Etiology and Outcome of Acute Kidney Injury in Children

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dc.contributor.authorDüzova, Ali
dc.contributor.authorBakkaloğlu, Ayşin
dc.contributor.authorKalyoncu, Mukaddes
dc.contributor.authorPoyrazoğlu, Hakan
dc.contributor.authorDelibaş, Ali
dc.contributor.authorÖzkaya, Ozan
dc.contributor.authorPeru, Harun
dc.contributor.authorAlpay, Harika
dc.contributor.authorSöylemezoğlu, Oğuz
dc.contributor.authorGür Güven, Ayfer
dc.contributor.authorBak, Mustafa
dc.contributor.authorBircan, Zelal
dc.contributor.authorCengiz, Nurcan
dc.contributor.authorAkil, İpek
dc.contributor.authorÖzçakar, Birsin
dc.contributor.authorUncu, Nermin
dc.contributor.authorKarabay Bayazit, Aysun
dc.contributor.authorSönmez, Ferah
dc.date.accessioned2020-03-26T17:48:30Z
dc.date.available2020-03-26T17:48:30Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged > 1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged > 1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged > 1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged > 1 month.en_US
dc.description.sponsorshipTurkish Academy of SciencesTurkish Academy of Sciences [A.D/TUBA-GEBIP/2006-6]en_US
dc.description.sponsorshipDr. Duzova is supported by The Turkish Academy of Sciences (Program to Reward Successful Young Scientists, A.D/TUBA-GEBIP/2006-6).en_US
dc.identifier.citationDüzova, A., Bakkaloğlu, A., Kalyoncu, M., Poyrazoğlu, H., Delibaş, A., Özkaya, O., Peru, H., Alpay, H., Söylemezoğlu, O., Gür Güven, A., Bak, M., Bircan, Z., Cengiz, N., Akil, İ., Özçakar, B., Uncu, N., Karabay Bayazit, A., Sönmez, F., (2010). Etiology and Outcome of Acute Kidney Injury in Children. Pediatric Nephrology, (25), 1453-1461. Doi: 10.1007/s00467-010-1541-y
dc.identifier.doi10.1007/s00467-010-1541-yen_US
dc.identifier.endpage1461en_US
dc.identifier.issn0931-041Xen_US
dc.identifier.issn1432-198Xen_US
dc.identifier.pmid20512652en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1453en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00467-010-1541-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24894
dc.identifier.volume25en_US
dc.identifier.wosWOS:000278951200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPeru, Harun
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEpidemiologyen_US
dc.subjectMortalityen_US
dc.subjectpRIFLEen_US
dc.subjectPrognosisen_US
dc.titleEtiology and Outcome of Acute Kidney Injury in Childrenen_US
dc.typeArticleen_US

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