Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma

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dc.contributor.authorOzdemir, M
dc.contributor.authorCengiz, SL
dc.contributor.authorGurbilek, M
dc.contributor.authorOgun, TC
dc.contributor.authorUstun, ME
dc.date.accessioned2020-03-26T16:57:03Z
dc.date.available2020-03-26T16:57:03Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective. In the present study, the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels after spinal cord trauma (SCT) in rabbits were studied. Subjects. Thirty New Zeland rabbits. Interventions. The rabbits were divided equally into three groups: group I was the sham-operated group, group II suffered from SCT but received no treatment, group III was given a dose of 100 mg/kg of magnesium sulfate intravenously at 5(th) minute after SCT. Measurements. The lactate and MDA levels were measured in contused spinal cord tissue at 60 minutes after SCT. There was a significant increase of lactate and MDA levels in group II (p < 0.05) when compared with groups I and III, and a significant increase in the level of MDA in group III compared with group I, and also a significant decrease compared with group II, which was the trauma group without treatment (p < 0.05). Conclusion. The findings of this study showed that magnesium sulfate can attenuate the increase of tissue MDA and supply a normalization of lactate levels following SCT which may be related to the neuroprotective effects of (MgSO4).en_US
dc.identifier.endpage174en_US
dc.identifier.issn0953-1424en_US
dc.identifier.issn1952-4021en_US
dc.identifier.issue3en_US
dc.identifier.pmid16259377en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19708
dc.identifier.volume18en_US
dc.identifier.wosWOS:000232475700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJOHN LIBBEY EUROTEXT LTDen_US
dc.relation.ispartofMAGNESIUM RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectlactateen_US
dc.subjectlipid peroxidationen_US
dc.subjectmagnesium sulfateen_US
dc.subjectmalondialdehydeen_US
dc.subjectspinal cord traumaen_US
dc.titleEffects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord traumaen_US
dc.typeArticleen_US

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