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Öğe A Case of Myoclonic Symptoms After Streptococcal Infection: Possible PANDAS Variant(GALENOS YAYINCILIK, 2011) Ceylan, Mehmet Fatih; Selek, Salih; Zeytinci, Esra; Savas, HalukPediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is defined as exacerbation of obsessive-compulsive disorder and/or tic disorder after streptococcal infections. New accumulating evidence suggests that PANDAS have some variants such as infantile-onset type, adult-onset type, myoclonic type, and dystonic type. In this report, we present the case of a fifteen-year-old adolescent who had myoclonic symptoms in the shoulders and was first treated for epilepsy and later, for conversion disorder until the diagnosis of PANDAS was established. (Archives of Neuropsychiatry 2011; 48: 85-7)Öğe Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Gergerlioglu, H. Serdar; Savas, Haluk A.; Bulbul, Feridun; Selek, Salih; Uz, Efkan; Yumru, MehmetOxidant nitric oxide (NO) and antioxidant superoxide dismutase (SOD) have been implicated to play a role in the pathogenesis of bipolar disorders. This is the first prospective study aimed to evaluate NO levels and SOD activity in bipolar disorder (type I manic episode) (BD-ME). 29 inpatient subjects with BD-ME and 30 healthy controls were included. Serum NO levels and SOD activity have been studied at 1st (NO [1st] and SOD [1st] respectively) and 30th days (NO [30th] and SOD [30th] respectively) after treatment. The clinical outcome was measured by Bech-Rafaelson Mania Scale (BRMS). The mean NO [1st] (p <.001) and NO [30th] levels (p <.00 1) were higher than controls, but SOD [ I st] (p <.001) and SOD [30th] (p <.001) activities in BD-ME were lower than controls. SOD1 activity was higher than SOD [30th] (p <.001), while there was no significance in comparison between NO [1st] and NO [30th] (p <.05). SOD [30th] activity is negatively correlated with the number of previous manic attacks and NO [1st] was negatively correlated with sleep item score of BRMS at first day. Also there was a significant correlation between NO [1st] levels and with the existence of a delusion. NO and SOD appear to play a role in the pathophysiological events occurring in BD, especially in BD-ME. This study for the first time showed the possible role of NO on sleep and the generation of delusions in the pathophysiology of BD. In the light of literature, induced glutamate pathway might be responsible for delusions in BD. The results of this research need further investigation to understand the oxidative vs antioxidative process in BD. (c) 2007 Elsevier Inc. All rights reserved.Öğe Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment (vol 31, pg 697, 2007)(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Gergerlioglu, H. Serdar; Savas, Haluk A.; Bulbul, Feridun; Selek, Salih; Uz, Efkan; Yumru, Mehmet[Abstract not Available]Öğe Correlation Between Metabolic Syndrome and Serum Ghrelin Levels in Bipolar Patients(AVES, 2010) Kalenderoğlu, Aysun; Savaş, Haluk A.; Gergerlioğlu, H. Serdar; Başaralı, Kemal; Yumru, Mehmet; Selek, Salih; Büyükbaş, Sadık; Ergene, NeyhanAmaç: Bu araştırmada ikiuçlu bozukluk hastalarında serum ghrelin düzeyleri ve Metabolik Sendrom (MetS) arasında bir ilişkinin olup olmadığının incelenmesi amaçlanmıştır. Yöntemler: Altmış ikiuçlu bozukluk hastası ve 30 sağlıklı gönüllü çalışmaya da- hil edildi. Hasta grubu atipik antipsikotik (risperidon, ketiapin, olanzapin) ve duy- gudurum düzenleyici (lityum, valproik asit, karbamazepin, lamotrijin) kullanımı- na göre iki ayrı gruba ayrıldı. Serum ghrelin seviyeleri insan ghrelin ELISA kitle- ri aracılığıyla ölçüldü. Hasta grubunda, NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) ölçütlerine göre MetS tanısı aşağıdakilerden 3 ya da daha fazlasının karşılanması ile değerlendirilmiştir. Bulgular: Çalışmaya alınan bipolar hastaların %51.7'si (n=31) sadece atipik an- tipsikotik (AA) tedavisi alırken, %48.8'ü (=29) sadece duygudurum düzenleyeci- si (DD) kullanıyordu. Hasta grubunda %36.7 (n=22) hastaya MetS tanısı konul- muştur. Hasta grubunda MetS olan ve olmayanlar arasında ghrelin düzeyleri açısından anlamlı fark yoktu. İlaveten AA kullanan ve MetS gelişen hastalarda ghrelin düzeyleri açısından anlamlı fark yoktu. DD kullanan ve Mets geliştirmiş olan hastalarda ghrelin düzeyleri açısından anlamlı fark yoktu. Serum ghrelin seviyeleri kontrol grubu ile kıyaslandığında bipolar hastalarda anlamlı oranda düşük bulunmuştur. Sonuç: Çalışmamızda ikiuçlu bozukluk hastalarında genel populasyona oranla daha fazla oranda MetS görülmüştür. Serum ghrelin seviyeleri bipolar hastalar- da anlamlı düzeyde düşük bulundu. Bu sonucun kompansatuar bir mekanizma ile ilişkili olabileceği ya da hastalığı özgü farklı parametrelerin rol alabileceği düşünüldü.Öğe The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode(ELSEVIER SCIENCE BV, 2008) Selek, Salih; Savas, Haluk A.; Gergerlioglu, H. Serdar; Bulbul, Feridun; Uz, Efkan; Yumru, MehmetBackground and aims: Studies have already pointed out a possible pathophysiological role of oxidative and antioxidative molecules in bipolar disorder. We aimed to evaluate the activity and levels of antioxidant superoxide dismutase (SOD), and oxidant nitric oxide (NO), in bipolar I depressive episode (BD-DE) patients in a prospective design. Method: 30 BD-DE patients, diagnosed according to DSM IV, and 30 healthy volunteer controls were included. The serum levels of NO and SOD have been studied when admitted to hospital (1st) and on the 30th days. Clinical outcome was measured by Hamilton Depression Scale (HAM-D). The patients were allowed to have their treatments. One patient was dropped out due to insufficient sampling. Results: As in the previous studies, NO 1st day levels were significantly higher in patients and SOD 1st day activity was significantly low (p < 0.0 1). NO levels significantly decreased (p < 0.0 1) and normalized, as SOD activity significantly increased but did not reach to the controls' levels (p < 0.01) on the 30th day. Conclusion: Despite normalized NO levels, persistent low SOD activity might point out an oxidative imbalance in BD-DE. Chronic low SOD activity may be associated with incapacity of coping with oxidative stress. This research connotes the probable oxidative imbalance in BD-DE and discusses that phenomenon within the continuum of the disease state. (C) 2007 Elsevier B.V. All rights reserved.Öğe High catalase and low thiol levels in adult- ADHD patients(2014) Alpak, Gökay; Selek, Salih; Bulut, Mahmut; Bülbül, Feridun; Ünal, Ahmet; Virit, Osman; Kılıç, Osman Hasan Tahsinmaç: Erişkin dikkat eksikliği ve hiperaktivite bozukluğunun (E-DEHB) yaygınlığı %5 olarak tahmin edilmektedir. DEHB etyolojisine ilişkin bir çok hipotez vardır. Çocukluk çağı DEHB’nin nörobiyolojisine ilişkin bir çok araştırma yapılmış olmasına rağmen E-DEHB çalışmaları nispeten azdır. Birçok çalışmada oksidan aracılı nöronal hasarın birçok psikiyatrik hastalığın patofizyolojisinde rol oynayabileceği belirtilmiştir. Daha önce E-DEHB’de oksidatif stres çalışılmış ve sonuçlar bu rolü desteklemektedir. Bu çalışmada E-DEHB hastalarında katalaz (KAT) ve tiyol sevilerini çalışmayı ve sağlıklı kontrollerle karşılaştırmayı amaçladık. Yöntem: İki psikiyatrist tarafından uygulanan Erişkin DEH/DEHB DSM IV-Dayalı Tanı Tarama ve Ölçme Testinin Turgay’ın Türkçe versiyonuna göre tanı alan 25 E-DEHB hastası ve 25 sağlıklı kontrol dahil edildi. Denekler kesinlikle kan alımı öncesindeki günün 20:00’dan sonra herhangi bir madde alımı ve fiziksel egzersizden men edildiler. KAT ve tiyol çalışma gruplarının plazma örneklerinden ölçülmüştür. Bulgular: Hasta ve kontrollerin yaş, cinsiyet, ve beden kütle endeksleri homojenlik göstermiştir ve gruplar arasında fark yoktu. Toplam puan ve alt ölçek skorları ile belirtilen biyokimyasal parametreler arasında herhangi bir ilişki olmadığı saptandı. Hasta grubunda kontrol grubuna göre ortalama KAT düzeyleri daha yüksek ve Tiyolle düzeyleri daha düşüktü (sırasıyla; 0.001, 0.001). Psikiyatrik ekhastalığı olan hastalarla saf E-DEHB hastaları KAT (sırasıyla; 11.490.28, 11.510.40) ve tiyol (sırasıyla; 0.220.05, 0.250.03) seviyeleri açısından karşılaştırıldığında herhangi bir fark tespit edilmedi (sırasıyla; 0.865, 0.174). Sonuç: Çalışmamızın sonuçları tiyol sevilerindeki düşüşün KAT seviyelerindeki yüksekliğine bir tepki sonucu olduğu ve tiyolün çalışmamızda pro-oksidan gibi davrandığı işaret ediyor olabilir. Bu çalışma E-DEHB ve oksidatif stres arasındaki ilişkiyi aydınlatmak için yapılmış ilk aşama çalışmalarından biri olarak kabul edilebilir. Bu ilişkiyi net olarak ortaya koyacak ileri çalışmalara ihtiyaç vardır.Öğe High Catalase and Low Thiol Levels in Adult-ADHD Patients(KURE ILETISIM GRUBU A S, 2014) Alpak, Gökay; Selek, Salih; Bulut, Mahmut; Bülbül, Feridun; Ünal, Ahmet; Virit, Osman; Kılıç, Osman Hasan TahsinObjective: The prevalence of Adult attention-deficit/hyperactivity disorder (A-ADHD) has been estimated as to be around 5%. There are several hypotheses regarding the etiology of ADHD. Although numerous researches have been conducted regarding neurobiology of pediatric ADHD, A-ADHD studies were relatively few. Many studies have indicated that oxidant mediated neuronal damage may play a role in the pathophysiology of various psychiatric disorders. Recently, oxidative stress has been studied in A-ADHD and there is an accumulating evidence to support its' role. In the present study, we aimed to evaluate catalase (CAT) and thiol levels in A-ADHD patients and compare with healthy controls. Materials-Methods: Twenty-five A-ADHD patients from Gaziantep University, diagnosed according to Turgay's Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists, and 25 healthy volunteer controls were included. The subjects strictly refrained from any substance intake and physical exercise after 08:00 p.m. on the day before collection. CAT and Thiol levels were measured in plasma samples of study groups. Results: Age, gender, and body mass indexes of patients and controls have shown homogeneity and there were no differences between the groups. Total score and subscores were not correlated with any of the mentioned biochemical parameters. The mean CAT levels in patients with ADHD were significantly higher and Thiol levels were lower than those of controls (<0.001, <0.001, respectively). When the comorbid patient group compared with pure A-ADHD patients in terms of CAT (11.49 +/- 0.28, 11.51 +/- 0.40, respectively) and thiol (0.22 +/- 0.05, 0.25 +/- 0.03, respectively) levels there were not found any significant differences (p=0.865, p=0.174, respectively). Conclusions: The results of the present study may indicate that thiol levels may be decreased with in reaction of increased CAT levels and thiol act like a pro-oxidant. This study may be considered as one of the initial phase studies that lighten the relationship between oxidative stress and A-ADHD.There is a need for further studies that will prove this relationship exactly.Öğe Malondialdehyde levels in adult attention-deficit hyperactivity disorder(CMA-CANADIAN MEDICAL ASSOC, 2007) Bulut, Mahmut; Selek, Salih; Gergerlioglu, H. Serdar; Savas, Haluk A.; Yilmaz, H. Ramazan; Yuce, Murat; Ekici, GiyasettinObjective: To evaluate the biochemical basis of adult attention-deficit hyperactivity disorder (A-ADHD), we compared lipid peroxidation status in the plasma of A-ADHD patients, and that of control subjects without A-ADHD by quantifying the levels of malondialdehyde (MDA), an end product of fatty acid oxidation. We aimed to examine the association between MDA and A-ADHD. Method: The study comprised 20 A-ADHD patients from Gaziantep University Sahinbey Research Hospital Psychiatry Clinic, diagnosed by 2 psychiatrists (H.A.S. and S.S.) according to the Turkish version of the adult ADD/ADHD DSM-IV-Based Diagnostic Screening and Rating Scale, and 21 healthy volunteers. Malondialdehyde levels were measured in plasma samples of both study groups, Results: The mean (standard deviation [SD]) MDA levels in patients (2.44 [0.84] nmol/mL) were significantly higher than those of control subjects (0.36 [0.20] nmol/mL) (t = 11.013, of = 39, p < 0.01). MDA levels were correlated with overall number of criteria met (n = 20, p = 0.01, Ro = 0.56) and total hyperactivity/impulsivity score(n = 20, p = 0.02, Ro = 0.51). Conclusion: The fact that MDA levels were increased in A-ADHD could be an indication of increased oxidative stress in this disease. We suggest that such changes may have a pathological role in A-ADHD. This is the first study evaluating the MDA levels in A-ADHD, and our findings may provide a scientific guide for the further clinical enzymologic and biochemical studies on this disorder.Öğe Oxidative imbalance in adult attention deficit/hyperactivity disorder(ELSEVIER SCIENCE BV, 2008) Selek, Salih; Savas, Haluk A.; Gergerlioglu, H. Serdar; Bulut, Mahmut; Yilmaz, H. RamazanObjective: There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not. Methods: Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured. Results: The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls. Conclusions: Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD. (C) 2008 Elsevier B.V. All rights reserved.Öğe Oxidative Imbalance in Adult Attention Deficit/Hyperactivity Disorder -- 2(ELSEVIER SCIENCE INC, 2009) Selek, Salih; Savas, Haluk A.; Gergerlioglu, Hasan Serdar; Bulut, Mahmut; Yilmaz, H. Ramazan[Abstract not Available]
