Testosterone and zinc supplementation in castrated rats: Effects on plasma leptin levels and relation with LH, FSH and testosterone
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The present study aims to examine how zinc and testosterone supplementation, in combination and separately, affect plasma LH, FSH and leptin levels in castrated rats. Eighty experimental animals used in the study were allocated to 8 groups, each containing an equal number of rats. Group 1, control group; Group 2, castration group; Group 3, testosterone group (5 mg/kg/day); Group 4, zinc-supplemented group (3 mg/kg/ day); Group 5, testosterone and zinc-supplemented group; Group 6, zinc-supplemented castration group; Group 7, testosterone and castration group; and Group 8, zinc-supplemented, testosterone and castration group. Plasma zinc, leptin, LH, FSH and free and total testosterone levels were determined in the blood samples collected from the animals by decapitation. Group 2 had the highest leptin levels and together with group 6, it also showed the highest LH and FSH levels (p < 0.01). The lowest leptin levels were observed in groups 3 and 7 (p < 0.01). Leptin levels in groups 4 and 6 were higher than those in ups 1, 5 and 8 (p < 0.01). LH levels gro in group 4 were lower than those in groups 2 and 6 and higher than those in all other groups (p < 0.01). Free and total testosterone levels in groups 7 and 8 were lower than those in groups 3 and 5, but higher than those in all other groups (p < 0.01). Plasma LH levels may be more effective than testosterone on plasma leptin and zinc may be an important mediator of the effect LH has on leptin. (c) 2005 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
castration, testosterone and zinc supplementation, leptin, LH, FSH, testosterone
Kaynak
LIFE SCIENCES
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
78
Sayı
7
