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Öğe Acitretin narrow-band TL-01 phototherapy but not etanercept treatment improves a localized inflammatory linear verrucous epidermal naevus with concomitant psoriasis(WILEY, 2009) Ozdemir, M.; Mevlitoglu, I.; Balevi, A.[Abstract not Available]Öğe Assessment of ischaemia-modified albumin level in patients with psoriasis(WILEY-BLACKWELL, 2012) Ozdemir, M.; Kiyici, A.; Balevi, A.; Mevlitoglu, I.; Peru, C.Background. Ischaemia-modified albumin (IMA) is increased in diseases associated with oxidative stress, as detected using the albumin cobalt-binding test. Oxidative stress plays an important role in the development of psoriasis. Aim. To investigate circulating IMA levels in patients with psoriasis and its association with the disease characteristics. Methods. Serum IMA and albumin concentrations were evaluated in 26 patients with psoriasis and 26 healthy controls matched for age, gender and body mass index. Levels of albumin, IMA and adjusted IMA were compared between the groups. Results. IMA and adjusted IMA were significantly higher in patients with psoriasis [0.55 +/- 0.04 and 0.54 +/- 0.05 absorbance units (ABSU), respectively] than in healthy controls (0.38 +/- 0.04 and 0.38 +/- 0.05 ABSU, respectively). The two groups had similar albumin levels, but there was a negative correlation between IMA and albumin levels in patients with psoriasis. IMA did not correlate with any disease characteristics. Conclusions. IMA levels are higher in patients with psoriasis than in healthy controls. IMA might be produced through an adaptive response to chronic hypoxia and oxidative stress, which might play a role in the systemic inflammation seen in psoriasis.Öğe C-14 Urease breath test in dyspeptic patients: Comparison wiht other methods(SPRINGER, 2005) Ozdemir, M.; Serdengecti, M.; Ayan, A.; Baykan, M.[Abstract not Available]Öğe Comparative evaluation of indirect immunofluorescence assay and ELISA methods for the diagnosis of Epstein-Barr virus infection(ELSEVIER SCIENCE BV, 2009) Feyzioglu, B.; Ozdemir, M.; Baykan, M.[Abstract not Available]Öğe Comparison of the Detection of Influenza A and B Viruses by Different Methods(SAGE PUBLICATIONS LTD, 2012) Ozdemir, M.; Yavru, S.; Baysal, B.OBJECTIVE: To investigate the detection of influenza viruses by three different methods. METHODS: Nasopharyngeal swabs were collected from patients with influenza symptoms and examined for influenza A and B viruses using a rapid antigen test, a multiplex polymerase chain reaction (PCR) test and a shell vial cell culture test. RESULTS: Using the shell vial cell culture test, the rapid antigen test and the multiplex PCR test in 130 patients, 31 (23.8%), 24 (18.5%) and 24 (18.5%) samples, respectively, were positive for influenza A and 10 (7.7%), nine (6.9%) and four (3.1%) samples, respectively, were positive for CHAIN REACTION TEST; influenza B. Compared with the shell vial test, the sensitivity, specificity, and positive and negative predictive values of the rapid antigen test were 77.4%, 93.3%, 80.0% and 93.1%, respectively, for influenza A, and 90.0%, 95.8%, 64.2% and 99.1%, respectively, for influenza B. The corresponding values for the multiplex PCR test were 77.4%, 95.9%, 85.7% and 93.1%, respectively, for influenza A, and 40.0%, 97.5%, 57.1% and 95.1%, respectively, for influenza B. CONCLUSIONS: The multiplex PCR test and the rapid antigen test are both effective in the detection of influenza A and B viruses.Öğe The effect of transcutaneous electrical nerve stimulation in the treatment of lichen simplex: a prospective study(WILEY-BLACKWELL PUBLISHING, INC, 2009) Engin, B.; Tufekci, O.; Yazici, A.; Ozdemir, M.Transcutaneous electrical nerve stimulation (TENS) has recently emerged as a possible effective treatment for pruritic dermatoses. Lichen simplex (LS) is one such condition, which may persist despite intensive topical treatments. To investigate the efficacy of TENS treatment in relieving pruritus in lichen simplex. In total, 22 patients with LS unresponsive to topical corticosteroids underwent TENS treatment. The patients rated the pruritus intensity on a visual analogue scale (VAS). The mean reduction in VAS score from baseline to the end of 4 weeks treatment was 4.50 (95% CI 3.65-5.34) for all patients. The difference between the baseline and at the end of the study was significant (P < 0.01). By the end of the study, 18 (80%) of the subjects experienced a reduction in pruritus intensity of > 50%. From our clinical observation, we suggest that TENS may prove to be a useful and well-tolerated treatment modality for the treatment of pruritus in patients with LS.Öğe En coup de sabre accompanied by pachydermoperiostosis: a case report(CLINICAL & EXPER RHEUMATOLOGY, 2007) Ozdemir, M.; Yildirim, S.; Mevlitoglu, I.Scleroderma en coup de sabre, a variant of localized scleroderma is a disorder characterized by fibrosis of connective tissue. We report a 21-year-old female with scleroderma en coup de sabre accompanied by pachydermoperiostosis. She was born to consanguineous parents and her older siser also had pachydermoperiostosis characterized by clubbing of the digits, enlargement of distal parts of the extremities. The two disorders were diagnosed by clinical examination, histological and x-ray findings. In contrast to scleroderma, pachydermoperiostosis is a hypertrophic process characterized by periosteal proliferation of the tubuler bones and hypertrophic skin changes. We discuss this interesting coexistence and review the literature.Öğe Evaluation and Comparison of Three Different Anti-hepatitis C Virus Antibody Tests based on Chemiluminescence and Enzyme-linked Immunosorbent Assay Methods used in the Diagnosis of Hepatitis C Infections in Turkey(SAGE PUBLICATIONS LTD, 2009) Kesli, R.; Ozdemir, M.; Kurtoglu, M. G.; Baykan, M.; Baysal, B.The routine diagnosis of hepatitis C virus (HCV) infection is based on the detection of anti-HCV antibodies by two main methods (enzyme immunoassay [EIA] and chemiluminescence immunoassay [CIA]) but false-positives are a problem. We investigated three anti-HCV tests: two CIAs (Cobas (R) e 601 and Architects i2000SR); and one EIA (Ortho (R) HCV 3.0). Two other anti-HCV tests were also performed as supplementary and confirmatory tests, respectively: a recombinant strip immunoblot assay (RIBA HCV 3.0 SIA) and a reverse transcriptase polymerase chain reaction-based assay for HCV-RNA. After discriminating the false-positive results, the true anti-HCV seropositivity rate in 7156 serum samples was 0.91%. The seropositivity and false-positive rates for the Cobas (R) e 601, Architects i2000SR and Ortho (R) HCV 3.0 anti-HCV tests were 1.9% and 0.99%, 1.2% and 0.29%, and 0.87% and 0.01%, respectively. The mean level of HCV-RNA was 3399 x 10(3) IU/ml. Critical levels for false-positivity for HCV-RNA were a cut-off index of 200 for Cobas (R) e 601, a signal/cut-off (S/CO) of 5 for Architects i2000SR and an S/CO of 1.2 for Ortho (R) HCV 3.0. Positive and negative results for the RIBA HCV 3.0 SIA assay all accorded with the HCV-RNA assay, except for 23 (17%) 'indeterminate' results, all of which were negative with the HCV-RNA assay. In conclusion, to eliminate doubts related to false-positive findings in the initial HCV screening tests, additional confirmatory HCV-RNA assay should be performed.Öğe Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study(WILEY, 2011) Gumusel, M.; Ozdemir, M.; Mevlitoglu, I.; Bodur, S.Background Treatment of psoriatic nail is difficult. Objective The aim of this study was to evaluate and compare the efficacy and safety of methotrexate and cyclosporine in psoriatic nail. Methods Thirty-seven psoriatic patients with nail involvement were randomized to treatment with methotrexate (initial dose, 15 mg per week) or cyclosporine (initial dose, 5 mg per kg of bodyweight per day) for 24 weeks. The primary outcome was the Nail Psoriasis Severity Index (NAPSI). The Psoriasis Area and Severity Index (PASI), doctor and patient global score were also measured. The scores were determined by a blinded observer. Results Seventeen patients completed the study in each group. The mean percentages of reduction of the NAPSI score after methotrexate and cyclosporine treatments were 43.3% and 37.2%, respectively. No significant differences between the treatment groups was found for in the NAPSI, PASI, physician's and patient's global score at the end of the study period. The methotrexate group showed a significant improvement in nail matrix scores and the cyclosporine group in nail bed score. Conclusion Moderate effectiveness on psoriatic nail was found in the two treatment agents and there were no significant differences in efficacy between the groups. A significant improvement was detected in methotrexate group for the nail matrix findings, and in cyclosporine group for the nail bed findings.Öğe Narrow-band ultraviolet B phototherapy for the treatment of vitiligo: evidence against an autoimmune pathogenesis(WILEY-BLACKWELL, 2008) Engin, B.; Baysal, I.; Reisli, I.; Ozdemir, M.; Toy, H.[Abstract not Available]Öğe Patch test results in patients with progressive pigmented purpuric dermatosis(WILEY-BLACKWELL PUBLISHING, INC, 2009) Engin, B.; Ozdemir, M.; Kaplan, M.; Mevlitoglu, I.[Abstract not Available]Öğe Pathergy reaction in different body areas in Behcet's disease(BLACKWELL PUBLISHING, 2007) Ozdemir, M.; Balevi, S.; Deniz, F.; Mevlitoglu, I.Behcet's disease (BD) is a chronic inflammatory multisystemic disorder characterized mainly by vasculitis. Although the pathergy reaction (PR) has been accepted as one of the major criteria in this disease, there is a lack of a standardized method to measure PR. The aim of this study was to evaluate results of PR in different body areas and the effect on the positive rate of PR of application of numerous needle pricks. The pathergy test was performed using simultaneous 16 needle pricks with 20G disposable needles on different body areas of 56 patients with BD, 49 patients with recurrent aphthous stomatitis (RAS) and 17 healthy subjects. No positive PR was found in healthy controls, but was observed in nine patients with RAS (18.3%). It was detected in 48 of 56 patients with BD, a positive rate of 85.7%. The site most frequently positive for PR was the forearm, while the least frequent was the abdomen. Multiple needle pricks could play an important role in increasing the positive rate of PR in BD, and it may be important in the investigation of aetiological factors in RAS.Öğe Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria(WILEY-BLACKWELL PUBLISHING, INC, 2008) Engin, B.; Ozdemir, M.Background Treatment of chronic idiopathic urticaria (CIU) is difficult. Objective The purpose of this study was to evaluate the efficacy and safety of dapsone in CIU. Methods The response to dapsone was evaluated in 65 CIU patients with a randomized, two armed study: 3-month dapsone + desloratadin and 3-month desloratadin. All were followed for up to 3 months and 3 months after; all took desloratadine 10 mg daily throughout the study. The primary measure of efficacy was a daily urticaria activity score (UAS) of weal numbers and itch (maximum score, 42 per week). Results Sixty-five patients completed the randomized 3-month trial medication. Mean reduction in UAS from baseline at 3 months was 7 [95% confidence interval (95% CI), 6.92-7.08] for active group and 5.77 (95% CI, 5.47-6.08) for control subjects (P < 0.001). The reduction in visual analogue score (VAS) at 3 months for active group (mean, 2.58; 95% CI, 2.33-2.83) and control subjects (mean, 2.55; 95% CI, 2.38-2.73) was also significant (P < 0.001). The reduction of UAS and VAS at 3 months compared between active group and control subjects showed no significant difference. Mean reduction in UAS from the end of the study at 3 months after was 1.16 and -4.8 for active and control subjects, respectively. These results were compared with each other, and it was statistically significant (P <= 0.05). Limitations No placebo was used. The study was not blinded. Lack of blinding may have led to bias. The follow-up period was short. Conclusion This study shows that dapsone leads to a persistent decrease in VAS and UAS and is associated with complete remission in some patients.
