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    Activity of essential oils and individual components against acetyl and butyrylcholinesterase
    (WALTER DE GRUYTER GMBH, 2008) Orhan, Ilkay; Kartal, Murat; Kan, Yueksel; Sener, Bilge
    We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical fertilizers), two from Mentha piperia L. and M. spicata L. (organic fertilizer), two from Lavandula officinalis Chaix ex Villars (Cultivated using organic and chemical fertilizers), two from Ocimum basilicum L. (green and purple-leaf varieties cultivated using only organic fertilizer), four from Origanum onites L., O. vulgare L., O. munitiflorum Hausskn., and O. majorana L. (cultivated using organic fertilizer), two from Salvia sclarea L. (organic and chemical fertilizers), one from S officinalis L. (organic fertilizer), and one from Satureja cuneifolia Ten. (organic fertilizer) by a spectrophotometric 1 mg/ml concentration. In addition, a method of Ellman using ELISA microplate-reader at 1 mg/ml number of single components widely encountered in most of the essential oils [gamma-terpinene, 4-allyl anisole, (-)-carvone, dihydrocarvone. (-)-phencone, cuminyl alcohol, cumol, 4-isopropyl benzaldehyde, trans-anethole, camphene, iso-borneol, (-)-borne0l, L-bornyl acetate. 2-decanol, 2-heptanol, methyl-heptanol, farnesol, nerol, iso-pulegol, 1,8-cineole, citral, citronellal, citronellol, geraniol, linalool, alpha-pinene, beta-pinene, piperitone, iso-menthone. menthofurane, linalyl oxide, linalyl ester, geranyl ester, carvacrol, thymol, menthol, vanilline, and eugenol] was also screened for the same activity in the same manner. Almost all of the essential oils showed a very high inhibitory activity (over 80%) against both enzymes, whereas the single components were not as active as the essential oils.
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    Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Wild and Cultivated Samples of Sage (Salvia fruticosa) by Activity-Guided Fractionation
    (MARY ANN LIEBERT INC, 2011) Senol, Fatma Sezer; Orhan, Ilkay Erdogan; Erdem, Sinem Aslan; Kartal, Murat; Sener, Bilge; Kan, Yuksel; Celep, Ferhat
    In European folk medicine, Salvia species have traditionally been used to enhance memory. In our previous study of 55 Salvia taxa, we explored significant anticholinesterase activity of cultivated S. fruticosa. In this study, we compared the inhibitory activity of dichloromethane, ethyl acetate, and ethanol extracts of 3 wild-grown samples and 1 cultivated sample of S. fruticosa against acetylcholinesterase and butyrylcholinesterase enzymes (which are associated with pathogenesis of Alzheimer's disease) by using the spectrophotometric Ellman method. Antioxidant activities were assessed by determining 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, iron-chelating capacity, and ferric-reducing antioxidant power. The dichloromethane extract of the cultivated sample was then subjected to fractionation by using open column chromatography and medium-pressure liquid chromatography to obtain the most active fraction by activity-guided fractionation. All fractions and subfractions were tested in the same manner, and inactive subfractions were discarded. The essential oil of the cultivated sample was analyzed by gas chromatography-mass spectrometry.
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    In-vitro Neuroprotective Properties of the Maydis Stigma Extracts From Four Corn Varieties
    (Taylor & Francis Ltd, 2012) Kan, Asuman; Orhan, Ilkay; Coksarı, Gulay; Sener, Bilge
    Neuroprotective effect of the ethyl acetate and ethanol extracts of the silks of four Zea mays L. varieties (var. intendata, var. indurata, var. everta and var. saccharata) was evaluated by acetylcholinesterase, butrylcholinesterase and tyrosinase inhibitions and by antioxidant activity tests against 2,2-diphenyl-1-picrylhydrazyl and superoxide as well as two iron-related antioxidant methods (iron-chelation capacity and ferric-reducing antioxidant power). Total phenol and flavonoid contents in the extracts were determined spectrophotometrically.
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    Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr
    (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018) Ayaz, Fatma; Kucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Background: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bioassays such as cytotoxicity on brine shrimps, phytotoxicity against Lemna minor and insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The n-hexane and chloroform fractions showed significant phytotoxic activity (100 % growth inhibition) at 1000 mu g/ml against L. minor. The brine shrimp lethality test revealed that the chloroform and remaining water fractions of C. dichotomum have moderate and positive lethality with LD50 values of 169.48 and 46.26 mu g/mL, respectively. In addition, the chloroform and n-butanol fractions had low and moderate insecticidal activity with 20 and 40 % of mortality against Tribolium castaneum, respectively. Conclusion: This study demonstrates that C. dichotomum consists of bioactive constituents responsible for phytotoxicity, cytotoxicity on brine shrimps and insecticidal activity.
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    Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr.
    (ASSOC PHARMACEUTICAL TEACHERS INDIA, 2018) Ayaz, Fatma; Mucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Background: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bioassays such as cytotoxicity on brine shrimps, phytotoxicity against Lemna minor and insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The n-hexane and chloroform fractions showed significant phytotoxic activity (100 % growth inhibition) at 1000 mu g/ml against L. minor. The brine shrimp lethality test revealed that the chloroform and remaining water fractions of C. dichotomum have moderate and positive lethality with LD50 values of 169.48 and 46.26 mu g/mL, respectively. In addition, the chloroform and n-butanol fractions had low and moderate insecticidal activity with 20 and 40 % of mortality against Tribolium castaneum, respectively. Conclusion: This study demonstrates that C. dichotomum consists of bioactive constituents responsible for phytotoxicity, cytotoxicity on brine shrimps and insecticidal activity.
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    Phytotoxicity, toxicity on brine shrimp and ınsecticidal effect of chrysophthalmum gueneri aytac & anderb. growing in Turkey
    (Türkish Pharmacists Assoc, 2018) Ayaz, Fatma; Kucukboyaci, Nurgun; Bani, Baris; Sener, Bilge; Choudhary, Muhammad Iqbal
    Objectives: The aim of this study was to investigate the probable toxicity on brine shrimp, phytotoxicity, and insecticidal activity of Chrysophthalmum gueneri Aytac & Anderb. Materials and Methods: The MeOH (80%) extract obtained from the whole plant of C. gueneri was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform, and n-butanol. The MeOH (80%) extract and all fractions of C. gueneri were evaluated for their biologic activities using in vitro screening bioassays such as brine shrimp lethality test and phytotoxicity against Lemna minor, as well as insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The findings showed that the n-hexane and chloroform fractions of the plant had significant phytotoxic activities with 100% growth inhibition (GI) at 1000 mu g/mL against L. minor. Moreover, the MeOH (80%) extract (53% GI) and n-butanol fraction (46.6% GI) of the plant had moderate phytotoxic activities at 1000 mu g/mL. Otherwise, no samples had toxicity on the brine shrimps. In addition, the remaining water fraction had low insecticidal activity with 20% mortality against T. castaneum. Conclusion: Our results show that the n-hexane and chloroform fractions of C. gueneri had potential phytotoxic effects.