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    The effects of zinc deficiency and testosterone supplementation on leptin levels in castrated rats and their relation with LH, FSH and testosterone
    (MAGHIRA & MAAS PUBLICATIONS, 2005) Ozturk, A; Baltaci, AK; Mogulkoc, R; Oztekin, E; Kul, A
    AIM: The aim of this study was to investigate how zinc-deficiency and testosterone supplementation, both in combination and individually, affect plasma LH, FSH and leptin levels in castrated rats. DESIGN: Group 1, Control Group. Group 2, Castration Group. Group 3, Testosterone Group. Group 4, Zinc-deficient Group. Group 5, Testosterone, Zinc-deficient Group. Group 6, Zinc-deficient, Castration Group. Group 7, Testosterone, Castration Group. Group 8, Zinc-deficient, Testosterone, Castration Group. MEASUREMENTS: Plasma zinc, leptin, LH, FSH, free and total testosterone levels were measured. RESULTS: Group 2 had the highest levels of leptin and LH, besides having the highest FSH levels together with Group 6 (p < 0.01). Groups 5 and 8 had the lowest leptin levels (p < 0.01). Leptin levels in Groups 4 and 7 were higher than those in Groups 5 and 8, but lower than those in all other groups (p < 0.01). LH levels in Group 4 were not different than those in Groups 3, 5 and 8, but significantly lower than those in all other groups (p < 0.01). Free and total testosterone levels were higher in Group 4 than in castration groups that were not supplemented testosterone, but were lower in the former than in all others (p < 0.01). CONCLUSION: Plasma LH may be more effective than testosterone on plasma leptin and zinc can be an important mediator of the effect LH exercises on leptin.
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    A new approach in the management of the hydrocele with a silicone catheter
    (ELSEVIER SCIENCE INC, 2004) Arslan, M; Kilinc, M; Yilmaz, K; Ozturk, A
    Introduction. To describe a new alternative technique to overcome several disadvantages of previous techniques to repair idiopathic hydrocele. Idiopathic hydrocele, which causes scrotal enlargement and discomfort for patients, is an abnormal fluid collection between the parietal and visceral layers of tunica vaginalis of the testis. Surgical and sclerotherapy treatments have previously been used to treat this problem. Technical Considerations. Forty-five patients with hydrocele (aged 19 to 67 years) underwent an alternative procedure using a silicone catheter 15 to 20 cm in length in which holes had been made to enable flow of the hydrocele fluid from the parietal layer of the tunica vaginalis to the surrounding scrotal tissue. After an incision of approximately 5 mm on the scrotal wall with a scalpel knife, a cannula was pushed through the hydrocele sac with a gentle rotation until reaching the upper scrotal wall. A-silicone catheter with holes was passed through the cannula to the point of the incision by way of the cannula. At the end, both tips of the catheter were sutured. During the procedure, the hydrocele fluid was emptied using an angiocatheter before the cannula was removed. Conclusions. The results of this study indicate that this procedure does not require dissection, incision, or manipulation of the scrotal contents during treatment. It also resulted in a low rate of recurrence during the 1 to 3 years of follow-up. Additionally, the procedure has minimal complications and requires a short time, only about 15 minutes. (C) 2004 Elsevier Inc.
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    Short-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidism
    (AKADEMIAI KIADO, 2005) Mogulkoc, R; Baltaci, AK; Oztekin, E; Ozturk, A; Sivrikaya, A
    Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.
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    Superoxide dismutase and glutathione peroxidase enzyme activities in larynx carcinoma
    (TAYLOR & FRANCIS AS, 2005) Kalayci, A; Ozturk, A; Ozturk, K; Karagozoglu, E; Dolanmaz, D
    Conclusions. It can be concluded that these changes are related to damage at the DNA level or to the inhibitory effects of tumor promoters. Increases in GSH-Px activities may be related to the independence of this enzyme from the suppressive effects of tumor promoters. This study and others in the literature show that it is not possible to generalize the activities of SOD and GSH-Px in cancer. Objective. There has been growing interest in the role of free radicals as a cause of cancer. It has been suggested that an increase in activated forms of oxygen in cells due to overproduction and/or the inability to destroy them may lead to severe damage of cell structures. As a result of these changes, some chromosomal aberrations and carcinogenesis may develop. Superoxide dismutase ( SOD) and glutathione peroxidase (GSH-Px) are two important antioxidant enzymes involved in enzymatic antioxidant defense mechanisms. To our knowledge there have been no previous studies in the literature investigating the activities of SOD and GSH-Px in laryngeal cancer. Material and methods. The study subjects comprised 10 male patients (age range 43-76 years) with laryngeal carcinoma and 10 healthy controls ( 4 males, 6 females; age range 40-69 years) with intraoral hyperplastic fibrous tissue. Homogenate SOD and GSH-Px activities were measured using commercially available kits. Results. GSH-Px levels were significantly increased in the cancerous tissues compared with cancer-free adjacent tissues and fibrous hyperplasia tissues (p < 0.05), whereas there was no significant difference between SOD activities (p > 0.05). There was also no significant difference between GSH-Px activity in cancer-free adjacent tissues and fibrous hyperplasia tissues (p > 0.05).
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    Testosterone and zinc supplementation in castrated rats: Effects on plasma leptin levels and relation with LH, FSH and testosterone
    (PERGAMON-ELSEVIER SCIENCE LTD, 2006) Baltaci, AK; Mogulkoc, R; Ozturk, A
    The present study aims to examine how zinc and testosterone supplementation, in combination and separately, affect plasma LH, FSH and leptin levels in castrated rats. Eighty experimental animals used in the study were allocated to 8 groups, each containing an equal number of rats. Group 1, control group; Group 2, castration group; Group 3, testosterone group (5 mg/kg/day); Group 4, zinc-supplemented group (3 mg/kg/ day); Group 5, testosterone and zinc-supplemented group; Group 6, zinc-supplemented castration group; Group 7, testosterone and castration group; and Group 8, zinc-supplemented, testosterone and castration group. Plasma zinc, leptin, LH, FSH and free and total testosterone levels were determined in the blood samples collected from the animals by decapitation. Group 2 had the highest leptin levels and together with group 6, it also showed the highest LH and FSH levels (p < 0.01). The lowest leptin levels were observed in groups 3 and 7 (p < 0.01). Leptin levels in groups 4 and 6 were higher than those in ups 1, 5 and 8 (p < 0.01). LH levels gro in group 4 were lower than those in groups 2 and 6 and higher than those in all other groups (p < 0.01). Free and total testosterone levels in groups 7 and 8 were lower than those in groups 3 and 5, but higher than those in all other groups (p < 0.01). Plasma LH levels may be more effective than testosterone on plasma leptin and zinc may be an important mediator of the effect LH has on leptin. (c) 2005 Elsevier Inc. All rights reserved.