Testosterone and zinc supplementation in castrated rats: Effects on plasma leptin levels and relation with LH, FSH and testosterone

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dc.contributor.authorBaltaci, AK
dc.contributor.authorMogulkoc, R
dc.contributor.authorOzturk, A
dc.date.accessioned2020-03-26T17:04:27Z
dc.date.available2020-03-26T17:04:27Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study aims to examine how zinc and testosterone supplementation, in combination and separately, affect plasma LH, FSH and leptin levels in castrated rats. Eighty experimental animals used in the study were allocated to 8 groups, each containing an equal number of rats. Group 1, control group; Group 2, castration group; Group 3, testosterone group (5 mg/kg/day); Group 4, zinc-supplemented group (3 mg/kg/ day); Group 5, testosterone and zinc-supplemented group; Group 6, zinc-supplemented castration group; Group 7, testosterone and castration group; and Group 8, zinc-supplemented, testosterone and castration group. Plasma zinc, leptin, LH, FSH and free and total testosterone levels were determined in the blood samples collected from the animals by decapitation. Group 2 had the highest leptin levels and together with group 6, it also showed the highest LH and FSH levels (p < 0.01). The lowest leptin levels were observed in groups 3 and 7 (p < 0.01). Leptin levels in groups 4 and 6 were higher than those in ups 1, 5 and 8 (p < 0.01). LH levels gro in group 4 were lower than those in groups 2 and 6 and higher than those in all other groups (p < 0.01). Free and total testosterone levels in groups 7 and 8 were lower than those in groups 3 and 5, but higher than those in all other groups (p < 0.01). Plasma LH levels may be more effective than testosterone on plasma leptin and zinc may be an important mediator of the effect LH has on leptin. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.lfs.2005.05.098en_US
dc.identifier.endpage752en_US
dc.identifier.issn0024-3205en_US
dc.identifier.issue7en_US
dc.identifier.pmid16150461en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage746en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.lfs.2005.05.098
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20706
dc.identifier.volume78en_US
dc.identifier.wosWOS:000234700700012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofLIFE SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcastrationen_US
dc.subjecttestosterone and zinc supplementationen_US
dc.subjectleptinen_US
dc.subjectLHen_US
dc.subjectFSHen_US
dc.subjecttestosteroneen_US
dc.titleTestosterone and zinc supplementation in castrated rats: Effects on plasma leptin levels and relation with LH, FSH and testosteroneen_US
dc.typeArticleen_US

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