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    Functional components, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of Salvia syriaca L.
    (TAYLOR & FRANCIS INC, 2017) Bahadori, Mir Babak; Dinparast, Leila; Zengin, Gökhan; Sarikurkcu, Cengiz; Bahadori, Shahram; Asghari, Behvar; Movahhedin, Nasrin
    Antidiabetic, anti-Alzheimer, general toxicity, and antioxidant activities of Salvia syriaca were evaluated. Phytochemical composition of the essential oil and methanolic extract of the plant were identified using gas chromatography-mass spectrometry and reverse-phase high-performance liquid chromatography-diode array detector techniques, respectively. Essential oil of S. syriaca exhibited strong cytotoxicity, antioxidant, a-amylase, and a-glucosidase inhibitory activities. Gas chromatography-mass spectrometry analysis showed that spathulenol (87.4%), isospathulenol (7.6%), and bornyl acetate (2.7%) are the major compounds in essential oil. High-performance liquid chromatography analysis indicated that rutin, quercetin, apigenin, rosmarinic acid, and ferulic acid are the most abundant phenolic components. S. syriaca could be considered as a valuable source of bioactive natural compounds for functional foods, medical, and pharmaceutical applications.
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    New Prospective Materials for Chemoprevention: Three Phlomis
    (SCIENCEDOMAIN INT, 2016) Uysal, Ahmet; Gunes, Erdogan; Sarikurkcu, Cengiz; Celik, Handan; Durak, Yusuf; Uren, Mehmet Cemil
    Aim: Plants are permanent sources of biologically active compounds, used by about 80% of the world population as manufactured drugs. The aims of this paper are to determine the mutagenic and antimutagenic activities of methanol, ethyl acetate and water extracts from Phlomis nissoli (PNM, PNE, PNW) Phlomis pungens var. pungens (PPM, PPE, PPW) and Phlomis armeniaca (PAM, PAE, PAW) against well-known mutagens. Methodology: Mutagenic/antimutagenic activities were determined by Ames test. Results: Extracts of P. nissoli, P. pungens and P. armeniaca were not mutagenic against TA98 and TA100 in the condition both with and without S9 mix. The strongest antimutagenic action was revealed by PNE extract at a dose of 5000 mu g/plate against 2-amino-flourene with 96% inhibition for TA98 with S9 mix. PNM extract alleviated the mutagenic action of 2-amino-anthracene and exhibited strong inhibition rates (93%, 78%, 57%, respectively) with S9 mix at all doses for TA100 strain. While PAE extract manifested 95%, 91% and 84% inhibition against 2-amino-flourene for TA98, it revealed 90%, 84%, and 87% inhibition ratios, respectively, making them as strongly antimutagenic against 2-amino-anthracene for TA100 with S9 mix. Conclusion: P. nissoli, P. pungens and P. armeniaca extracts have significant antimutagenic capacities and they can represent a good model for the development of new drug formulations in pharmaceutical industry and they could be used in food industry as chemoprevention agent.