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    Dairy Products and Pediatric Brucellosis in Anatolia
    (Selçuk Üniversitesi, 2023 Aralık) Suman, Kamuran; Gök, Ebru; Suman, Murat; Büyük, Musa
    Introduction: The aim of this study is to assess the follow-up and treatment outcomes of pediatric brucellosis cases at our participating centers during a specific period when they were diagnosed with the disease. Methods: This research, supported by participating centers in the Central Anatolia region, was conducted over a span of approximately 2 years. We retrospectively reviewed data from patients diagnosed with brucellosis between 2018 and 2021. Patients with incomplete information in the system were excluded from the study. Results: Based on the data collected from the participating centers, our study included a total of 68 patients who met the criteria after excluding those with incomplete information. These patients were aged between 5 and 17, with an average age of 8.7±3.1 years. Our analysis of the patients’ demographics showed that they predominantly resided in rural areas where unpasteurized milk and dairy products are commonly consumed. While a few patients from higher socioeconomic backgrounds purchased organic products from local markets, the vast majority (90%) had a history of consuming unpasteurized milk and its by-products. Additionally, a significant proportion (50%) of patients from rural areas had a family history of brucellosis. The most frequently reported symptom among patients was joint pain, which was present in 83% of cases. Elevated liver enzymes were the most common laboratory finding, affecting 32% of patients, while thrombocytopenia was the least common. The preferred treatment regimen for patients was doxycycline and rifampicin. Although aminoglycoside treatment was initially favored for inpatients (80%), it was not commonly prescribed for outpatients. The data analysis revealed that only two patients experienced a relapse of the disease. While the overall treatment outcomes were successful, there was no statistically significant association between treatment preferences and disease recurrence. Conclusion: Each year, numerous children in our country are admitted to pediatric clinics with complaints of joint pain, and this leads to extensive investigations. It is crucial to consider that with a suspicious patient history and demography, brucellosis may be the underlying cause of such symptoms, along with elevated liver enzymes and cytopenia.