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Öğe Aripiprozole-induced diplopia: A case report(2013) Atlı, Abdullah; Selvi, Yavuz; Aydın, Yıldız; Kaya, Mehmet CemalDiplopi çift görme olarak tanımlanan ve yaşam kalitesini bozan bir durumdur. Akut diplopi bazı genel tıbbi ilaçlar ve psikotrop ilaç kullanımında görülmektedir. Aripiprazol D2 ve 5-HT1A reseptörlerine parsiyel agonist ve 5-HT2A reseptörlerine antagonist aktivite gösteren atipik antipsikotik ajandır. Bu yazıda şizofreniform bozukluk tanısıyla takip edilen 24 yaşındaki bir hastada, oral aripiprazol kullanımını takiben ortaya çıkan, diplopi olgusu bildirilmektedir. Klinisyenler aripiprazol tedavisiyle diplopi ortaya çıkabileceğini akılda tutmalıdırlar.Öğe Aripiprozole-Induced Diplopia: A Case Report(KURE ILETISIM GRUBU A S, 2013) Atli, Abdullah; Selvi, Yavuz; Yildiz, Aydin; Kaya, Mehmet CemalDiplopia is a condition that involves seeing double and impairs quality of life. Acute diplopia can be seen with some general medical drugs and psychotropic drugs. Aripiprazole is a new atypical antipsychotic agent; it has partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. This paper reports development of diplopia, a rare adverse effect of psychotropic drugs, in a 24 year old patient with schizophreniform disorder following use of oral aripiprazole. Clinicians should keep in mind that diplopia may occur with aripiprazole treatment.Öğe Assessment of the effects of antihistamine drugs on mood, sleep quality, sleepiness, and dream anxiety(TAYLOR & FRANCIS LTD, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, SevdaObjective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(EDIZIONI MINERVA MEDICA, 2016) Bilgiç, Özlem; Bilgiç, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Ünlü, Ali; Altınyazar, Hilmi CevdetBACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Benefits of submucous resection on sleep quality, daytime and dream anxiety in patients with nasal septal deviation(SPRINGER LONDON LTD, 2013) Gulec, Tezay Cakin; Yoruk, Ozgur; Gulec, Mustafa; Selvi, Yavuz; Boysan, Murat; Oral, Elif; Yucel, AtakanThe aim of this report was to assess the frequency of poor sleep quality, daytime and dream anxiety and their response to subsequent surgical treatment for a representative group of 68 patients with nasal septum deviation. Nasal airflows and airway resistances were measured using rhinomanometry and the participants were also asked to fill in Pittsburgh Sleep Quality Index, Beck Anxiety Inventory, and Van Dream Anxiety Scale directly before the submucous resection without turbinectomy and 2 months later. Repeated measure analyses of variance models showed that patients reported significantly lower scores of poor sleep quality, daytime anxiety, and as well as dream anxiety after surgical treatment (P < 0.01). Nasal septal surgery might have beneficial effects on sleep variables in patients with deviation.Öğe Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder(PHYSICIANS POSTGRADUATE PRESS, 2015) Ozdemir, Pinar Guzel; Boysan, Murat; Smolensky, Michael H.; Selvi, Yavuz; Aydin, Adem; Yilmaz, EkremObjective: Phototherapy, ie, bright light therapy, is an effective and safe treatment of major depressive disorder (MDD). It exerts rapid mood-elevating activity, similar to antidepressant medications, most likely mediated through both monoaminergic and circadian system melatonergic mechanisms. We assessed the efficiency of bright light therapy as an adjuvant treatment to antidepressant pharmacotherapy in patients with severe MDD randomized by Hamilton Depression Rating Scale (HDRS) score to either (1) 150 mg venlafaxine hydrochloride daily at 7: 00 am or (2) 150 mg venlafaxine plus 60-minute light of 7000 lux the initial week of clinical management (venlafaxine + bright light therapy) daily at 7: 00 am. Method: 50 inpatients with severe MDD at the Psychiatry Clinic of Yuzuncu Yil University Training and Education Hospital participated. The study, which was conducted from January 2013 through June 2014, entailed patients diagnosed with severe MDD based on DSM-IV-TR for the first time. Mood states were assessed by the HDRS, Profile of Mood States (POMS), and Beck Depression Inventory (BDI) before treatment and at 1, 2, 4, and 8 weeks of treatment. Results: On the basis of the HDRS score as the primary outcome variable, both strategies significantly improved depression and negative mood states already at the first treatment week (P < .001). Differences in therapeutic effects by treatment strategy were remarkable at the second and fourth weeks of clinical management (P = .018 and P = .011, respectively), with beneficial effects continuing until trial Conclusion. Those treated with venlafaxine + bright light therapy evidenced significantly lower HDRS depression scores (P < .05) as well as BDI scores (P < .05) and POMS negative mood states scores (depression-dejection, tension-anxiety, anger-hostility, fatigue-inertia, and confusion-bewilderment subscales; all P < .05) after the second week. At week 4 of the trial, 19 (76%) of the 25 venlafaxine + bright light therapy patients versus just 11 (44%) of the 25 venlafaxine patients (P < .05) attained the target goal of treatment, a HDRS score = 13, indicative of mild depression, and, although not statistically significant in our small sample study (P = .36), at week 8, 76% of venlafaxine + bright light therapy patients (n = 19) versus just 64% of the venlafaxine patients (n = 16) experienced complete remission of depression (HDRS score = 7). Conclusions: Both venlafaxine and venlafaxine + bright light therapy treatment strategies significantly reversed the depressive mood of patients with severe MDD; however, the latter induced significantly stronger and more rapid beneficial effects. Future longer-term studies with large sample sizes, nonetheless, are required to confirm and generalize these results to patients of diverse ethnicities and cultures with both severe and mild MDD. (C) Copyright 2015 Physicians Postgraduate Press, Inc.Öğe Delusional Misidentification Syndromes: A Case of Intermetamorphosis(KLINIK PSIKIYATRI DERGISI, 2017) Kandeger, Ali; Tekdemir, Rukiye; Selvi, YavuzDelusional Misidentification Syndromes (SYTS) are considered to be uncommon psychopathological phenomena countered in psychiatric and neurological cases. It is defined as the delusions in which the person believes that the persons, places, objects and events around the person have changed or proliferated. Intermetamorphosis is a phenomenon in which there is a marked increase in familiarity and the physical and mental identities of familiar or unfamiliar people change and become a familiar person to the patient. Intermetamorphosis is the rarest syndromes among SYTS and was termed by Courbon and Tusques in 1932. In this article, a case of intermetamorphosis syndrome in a patient diagnosed with schizophrenia will be presented.Öğe Depresyon hastalarında Aleksitiminin bedenselleştirme ve uyku kalitesi üzerine etkisi(2013) Aydın, Adem; Selvi, Yavuz; Güzel, Pınar ÖzdemirÖZET Amaç: Bu çalışmanın amacı, depresyon tanılı hastalarda aleksitiminin bedenselleştirme eğilimleri ve uyku kalitesi üzerine etkisinin incelenmesidir. Yöntem: Çalışmaya psikiyatri polikliniğine başvuran ve depresyon tanısı alan 85 hasta dâhil edilmiştir. Hastalara Beck Depresyon Ölçeği (BDÖ), Toronto Aleksitimi Ölçeği (TAÖ), Belirti Yorumlama Ölçeği (BYÖ) ve Pittsburgh Uyku Kalitesi İndeksi (PUKİ) uygulanmıştır. Bulgular: Depresif hastalar aleksitimik olanlar ve aleksitimik olmayanlar şeklinde iki gruba ayrıldı. Aleksitimi özelliği bulunan hastalarda BDÖ puanları, ruhsal atıf ve bedenselleştiren atıf puanları, PUKİ alt bölümlerinden gündüz işlevsellik kaybı puanlarının anlamlı ölçüde farklılık gösterdiği tespit edildi. Sonuç: Bu çalışmada depresyon hastalarında aleksitimi özelliklerinin ve bedenselleştirme eğilimlerinin yüksek olduğu bulunmuştur. Üstelik aleksitimik olan hastaların ruhsal ve bedensel atıfları daha sık olup gündüz işlevsellik kayıpları da artmıştır. (Nöropsikiyatri Arflivi 2013; 50: 65-69)Öğe Dissociative Symptoms Secondary to Piracetam: A Case Report(KURE ILETISIM GRUBU A S, 2013) Aydin, Adem; Ozdemir, Pinar Guzel; Selvi, Yavuz; Uguz, Faruk; Cetinkaya, NuralayPiracetam is a cyclic derivative of gamma-aminobutyric acid that is often used in neurology. Piracetam is an antithrombotic, neuroprotective agent which improves cognitive performance. Piracetam is indicated for vertigo in clinical practice. The etiology of dissociation is not precisely defined. In pharmacotherapy studies, depersonalization is the basic dissociative symptom. In this article, we have reported a case with the diagnosis of peripheral vertigo where piracetam was used as part of combination therapy. However dissociative symptoms like depersonalization and derealization occurred after piracetam use and these symptoms disappeared after discontinuation of piracetam.Öğe The Effect of Alexithymia on Somatization and Sleep Quality in Patients with Depression(AVES, 2013) Aydin, Adem; Selvi, Yavuz; Guzel Ozdemir, PinarBackground: The aim of the study was to determine the effect of alexithymia on sleep quality and tendency to somatization in patients with depression. Methods: Eighty-five patients with depression, who applied to the outpatient unit of psychiatry, were included in the study. The Beck Depression Inventory (BDI), Toronto Alexithymia Scale (TAS), Symptom Interpretation Questionnaire (SIQ), and the Pittsburgh Sleep Quality Index (PSQI) were administered to the patients. Results: Depressive patients were divided into two groups: alexithymic patients and non-alexithymic patients. There were significant differences in scores of BDI, psychologizing and somatizing subscale of the SIQ and daytime dysfunction subscale of the PSQI in alexithymic patients. Conclusion: It was found that depressive patients have higher levels of alexithymic features and somatization tendencies in this study. Moreover, alexithymic patients have more frequent psychological and somatic attributions and increased loss of daytime functionality. (Archives of Neuropsychiatry 2013; 50: 65-69)Öğe The Effect of the Social and Independent Living Skills, the Community Re-entry Program Application for Patients with Schizophrenia on their Functional Remission and Drug Adherence(Taylor and Francis Ltd., 2017) Okanlı, Ayşe; Karakaş, Sibel Asi; Altun, Özlem Şahin; Selvi, YavuzThis research has been conducted to determine the effect of “social and independent living skills, the community re-entry program” implemented in schizophrenic patients on the functionalities and medication compliance. The research sample included 30 patients with schizophrenia. After evaluating the patients with questionnaires, the FROGS (Functional Remission of General Schizophrenia) Scale, Morisky Compliance Scale and Drug Attitude Inventory, the “Social and Independent Living Skills, The Community Re-entry Program” (SILSCRP) has been applied, and the same tests have been reapplied after the 6th month of the training to the patients who had been followed up by monthly phone calls. Evaluating the average scores of the functional recovery scale and its subscales in schizophrenia patients, it has been found that the overall total score was 52.1 and the Social Functioning Subscale total score was 19.6, respectively. It has been determined in the paper that the SILSCRP training given to the patients with schizophrenia has affected the functionalities and the medication compliance of the patients positively. The SILSCRP training program has increased the functionalities and medication compliance of the patients with schizophrenia. Training and rehabilitation in the chronic mental disorders should be prominent in our country. © 2017 Kamla Raj.Öğe The effects of biological rhythms and sleep quality on benign paroxysmal positional vertigo and reflux symptom severity(TAYLOR & FRANCIS LTD, 2017) Celiker, Metin; Selvi, Yavuz; Ozgur, Abdulkadir; Terzi, Suat; Boysan, Murat; Polat, Hatice Beyazal; Dursun, EnginRecently, there has been increased interest in chronotypes and clinical differences between them. However, there is limited information about the potential influence of the chronotypes on clinical manifestations and symptom intensity of somatic diseases. The aim of this study is to evaluate the impact of biological rhythm differences and sleep quality on benign paroxysmal positional vertigo (BPPV) and larengo pharyngeal reflux (LPR) severity. Forty-four LPR patients, 43 BBPV patients and 42 controls were included in the study. The morningness-eveningness questionnaire was used to determine chronotypes, and the Pittsburgh Sleep Quality Index was used to assess subjective sleep quality. Both patient groups reported a significantly greater tendency to eveningness diurnal preferences compared to healthy controls. As with the circadian preferences, patients with BPPV or LPR characterized by poorer sleep quality and worse insomnia than non-patient individuals. It can be concluded that the circadian rhythm and sleep quality are related to the severity of LPR and BPPV.Öğe The Effects of Individual Biological Rhythm Differences On Sleep Quality, Daytime Sleepiness and Correlations with Dissociative Experiences(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2015) Selvi, Yavuz; Kandeğer, Ali; Boysan, Murat; Akbaba, Nursel; Uygur, Ömer F.; Sayın, Ayça A.; Tekinarslan, Emine[Abstract not Available]Öğe The effects of individual biological rhythm differences on sleep quality, daytime sleepiness, and dissociative experiences(ELSEVIER IRELAND LTD, 2017) Selvi, Yavuz; Kandeger, Ali; Boysan, Murat; Akbaba, Nursel; Sayin, Ayca A.; Tekinarslan, Emine; Koc, Basak O.Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables. Among several other psychological functions, dissociation may also lead to disruption and alteration of consciousness, which may facilitate dream-like experiences. Our study was aimed at an inquiry into the effects of individual biological rhythm differences on sleep quality and daytime sleepiness in conjunction with dissociative experiences. Participants were 372 undergraduate college students, completed a package of psychological instruments, including the Morningness-Eveningness Questionnaire, Dissociative Experiences Scale, Insomnia Severity Index, and Epworth Sleepiness Scale. Using logistic regression models, direct relations of pathological dissociation with sleepiness, sleep quality and circadian preferences were investigated. Poor sleep quality and sleepiness significantly contributed to the variance of dissociative symptomatology. Although there was no substantial linear association between circadian preferences and pathological dissociation, having evening-type preferences of sleep was indirectly associated with higher dissociation mediated by poor sleep quality. Poor sleep quality and daytime sleepiness seems to be significant antecedents of pathological dissociation. Sleep chronotype preferences underlie this relational pattern that chronobiological characteristics seem to influence indirectly on dissociative tendency via sleep quality.Öğe Effects of shift work on attention deficit, hyperactivity, and impulsivity, and their relationship with chronotype(TAYLOR & FRANCIS LTD, 2015) Selvi, Fatma Feray; Karakas, Sibel Asi; Boysan, Murat; Selvi, YavuzThere is growing evidence that shift-work schedules cause severe disturbances to circadian rhythms and the sleep-wakefulness cycle, and that these changes in turn lead to cognitive and behavioral problems. The objective of this study is to explore the relationships between biological rhythm differences (chronotype) and impulsive behaviors and attention-deficit hyperactivity symptoms in shift workers. Seventy-nine nurses working in the daytime and 127 nurses working on night shifts were evaluated with the Barratt Impulsiveness Scale, Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS), and Morningness-Eveningness questionnaire for identifying circadian preference. It was found that shift workers had more attention deficit (p.05) and impulsivity (p.01) when compared with daytime workers. Morning-type workers reported lower hyperactivity and ASRS total scores than evening- and intermediate-type workers. The mean impulsivity score of evening-type workers was higher than both the other groups (p.05). It has been shown that attention deficit, hyperactivity, and impulsivity levels that appear as a result of working shifts might change in accordance with the individual's chronotype. It might, therefore, be desirable to evaluate an individual's chronotype to establish suitability for working shifts.Öğe The Effects of Sleep Deprivation on Dissociation and Profiles of Mood, and Its Association with Biochemical Changes(GALENOS YAYINCILIK, 2015) Selvi, Yavuz; Kilic, Sultan; Aydin, Adem; Ozdemir, Pinar GuzelIntroduction: Sleep deprivation is a method, which has being used in order to comprehend the functions of sleep both in healthy individuals and for the patients of depression with in treatment, for a long time. The objective of our present study is to examine the relation between hormonal values, which are known for being related to the effects of these said changes determined in the mood, dissociation and thought suppression in healthy individuals after one night of sleep deprivation implementation. Methods: One night sleep deprivation was performed on a total of thirty-two healthy volunteers (16 males and 16 females) who were included in the study. Blood samples were taken from the individuals before and after sleep deprivation implementation in order to determine cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and Thyroid Functions' Levels tests. In order to evaluate the effects of the sleep deprivation on moods, "White Bear Suppression Inventory (WBSI)" has been conducted, with an aim of evaluating thought suppression, "Profile of Mood States (POMS)", "Dissociative Experiences Scale (DES)" with a purpose of realizing any dissociation tendency. Results: On the individuals who have been implemented for sleep deprivation, a decrease on depression and vigor-activity sub-scales values was detected, and an increase was determined on fatigue sub-scales values of "POMS". While the values of DES were found to have been statistically increased after sleep deprivation, also a significant decrease was determined on WBSI values. Even if there hasn't been any significant statistical change determined on cortisol levels after sleep deprivation, yet there had been some significant changes detected on Thyroid Stimulating Hormone (TSH), fT3, fT4, and DHEA-S levels. Decrease in "POMS" depression sub-scale values and increase on fatigue sub-scale values were determined on the individuals whose sT4 levels were found to be increased significantly in statistic manner after the sleep deprivation. Conclusion: According to the results of our study, sleep deprivation for one night was determined to cause decrease on depressive mood, increase on dissociative symptoms and to lower the tendency of suppressing the unwanted thoughts, consciously. The fact of being obtained lower depression values, on the individuals with the increased DHEA-S levels after the sleep deprivation meets with the information claiming that the high DHEA-S levels may be deemed as protectors against the negative effects of the stress.Öğe Evaluation of the Relationship between Major Depressive Disorder and Bereavement Symptoms in Elderly Patients Who Present Either to Psychiatry or Family Medicine(AVES, 2016) Taymur, Ibrahim; Ozdel, Kadir; Aypak, Cenk; Duyan, Veli; Turedi, Ozlem; Gungor, Buket Belkiz; Selvi, YavuzIntroduction: We aimed to determine the level of bereavement and depression symptoms among elderly patients who experience the loss of a significant other and the relationship between depressive symptoms and bereavement symptoms. Methods: The study sample consisted of elderly adults who lost a significant other at least 6 months prior to the submission time. Participants were recruited from patients who presented to either the psychiatry or family medicine outpatient unit of a Training and Research Hospital. Cognitive functions were assessed using Standardized Mini Mental Examinations for Educated and Uneducated People (SMME/SMME-U). Participants were excluded from the study if their SMME or SMME-U scores were lower than 23 points. To assess the severity of depressive and bereavement symptoms, the Geriatric Depression Scale (GDS) and Core Bereavement Items (CBI) scales were used, respectively. Results: Overall, 33 out of 67 individuals (49.2%) who presented to the psychiatry unit and 7 out of the 43 individuals (16.3%) who presented to the family medicine unit were diagnosed with major depressive disorder (MDD). CBI scale score means were higher in the MDD groups than in the non-depressive groups (p=0.012 and p=0.001, respectively). CBI scores were significantly correlated to acute (p=0.047) and chronic stress (p=0.007) in the psychiatry group and to chronic stress in the family medicine group (p=0.001). Conclusion: Probing loss experiences and reactions to them can be important to understand depression, to evaluate its symptoms, and to help manage the relevant symptoms. Considering the significant contributions of bereavement to depressive symptom severity in elders, interventions specific to bereavement symptoms should not be ignored.Öğe Farklı Klinik Semptomlarla Ortaya Çıkan Narkolepsi Olguları(2013) Özdemir, Pınar Güzel; Aydın, Adem; Selvi, YavuzNarkolepsi, nadir görülen ve az tanynan ve atlanan birdurumdur. Aşırı gündüz uykululuğu, katapleksi, uykuparalizisi, hipnogojik ve hipnopompik varsanylarla karakterize bir bozukluktur. Gündüz aşırı uykululuğunarkolepsinin en önemli belirtisidir ve diğer psikiyatrikbozukluklarla karışabilir. Hastalığın katapleksi ile birlikteolan ve katapleksi ile birlikte olmayan şeklinde, birincilveya tıbbi duruma ikincil formları vardır. Çevresel vegenetik faktörlerin karmaşık bir etkileşimi neticesindeortaya çıktığı düşünülmektedir. Narkolepsi tanısı klinikolarak konmaktadır. Bununla birlikte son zamanlardanarkolepsi tanısında uyku bozuklukları tıbbı alanındaönemli gelişmeler olmuştur. Stimülanlar, modafinil veantidepresanlar narkolepside tedavide kullanılanilaçlardır. Narkolepsinin farklı klinik belirtileri diğer psikiyatrik hastalıklarla örtüşebilir. Bu yazyda iki olgu sunumuyapılmıştır. İlk olgu, klinik belirtileri açısından epilepsitanısını düşündüren, antiepileptik tedavi başlanan ancaktedaviden yanıt alynamayan, ayrıntılı incelemelerlenarkolepsi tanısı konduktan sonra başarılı şekilde tedaviedilen bir olgudur. ikincisi ise depresif semptomlarlabaşlayan ve depersonalizasyon, derealizasyon semptomlary olup antidepresan tedaviden fayda görmeyen birolgudur. Hasta narkolepsi tanısı konulduktan sonrastimülan ajanlarla başarılı bir şekilde tedavi edilmiştir.Narkolepsi belirtilerini tanıma ve farkındalık, bu hastalığa uygun zamanda tanı konmasını ve uygun tedavininuygulanmasını sağlar. Dolayısıyla, klinisyenlernarkolepsinin farklı klinik görünümleri konusundadikkatli olmalıdırlarÖğe Heterogenity of Sleep Quality in Relations Between Cirdadian Preferences and Depressive Symptomatology Among Major Depression Patients(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2015) Selvi, Yavuz; Uygur, Ömer F.; Boysan, Murat; Kandeğer, Ali; Sayın, Ayça A.; Akbaba, Nursel; Koç, Başak[Abstract not Available]Öğe Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-beta peptide in high-fat and high-sucrose-fed rats(CAMBRIDGE UNIV PRESS, 2017) Selvi, Yavuz; Gergerlioğlu, Hasan Serdar; Akbaba, Nursel; Öz, Mehmet; Kandeğer, Ali; Demir, Enver Ahmet; Yerlikaya, Fatma HümeyraObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.
