Etiology and Outcome of Acute Kidney Injury in Children
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged > 1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged > 1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged > 1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged > 1 month.
Açıklama
Anahtar Kelimeler
Epidemiology, Mortality, pRIFLE, Prognosis
Kaynak
Pediatric Nephrology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
25
Sayı
Künye
Düzova, A., Bakkaloğlu, A., Kalyoncu, M., Poyrazoğlu, H., Delibaş, A., Özkaya, O., Peru, H., Alpay, H., Söylemezoğlu, O., Gür Güven, A., Bak, M., Bircan, Z., Cengiz, N., Akil, İ., Özçakar, B., Uncu, N., Karabay Bayazit, A., Sönmez, F., (2010). Etiology and Outcome of Acute Kidney Injury in Children. Pediatric Nephrology, (25), 1453-1461. Doi: 10.1007/s00467-010-1541-y
