDA levels were measured in contused spinal cord tissue at 60 minutes after SCT. There was a significant increase of lactate and MDA levels in group II (p < 0.05) when compared with groups I and III, and a significant increase in the level of MDA in group III compared with group I, and also a significant decrease compared with group II, which was the trauma group without treatment (p < 0.05). Conclusion. The findings of this study showed that magnesium sulfate can attenuate the increase of tissue MDA and supply a normalization of lactate levels following SCT which may be related to the neuroprotective effects of (MgSO4).
Açıklama
Anahtar Kelimeler
lactate, lipid peroxidation, magnesium sulfate, malondialdehyde, spinal cord trauma
Kaynak
MAGNESIUM RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
18
Sayı
3
