Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Küçük Resim Yok

Tarih

2007

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

PERGAMON-ELSEVIER SCIENCE LTD

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Oxidant nitric oxide (NO) and antioxidant superoxide dismutase (SOD) have been implicated to play a role in the pathogenesis of bipolar disorders. This is the first prospective study aimed to evaluate NO levels and SOD activity in bipolar disorder (type I manic episode) (BD-ME). 29 inpatient subjects with BD-ME and 30 healthy controls were included. Serum NO levels and SOD activity have been studied at 1st (NO [1st] and SOD [1st] respectively) and 30th days (NO [30th] and SOD [30th] respectively) after treatment. The clinical outcome was measured by Bech-Rafaelson Mania Scale (BRMS). The mean NO [1st] (p <.001) and NO [30th] levels (p <.00 1) were higher than controls, but SOD [ I st] (p <.001) and SOD [30th] (p <.001) activities in BD-ME were lower than controls. SOD1 activity was higher than SOD [30th] (p <.001), while there was no significance in comparison between NO [1st] and NO [30th] (p <.05). SOD [30th] activity is negatively correlated with the number of previous manic attacks and NO [1st] was negatively correlated with sleep item score of BRMS at first day. Also there was a significant correlation between NO [1st] levels and with the existence of a delusion. NO and SOD appear to play a role in the pathophysiological events occurring in BD, especially in BD-ME. This study for the first time showed the possible role of NO on sleep and the generation of delusions in the pathophysiology of BD. In the light of literature, induced glutamate pathway might be responsible for delusions in BD. The results of this research need further investigation to understand the oxidative vs antioxidative process in BD. (c) 2007 Elsevier Inc. All rights reserved.

Açıklama

Anahtar Kelimeler

antimanic treatment, antioxidant, bipolar disorder, delusion, nitric oxide, oxidant, sleep, superoxide dismutase

Kaynak

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

31

Sayı

3

Künye