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  • Küçük Resim Yok
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    Pyometranın nadir nedeni: Apendiksin Karsinoid Tümörü
    (2016) Yılmaz, Setenay Arzu; Acar, Fahrettin; Kerimoğlu, Özlem Seçilmiş; Pekin, Aybike Tazegül; İncesu, Feyza; Çelik, Çetin
    Piyometra uterin kavite içerisinde enfekte pürülan materyalin birikmesidir ve uterusun doğal drenajının bozulduğu durumlarda görülmektedir. En yaygın nedeni jinekolojik kanserlerdir. Apendiksin karsinoid tümörlerinde teşhis genellikle genç hastalarda akut apandisit tanısı ile yapılan apendektomilerde konulur. Biz bu olguda tuba uterinaya fistülize apendiksin karsinoid tümörü sonucu gelişen piyometra olgusunu sunmayı amaçladık
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    Relations of serum visfatin and resistin levels with endometrial cancer and factors associated with its prognosis
    (Asian Pacific Organization for Cancer Prevention, 2015) İlhan, Tolgay Tuyan; Kebapcılar, Ayşe Gül; Yılmaz, Setenay Arzu; İlhan, Türkan; Kerimoğlu, Özlem Seçilmiş; Pekin, Aybike Tazegül; Akyürek, Fikret; Ünlü, Ali; Çelik, Çetin
    Background: The aims of this study were compare the serum visfatin and resistin levels between endometrial cancer (EC) patients and controls and evaluate their power to predict prognosis. Materials and Methods: This prospective study was conducted between March 2013 to June 2014 on the Gynecologic Oncology Department of the University of Selcuk, Konya, Turkey. A total of 42 EC patients and 42 controls were included and assessed for differences in serum visfatin and resistin levels, along with prognostic factors. Results: Endometrial cancer patients had significantly higher visfatin levels than control s (p: 0.011), associated with deep myometrial invasion (p: 0.019). In contrast the serum level of resistin did not significantly differ between EC patients and controls (p: 0.362). However, high resistin level in EC patients was associated with increase lymph node metastasis (p: 0.009). On logistic regression analysis, we found that serum visfatin elevation was associated with risk of myometrial invasion (OR: 1,091; 95%CI: 1.021- 1.166; p: 0.010) and serum resistin with risk of lymph node metastasis (OR: 1.018; 95%CI: 1.000- 1.035; p: 0.046). For myometrial invasion prediction, a serum visfatin level greater than 26.8 ng/mL demonstrated a sensitivity and specificity of 66.6 % and 96.4%, respectively. For lymph node metastasis prediction, the best cut-off for serum resistin level was 599ng/mL. A serum resistin level greater than this demonstrated a sensitivity and specificity of 87.5% and 77.1%, respectively. Conclusions: Our data suggest that serum visfatin is elevated in patients with EC and serum visfatin and resistin levels could be used to predict the risk of advance stage lesions.
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    The relationship between Polycystic ovary syndrome and vitamin D levels
    (GALENOS YAYINCILIK, 2015) Yılmaz, Setenay Arzu; Altınkaya, Sündüz Özlem; Kebabcılar, Ayşe Gül; Kerimoğlu, Özlem Seçilmiş; Pekin, Aybike Tazegül; Abuşoğlu, Sedat; Çelik, Çetin
    Objective: The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS). Materials and Methods: Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m(2)) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m(2)) women with PCOS and 56 normal-weight controls participated in the study. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9: 00 am after an overnight fast. Circulating concentrations of 25-OH D, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, TSH, free testosterone, dehydroepiandrosterone sulphate (DHEA-SO4), 17-hydroxyprogesterone, sex hormone-binding globulin (SHBG), fasting insulin, fasting glucose, and lipid profile were assessed. Results: Normal weight (BMI 19-24.99 kg/m(2)) and overweight (BMI 25-29.99 kg/m(2)) women with PCOS were compared with normal-weight controls and lower 25-OH D levels were found in both PCOS groups (p<0.05 and p<0.01, respectively 25-OH D significantly negatively correlated with waist circumference (WC), waist-to-hip ratio (WHR), free testosterone and modified Ferriman-Gallwey scores, however, there was a positive correlation between 25-OH D and SHBG levels (p<0.05). Conclusion: Our findings suggest that PCOS is associated with hypovitaminosis
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    The role of human epididymis secretory protein E4 in patients with endometrial cancer and premalignant endometrial lesions
    (TAYLOR & FRANCIS INC, 2017) Yılmaz, Setenay Arzu; Altınkaya, Sündüz Özlem; Kerimoğlu, Özlem Seçilmiş; Pekin, Aybike Tazegül; Akyürek, Fikret; İlhan, Tolgay Tuyan; Benzer, Nilgün
    We evaluated the concentrations of human epididymis secretory protein E4 (HE4) and Ca-125 in relation to clinicopathologic features in patients with endometrial cancer and premalignant endometrial lesions. Women with abnormal uterine bleeding (n=167) who underwent endometrial sampling were divided into four groups. Group 1: endometrial cancer (n=68), group 2: atypical endometrial hyperplasia (n=12), group 3: endometrial hyperplasia without atypia (n=39) and group 4: controls (n=48). Women with endometrial cancer exhibited higher concentrations of HE4 levels than controls (91.4pmol/L vs. 46.2pmol/L, p<0.001). HE4 levels were significantly higher in patients with lymphatic involvement, deep myometrial invasion, lymphovascular space involvement and non-endometrioid histology (p<0.001). The sensitivity, specificity, positive and negative predictive values for HE4 in detecting endometrial cancer were 72.7%, 84.4%, 80% and 78.4%, respectively. Preoperative HE4 levels are more elevated in women with endometrial cancer than those with benign endometrium as well as in women with prognostic high-risk factors with endometrial cancer. HE4 may be used as an additional marker in combination with other clinicopathologic features for planning the treatment.
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    Serum Levels of Neopterin In Gestational Diabetes Mellitus: The Relationship With Apgar Scores
    (SPRINGER HEIDELBERG, 2015) İpekci, Süleyman Hilmi; Kebapcılar, Ayşe Gül; Yılmaz, Setenay Arzu; İlhan, Tolgay Tuyan; Pekin, Aybike Tazegül; Abuşoğlu, Sedat; Ünlü, Ali; Çelik, Çetin; Annagur, Ali
    Purpose This study was designed to evaluate neopterin levels and low Apgar scores in pregnancies with gestational diabetes mellitus (GDM) vs. normal control pregnancies. Methods We carried out a cross-sectional study by enrolling 81 pregnant women with GDM and 38 pregnant women without GDM. Results Maternal and cord blood neopterin levels were higher in women with GDM. There was a significant positive association between fasting blood glucose levels and maternal serum neopterin levels. The results of 50-g oral glucose challenge tests revealed a correlation between maternal and cord neopterin levels. Pregnancies complicated by GDM exhibited lower fetal Apgar scores than those of control subjects. The levels of cord blood neopterin were inversely correlated with an fetal Apgar score of 1 min in patients with GDM. Conclusions Patients with GDM had higher maternal and cord blood neopterin levels, and the cord blood neopterin levels are inversely associated with lower Apgar scores in women with GDM. The neopterin levels might be potential predictors of low fetal Apgar scores in women with GDM.