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Öğe Chronic Kidney Disease in Children in Turkey(2009) Bek, Kenan; Akman, Sema; Bilge, Ilmay; Topaloğlu, Rezan; Çalışkan, Salim; Peru, Harun; Cengiz, Nurcan; Söylemezoğlu, Oğuz[Abstract not Available]Öğe Etiology and Outcome of Acute Kidney Injury in Children(Springer, 2010) Düzova, Ali; Bakkaloğlu, Ayşin; Kalyoncu, Mukaddes; Poyrazoğlu, Hakan; Delibaş, Ali; Özkaya, Ozan; Peru, Harun; Alpay, Harika; Söylemezoğlu, Oğuz; Gür Güven, Ayfer; Bak, Mustafa; Bircan, Zelal; Cengiz, Nurcan; Akil, İpek; Özçakar, Birsin; Uncu, Nermin; Karabay Bayazit, Aysun; Sönmez, FerahThe aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged > 1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged > 1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged > 1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged > 1 month.